A comprehensive review of genetic causes of obesity
CONCLUSIONS: Genetic study technologies are in constant development; however, we are still far from having a personalized approach to genetic causes of obesity. A significant proportion of the affected individuals are associated with genetic causes; however, there are still barriers to its approach, as it continues to be underdiagnosed. Video Abstract (MP4 1041807 KB).PMID:37725322 | DOI:10.1007/s12519-023-00757-z (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 19, 2023 Category: Pediatrics Authors: Marcio Jos é Concepción-Zavaleta Juan Eduardo Quiroz-Aldave Mar ía Del Carmen Durand-Vásquez Elman Rolando Gamarra-Osorio Juan Del Carmen Valencia de la Cruz Claudia Mercedes Barrueto-Callirgos Susan Luciana Puelles-Le ón Elena de Jes ús Alvarado-Le Source Type: research
A comprehensive review of genetic causes of obesity
CONCLUSIONS: Genetic study technologies are in constant development; however, we are still far from having a personalized approach to genetic causes of obesity. A significant proportion of the affected individuals are associated with genetic causes; however, there are still barriers to its approach, as it continues to be underdiagnosed. Video Abstract (MP4 1041807 KB).PMID:37725322 | DOI:10.1007/s12519-023-00757-z (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 19, 2023 Category: Pediatrics Authors: Marcio Jos é Concepción-Zavaleta Juan Eduardo Quiroz-Aldave Mar ía Del Carmen Durand-Vásquez Elman Rolando Gamarra-Osorio Juan Del Carmen Valencia de la Cruz Claudia Mercedes Barrueto-Callirgos Susan Luciana Puelles-Le ón Elena de Jes ús Alvarado-Le Source Type: research
A comprehensive review of genetic causes of obesity
CONCLUSIONS: Genetic study technologies are in constant development; however, we are still far from having a personalized approach to genetic causes of obesity. A significant proportion of the affected individuals are associated with genetic causes; however, there are still barriers to its approach, as it continues to be underdiagnosed. Video Abstract (MP4 1041807 KB).PMID:37725322 | DOI:10.1007/s12519-023-00757-z (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 19, 2023 Category: Pediatrics Authors: Marcio Jos é Concepción-Zavaleta Juan Eduardo Quiroz-Aldave Mar ía Del Carmen Durand-Vásquez Elman Rolando Gamarra-Osorio Juan Del Carmen Valencia de la Cruz Claudia Mercedes Barrueto-Callirgos Susan Luciana Puelles-Le ón Elena de Jes ús Alvarado-Le Source Type: research
Efficacy of adenotonsillectomy on pediatric obstructive sleep apnea and related outcomes: A narrative review of current evidence
J Formos Med Assoc. 2023 Sep 15:S0929-6646(23)00348-0. doi: 10.1016/j.jfma.2023.09.004. Online ahead of print.ABSTRACTThis review summarizes the current evidence in systematic reviews, meta-analysis and randomized controlled trials regarding adenotonsillectomy outcomes in pediatric obstructive sleep apnea (OSA). Adenotonsillectomy is effective in treating OSA in children without co-morbidities, despite postoperative residual OSA remained in roughly half of these children. For children with comorbidities such as Down syndrome, Prader-Willi syndrome, sickle cell disease, or cerebral palsy, adenotonsillectomy is less effectiv...
Source: J Formos Med Assoc - September 17, 2023 Category: General Medicine Authors: Kun-Tai Kang Wei-Chung Hsu Source Type: research
Efficacy of adenotonsillectomy on pediatric obstructive sleep apnea and related outcomes: A narrative review of current evidence
J Formos Med Assoc. 2023 Sep 15:S0929-6646(23)00348-0. doi: 10.1016/j.jfma.2023.09.004. Online ahead of print.ABSTRACTThis review summarizes the current evidence in systematic reviews, meta-analysis and randomized controlled trials regarding adenotonsillectomy outcomes in pediatric obstructive sleep apnea (OSA). Adenotonsillectomy is effective in treating OSA in children without co-morbidities, despite postoperative residual OSA remained in roughly half of these children. For children with comorbidities such as Down syndrome, Prader-Willi syndrome, sickle cell disease, or cerebral palsy, adenotonsillectomy is less effectiv...
Source: J Formos Med Assoc - September 17, 2023 Category: General Medicine Authors: Kun-Tai Kang Wei-Chung Hsu Source Type: research
Efficacy of adenotonsillectomy on pediatric obstructive sleep apnea and related outcomes: A narrative review of current evidence
J Formos Med Assoc. 2023 Sep 15:S0929-6646(23)00348-0. doi: 10.1016/j.jfma.2023.09.004. Online ahead of print.ABSTRACTThis review summarizes the current evidence in systematic reviews, meta-analysis and randomized controlled trials regarding adenotonsillectomy outcomes in pediatric obstructive sleep apnea (OSA). Adenotonsillectomy is effective in treating OSA in children without co-morbidities, despite postoperative residual OSA remained in roughly half of these children. For children with comorbidities such as Down syndrome, Prader-Willi syndrome, sickle cell disease, or cerebral palsy, adenotonsillectomy is less effectiv...
Source: J Formos Med Assoc - September 17, 2023 Category: General Medicine Authors: Kun-Tai Kang Wei-Chung Hsu Source Type: research
Efficacy of adenotonsillectomy on pediatric obstructive sleep apnea and related outcomes: A narrative review of current evidence
J Formos Med Assoc. 2023 Sep 15:S0929-6646(23)00348-0. doi: 10.1016/j.jfma.2023.09.004. Online ahead of print.ABSTRACTThis review summarizes the current evidence in systematic reviews, meta-analysis and randomized controlled trials regarding adenotonsillectomy outcomes in pediatric obstructive sleep apnea (OSA). Adenotonsillectomy is effective in treating OSA in children without co-morbidities, despite postoperative residual OSA remained in roughly half of these children. For children with comorbidities such as Down syndrome, Prader-Willi syndrome, sickle cell disease, or cerebral palsy, adenotonsillectomy is less effectiv...
Source: J Formos Med Assoc - September 17, 2023 Category: General Medicine Authors: Kun-Tai Kang Wei-Chung Hsu Source Type: research
Long Non-coding RNA Prader Willi/Angelman Region RNA 6 Suppresses Glioma Development by Modulating MicroRNA-106a-5p
Biochem Genet. 2023 Aug 23. doi: 10.1007/s10528-023-10479-6. Online ahead of print.ABSTRACTAs one of the most frequent intracranial tumors, glioma showed invasive development and poor prognosis. lncRNAs have been illustrated to serve as biomarkers in various cancers. Whether the long non-coding RNA Prader Willi/Angelman region RNA 6 (PWAR6) was involved in glioma development and the underlying mechanism was investigated. PWAR6 in glioma was evaluated by polymerase chain reaction and its clinical significance was assessed with a series of statistical analyses. The biological function of PWAR6 was investigated with the cell ...
Source: Biochemical Genetics - August 23, 2023 Category: Genetics & Stem Cells Authors: Yongjun E Xianglin Zhang Heji Ma Furen Dong Source Type: research
Body Fat Distribution Contributes to Defining the Relationship between Insulin Resistance and Obesity in Human Diseases
Curr Diabetes Rev. 2023 Aug 16. doi: 10.2174/1573399820666230816111624. Online ahead of print.ABSTRACTThe risk for metabolic and cardiovascular complications of obesity is defined by body fat distribution rather than global adiposity. Unlike subcutaneous fat, visceral fat (including hepatic steatosis) reflects insulin resistance and predicts type 2 diabetes and cardiovascular disease. In humans, available evidence indicates that the ability to store triglycerides in the subcutaneous adipose tissue reflects enhanced insulin sensitivity. Prospective studies document an association between larger subcutaneous fat mass at base...
Source: Current Diabetes Reviews - August 17, 2023 Category: Endocrinology Authors: Mar ía M Adeva-Andany Alberto Dom ínguez-Montero Luc ía Adeva-Contreras Carlos Fern ández-Fernández Natalia Carneiro-Freire Manuel Gonz ález-Lucán Source Type: research
Probiotic Influences on Motor Skills: A Review
Curr Neuropharmacol. 2023 Aug 7. doi: 10.2174/1570159X21666230807150523. Online ahead of print.ABSTRACTThe effects of probiotics have mostly been shown to be favorable on measures of anxiety and stress. More recent experiments indicate single- and multi-strain probiotics in treating motor- related diseases. Initial studies in patients with Parkinson's disease and Prader-Willi syndrome are concordant with this hypothesis. In addition, probiotics improved motor coordination in normal animals and models of Parkinson's disease, multiple sclerosis, and spinal cord injury as well as gripstrength in hepatic encephalopathy. Furthe...
Source: Current Neuropharmacology - August 8, 2023 Category: Drugs & Pharmacology Authors: Robert Lalonde Catherine Strazielle Source Type: research
Probiotic Influences on Motor Skills: A Review
Curr Neuropharmacol. 2023 Aug 7. doi: 10.2174/1570159X21666230807150523. Online ahead of print.ABSTRACTThe effects of probiotics have mostly been shown to be favorable on measures of anxiety and stress. More recent experiments indicate single- and multi-strain probiotics in treating motor- related diseases. Initial studies in patients with Parkinson's disease and Prader-Willi syndrome are concordant with this hypothesis. In addition, probiotics improved motor coordination in normal animals and models of Parkinson's disease, multiple sclerosis, and spinal cord injury as well as gripstrength in hepatic encephalopathy. Furthe...
Source: Current Neuropharmacology - August 8, 2023 Category: Drugs & Pharmacology Authors: Robert Lalonde Catherine Strazielle Source Type: research
Probiotic Influences on Motor Skills: A Review
Curr Neuropharmacol. 2023 Aug 7. doi: 10.2174/1570159X21666230807150523. Online ahead of print.ABSTRACTThe effects of probiotics have mostly been shown to be favorable on measures of anxiety and stress. More recent experiments indicate single- and multi-strain probiotics in treating motor- related diseases. Initial studies in patients with Parkinson's disease and Prader-Willi syndrome are concordant with this hypothesis. In addition, probiotics improved motor coordination in normal animals and models of Parkinson's disease, multiple sclerosis, and spinal cord injury as well as gripstrength in hepatic encephalopathy. Furthe...
Source: Current Neuropharmacology - August 8, 2023 Category: Drugs & Pharmacology Authors: Robert Lalonde Catherine Strazielle Source Type: research
Ovarian cyst torsion in Prader-Willi Syndrome
Prader-Willi syndrome (PWS) is a genetic disorder involving multiple systems, with an incidence of about 1/10000 –25000. Ovarian torsion (OT) is not commonly found in children. Ovarian cyst acts as one of the p... (Source: BMC Pediatrics)
Source: BMC Pediatrics - August 8, 2023 Category: Pediatrics Authors: Ji-cun Zhao, Heng Huang, Hong-lei Gong, Qing-kai Zhao and He Wu Tags: Case report Source Type: research
Caregiver-based perception of disease burden in Schaaf-Yang syndrome
CONCLUSION: Our study demonstrates the necessity for treatments that, adapted to age and in accordance with the caregivers' prioritization, improve the patients' medical condition and thus facilitate their and their families' social participation.PMID:37533374 | DOI:10.1002/mgg3.2262 (Source: Molecular Medicine)
Source: Molecular Medicine - August 3, 2023 Category: Molecular Biology Authors: Laura D ötsch Lisa Matesevac Theresa V Strong Christian P Schaaf Source Type: research
Caregiver-based perception of disease burden in Schaaf-Yang syndrome
CONCLUSION: Our study demonstrates the necessity for treatments that, adapted to age and in accordance with the caregivers' prioritization, improve the patients' medical condition and thus facilitate their and their families' social participation.PMID:37533374 | DOI:10.1002/mgg3.2262 (Source: Molecular Medicine)
Source: Molecular Medicine - August 3, 2023 Category: Molecular Biology Authors: Laura D ötsch Lisa Matesevac Theresa V Strong Christian P Schaaf Source Type: research
