Increased IGFBP proteolysis, IGF-I bioavailability and pappalysin levels in children with Prader-Willi syndrome
CONCLUSION: The increase in PAPP-A could be involved in increased IGFBP proteolysis, promoting IGF-I bioavailability in children with PWS. Further studies are needed to establish the relationship between growth, GH resistance, and changes in the IGF axis during development and after GH treatment in these patients.PMID:38141219 | DOI:10.1210/clinem/dgad754 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 23, 2023 Category: Endocrinology Authors: Vicente Barrios Álvaro Martín-Rivada Gabriel Á Martos-Moreno Sandra Canelles Francisca Moreno-Maci án Carmen De Mingo-Alemany Maurizio Delvecchio Roberta Pajno Danilo Fintini Julie A Chowen Jes ús Argente Source Type: research
Serum Ghrelin and Glukagon-like Peptid 1 Levels in Children with Prader-Willi and Bardet-Biedl Syndromes
CONCLUSION: We found no definite role for ghrelin and GLP-1 in the pathogenesis of obesity in PWS and BBS. However, similar studies with larger series are needed.PMID:38099591 | DOI:10.4274/jcrpe.galenos.2023.2023-7-7 (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - December 15, 2023 Category: Endocrinology Authors: Doga Turkkahraman Suat Tekin Merve Gullu Guzin Aykal Source Type: research
What is the Role for Pediatric Endocrinologists in the Management of Skeletal Dysplasias?
J Clin Endocrinol Metab. 2023 Dec 11:dgad726. doi: 10.1210/clinem/dgad726. Online ahead of print.ABSTRACTChildren with skeletal dysplasias have not been consistently managed by pediatric endocrinologists despite their recognized expertise in managing genetic growth disorders. Growth-altering treatments have broadened the role of the pediatric endocrinologist to manage and sometimes become primary coordinators for genetic disorders such as Turner syndrome and Prader-Willi syndrome. We illustrate how recent advances in understanding the pathophysiology of skeletal disorders and the development of targeted treatments provide ...
Source: The Journal of Clinical Endocrinology and Metabolism - December 11, 2023 Category: Endocrinology Authors: Nadia Merchant Lynda E Polgreen Ron G Rosenfeld Source Type: research
What is the Role for Pediatric Endocrinologists in the Management of Skeletal Dysplasias?
J Clin Endocrinol Metab. 2023 Dec 11:dgad726. doi: 10.1210/clinem/dgad726. Online ahead of print.ABSTRACTChildren with skeletal dysplasias have not been consistently managed by pediatric endocrinologists despite their recognized expertise in managing genetic growth disorders. Growth-altering treatments have broadened the role of the pediatric endocrinologist to manage and sometimes become primary coordinators for genetic disorders such as Turner syndrome and Prader-Willi syndrome. We illustrate how recent advances in understanding the pathophysiology of skeletal disorders and the development of targeted treatments provide ...
Source: The Journal of Clinical Endocrinology and Metabolism - December 11, 2023 Category: Endocrinology Authors: Nadia Merchant Lynda E Polgreen Ron G Rosenfeld Source Type: research
Bariatric surgery for the adolescent with Prader-Willi syndrome: A literature review
Asian J Surg. 2023 Dec 9:S1015-9584(23)01997-8. doi: 10.1016/j.asjsur.2023.12.033. Online ahead of print.NO ABSTRACTPMID:38072692 | DOI:10.1016/j.asjsur.2023.12.033 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - December 10, 2023 Category: Surgery Authors: Huizheng Hu Lei Lei Source Type: research
Bariatric surgery for the adolescent with Prader-Willi syndrome: A literature review
Asian J Surg. 2023 Dec 9:S1015-9584(23)01997-8. doi: 10.1016/j.asjsur.2023.12.033. Online ahead of print.NO ABSTRACTPMID:38072692 | DOI:10.1016/j.asjsur.2023.12.033 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - December 10, 2023 Category: Surgery Authors: Huizheng Hu Lei Lei Source Type: research
Effect of non-pharmacological intervention on the nutritional status of patients with Prader Willi Syndrome
Obesity is highly prevalent in patients with Prader-Willi syndrome (PWS), particularly among adults. This condition, which can be morbid in many cases, is multifactorial and has a complex management. The purpose of our study was to describe the feasibility of achieving a better nutritional status, including normal weight in individuals diagnosed with PWS, through specific nutritional interventions within the framework of a transdisciplinary treatment and without resorting to pharmacological treatments or growth hormone (GH). (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 4, 2023 Category: Nutrition Authors: Romina Ceccomancini, Ayla Gerk, Jorgelina Stegmann Tags: Original article Source Type: research
