RNA deserves its own massive counterpart to the human genome project, researchers argue
This report is very much modeled on the
NASEM report
that initiated the Human Genome Project,
”
completed in 2003,
says Cheung, who wasn’t involved in the new report’s drafting. But as the report notes,
“The RNome is much more complex
”
than a genome.
For one thing, frequent modifications to RNA mean there will be no fixed, reference sequence like the one researchers produced for the human genome. For a given RNA molecule, researchers will have to document
“not only the sequence, but also the type and location of the modifica...
Source: ScienceNOW - March 21, 2024 Category: Science Source Type: news
Meet The Company Whose Hunger Suppressant Sent Shares Flying 505%
stock recently jumped more than 500% in a single day, and the biopharmaceutical company says it has now come out from "under the radar" with a potential treatment for a rare genetic disease. The company is working on a treatment for Prader Willi syndrome, a genetic disease that causes obesity,…#praderwilli #anishbhatnagar #capnia #essentialis #soleno #dccr #hyperphagia #marketsmithcom #novonordisk #nvo (Source: Reuters: Health)
Source: Reuters: Health - October 3, 2023 Category: Consumer Health News Source Type: news
EXCLUSIVE: My daughter, 11, weighs nearly 300lbs and could eat herself to death due to rare condition that leaves her ravenously hungry all the time
Sherafien McDaniel, 29, from Atlanta, Georgia, is the mother of Angel, an 11-year-old girl who suffers from Prader-Willi syndrome, a rare genetic disorder that makes her insatiably hungry. (Source: the Mail online | Health)
Source: the Mail online | Health - August 26, 2023 Category: Consumer Health News Source Type: news
Science Saturday: Improving diagnosis of rare congenital disorders
When a child falls ill, two questions quickly come front and center for parents: What ’s the problem, and what can be done to fix it? For families whose children have certain congenital disorders, the answers to those questions can be maddeningly elusive. Laboratory tests to diagnose congenital disorders of methylation, such as Beckwith-Wiedemann, Silver-Russell, Prader-Willi, a nd Angelman syndromes, often come back without a definitive result. “We can have up to 25% of our results be equivocal for these conditions, and that's… (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 26, 2022 Category: Databases & Libraries Source Type: news
What Does a Child With Prader-Willi Syndrome Look Like?
Title: What Does a Child With Prader-Willi Syndrome Look Like?Category: Diseases and ConditionsCreated: 3/2/2022 12:00:00 AMLast Editorial Review: 3/2/2022 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - March 2, 2022 Category: Pediatrics Source Type: news
Prader-Willi Syndrome: New Target for Hunger Suppression? Prader-Willi Syndrome: New Target for Hunger Suppression?
Signaling pathways in the cerebellum, rather than the hypothalamus, could provide a key for developing new therapies for the genetic disorder.Quick Take (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - November 18, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
A quality improvement project to implement choking prevention and first aid education in Prader-Willi syndrome caregivers - Obrynba KS, Anglin K, Moffett A, Steinke T, Kamboj MK.
Prader-Willi syndrome (PWS) is a complex neurodevelopmental genetic disorder characterized by hypotonia and hyperphagia. Consequently, individuals with PWS are at high risk of choking, and choking is a leading cause of morbidity and mortality. The aim of t... (Source: SafetyLit)
Source: SafetyLit - November 16, 2021 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
The impact of age and genetics on naltrexone biotransformation - Stancil SL, Nolte W, Pearce RE, Staggs VSPD, Leeder JS.
Naltrexone (NTX), an opioid antagonist primarily metabolized by Aldo-Keto Reductase 1C4 (AKR1C4), treats pediatric conditions involving compulsiveness (e.g., autism spectrum, Prader-Willi, eating disorders, non-suicidal self-injury). Pharmacokinetic variab... (Source: SafetyLit)
Source: SafetyLit - November 8, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Prader-Willi Syndrome Drug Receives a Resounding'No' from FDA Advisory Panel Prader-Willi Syndrome Drug Receives a Resounding'No' from FDA Advisory Panel
An FDA advisory panel has voted overwhelmingly against a new drug application for intranasal carbetocin, intended to treat symptoms associated with Prader-Willi Syndrome.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - November 5, 2021 Category: Drugs & Pharmacology Tags: Psychiatry News Source Type: news
Suicidality and self-harming behaviors in patients with Prader-Willi syndrome (PWS): case report and literature review - Bellman V, Abbass Z, Sohail R, Jafri S.
Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder which is often associated with significant behavioral challenges and poor intellectual functioning. Research has shown that individuals with PWS are more likely to experience mental health p... (Source: SafetyLit)
Source: SafetyLit - October 23, 2021 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
Suicidality in individuals with Prader-Willi syndrome: a review of registry survey data - Peleggi A, Bohonowych J, Strong TV, Schwartz L, Kim SJ.
INTRODUCTION: Prader-Willi syndrome (PWS) is a rare, genetic, neurodevelopmental syndrome associated with hyperphagia and early onset obesity, growth and sex hormone insufficiencies, mild-to-moderate intellectual disability, and behavioral challenges such ... (Source: SafetyLit)
Source: SafetyLit - September 12, 2021 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
Aardvark Therapeutics, Inc., Completes $29m Series B Funding Led By Sorrento Therapeutics And Including Existing Investors And The Foundation For Prader-Willi Research
Funds will support three Phase 2 clinical trials of Aardvark's lead compound to be initiated this year and advance additional products in the pipeline
SAN DIEGO, Aug. 5, 2021 -- (Healthcare Sales & Marketing Network) -- Aardvark Therapeutics, Inc., a c... Biopharmaceuticals, Venture Capital Aardvark Therapeutics (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - August 5, 2021 Category: Pharmaceuticals Source Type: news
FDA Grants Priority Review for Levo Therapeutics ’ New Drug Application for LV-101 (Intranasal Carbetocin) for the Treatment of Prader-Willi Syndrome
CHICAGO, IL, July 6, 2021 (Newswire.com) – Levo Therapeutics, Inc., a biotechnology company dedicated to using genetic insights to advance treatments for Prader-Willi syndrome (PWS) and related disorders, announced today that the U.S.... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - July 6, 2021 Category: Drugs & Pharmacology Source Type: news
Oxytocin in Young Children With Prader-Willi Syndrome Oxytocin in Young Children With Prader-Willi Syndrome
What benefits might oxytocin treatment offer in the management of children with Prader-Willi syndrome?Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 20, 2021 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
What Are Some Etiologies for Intellectual Disability?
Discussion
“Intellectual disability (ID) is a neurodevelopmental disorder that is characterized by deficits in both intellectual functioning and adaptive function whose onset is in the development period.” Global developmental delay (GDD) is used to describe children from 0-5 years old with significant delays in 2 or more developmental areas. These delays may be transient but up to 2/3 of children with GDD will have ID. Overall 1-3% of the general population has ID which makes it very common.
Most children with GDD/ID are identified because of delays in meeting milestones or general academic achievement. ID pat...
Source: PediatricEducation.org - May 3, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
