Ischemic ST depression maximal in V1-V4 (vs. V5-V6), even if less than 0.1 millivolt, is specific for Occlusion Myocardial Infarction (vs. subendocardial non-occlusive ischemia)
Conclusion: Among high-risk ACS patients, the specificity for OMI of suspected ischemic STDmaxV1-4 was 97%. STEMI criteria missed half of OMIs detected by STDmaxV1-4. These data support that any ischemic STD maximal in V1-V4 in ACS is due to OMI until proven otherwise. (Source: Dr. Smith's ECG Blog)
Source: Dr. Smith's ECG Blog - June 27, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
An ER in Kathmandu during the pandemic: a lesson on motivation
It was 2:00 a.m. I had just finished shifting a severe coronavirus disease (COVID-19) pneumonia/ARDS patient to the intensive care unit (ICU) after he was intubated in the emergency room (ER). The ER was teeming with patients awaiting admission. For new patients to get a bed, some admitted ones have to be discharged or dead.Read more …Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 25, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/bijay-phuyal" rel="tag" > Dr. Bijay Phuyal < /a > < /span > Tags: Physician Emergency Medicine Source Type: blogs
The Forever Healthy Foundation Knowledge Base on Dasatinib and Quercetin as a Senolytic Therapy
The Forever Healthy Foundation has been building a database of materials covering presently available options for the treatment of aging, all of which have little available data in comparison to more established areas of medicine. The bias in these materials is towards a very conservative viewpoint, appropriate for physicians, so you will see little to no enthusiasm for forging ahead with use, as the self-experimenters in the longevity community are presently doing. Nonetheless, this provides a convenient repositories of information, pulling together references to all of the animal and human data available for the topics u...
Source: Fight Aging! - June 24, 2021 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
In pursuit of health equity and the state of U.S. healthcare
Between 2014 and 2015, death rates increased for eight of the 10 leading causes; only death rates caused by cancer fell, and mortality rates for influenza and pneumonia stayed flat. (Source: Healthcare IT News Blog)
Source: Healthcare IT News Blog - June 15, 2021 Category: Information Technology Source Type: blogs
Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all.
Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity
https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gr...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Inflammaging and Disruption of Coagulation as Contributions to High COVID-19 Mortality in the Old
The burden of infectious disease falls most heavily upon the old. The attention given to COVID-19 has highlighted that point, though much of the media seems determined to avoid talking about the fact that near all mortality due to the condition occurs in the old and the cormorbid. It is nothing new, of course. Influenza kills tens of thousands of old people every year in the US alone, without much attention given to it. That the elderly suffer and die is old news. It is, however, old news that we should revisit in this era of revolutionary progress in medical biotechnology. The causes of aging and age-related mortality are...
Source: Fight Aging! - June 9, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Post #55 COVID-19 Vaccine for 12 to 15 Year Old Adolescents
The Pfizer vaccine will soon be offered to 12-15 year olds, raising a mild conundrum for parents.Should they skip the vaccine, given that most children have fared well when infected with COVID-19 (many already having been infected)? Or should they immunize their child(ren), even though the vaccine is relatively new and doesn ’t have a long track record?Vaccines have had their missteps, most notably the recalled RotaShield immunization in 1999. However, the recall of RotaShield and the recent temporary pause of the Johnson&Johnson COVID-19 vaccine should instill confidence in the robustness and capability o...
Source: A Pediatrician's Blog - May 8, 2021 Category: Pediatrics Source Type: blogs
Sickle cell disease in newborns and children: What families should know and do
If you’ve learned that your newborn or young child has sickle cell disease, you — and other family members and friends — may have many questions.
These days, most cases of sickle cell disease in the US are diagnosed through newborn screening. It’s important to make the diagnosis early, so that babies can be started on penicillin (or another antibiotic) to prevent infection. Getting connected early to a pediatrician for primary care — and to specialists in blood disorders who can work closely with the child as they grow, and with their families — can help prevent complications of the disease.
The basics
Hemoglob...
Source: Harvard Health Blog - May 6, 2021 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Children's Health Genes Health care disparities Parenting Source Type: blogs
Fight Aging! Newsletter, April 19th 2021
In conclusion, airway pressure treatment and adherence are independently associated with lower odds of incident AD diagnoses in older adults. Results suggest that treatment of OSA may reduce risk of subsequent dementia. (Source: Fight Aging!)
Source: Fight Aging! - April 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
COVID-19 Data Shows the Importance of Thymic Atrophy in Aging
The decline of the immune system is of great importance in aging. Vulnerability to infection, a decreased surveillance of senescent cells and cancerous cells, and growing chronic inflammation all take their toll. A sizable fraction of this problem stems from the diminished supply of new T cells of the adaptive immune system. T cells begin life as thymocytes in the bone marrow, then migrate to the thymus where they mature. Unfortunately, the thymus atrophies with age, a process known as thymic involution, in which active tissue is replaced by fat. The T cell supply falters, and as a result the existing T cell population bec...
Source: Fight Aging! - April 15, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
An 80-something with weakness, cough, and CP. Should this ECG provoke a Prehospital Cath Lab activation?
An 80-something called 911 for chest pain, generalized weakness, and cough.Here is his prehospital ECG:The medics were worried about this ECG and activated the cath labSmith: As in many prehospital ECGs with large voltage,the tracing goes off the image, making assessment of voltage impossible. Thus, it is impossible to assess the ST Segments and T-waves, which should always be assessed in proportion to the size of the QRS. I call this " proportionality " and in a non-ischemic ECG, the repolarization should always be proportional to the depolarization. Since we can ' t see the true size of t...
Source: Dr. Smith's ECG Blog - April 8, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
Paroxysmal Atrial Fibrillation with RVR, hypotension, volume depletion, good EF, AND pulmonary edema. Strange. Why? What to do?
A 30-something woman presented with a few days of feeling ill. She had a history of paroxysmal atrial fibrillation, bio-prosthetic mitral valve, and tricuspid valvuloplasty, and was on Coumadin.Records showed she is usually in sinus rhythm and has normal LV function.She presented hypotensive (systolic pressure 80), with diffuse B lines, flat IVC, good LV function, and an irregular, fast heart beat.Here is here ECG:Atrial fib with RVR and some probable ischemic ST depression in V3-V6Here is her POCUS:What do you think? There is asmall LV with good function and alarge left atrium, andmoderately large RV.Ther...
Source: Dr. Smith's ECG Blog - April 4, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, March 29th 2021
Discussion of Systemic Inflammation and its Contribution to Dementia
Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice
Reprogramming Cancer Cells into Normal Somatic Cells
Considering Longevity Medicine and the Education of Physicians
Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice
In Search of Transcriptional Signatures of Aging
A Pace of Aging Biomarker Correlates with Manifestations of Aging
Targeting Tissues with Extracellular Vesicles
Calorie Restriction Slows Aging of the Gut Microbiome in Mice
Mitochondrial DNA Heteroplasmy in the Aging Heart
Evidence...
Source: Fight Aging! - March 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fully vaccinated against COVID-19? So, what can you safely do?
Congrats on getting your COVID-19 vaccine! You qualify as fully vaccinated two weeks after your second dose of the Moderna or Pfizer/BioNTech vaccine, or two weeks after your single dose of the Johnson & Johnson vaccine, according to the US Centers for Disease Control and Prevention (CDC).
Maybe you’re wondering what you can safely do now that you’re fully vaccinated. As an infectious disease specialist, I’ve provided answers to some common questions. Please keep in mind that information about COVID-19 and vaccines is evolving, and recommendations may change as we learn more.
Can I gather with people outside my h...
Source: Harvard Health Blog - March 25, 2021 Category: Consumer Health News Authors: Amy C. Sherman, MD Tags: Coronavirus and COVID-19 Health Parenting Relationships Vaccines Source Type: blogs
What the Exponential Rise in Mortality with Age Tells Us About the Nature of Aging
When charting rising mortality against increasing chronological age, the result is a smooth exponential curve - the Gompertz-Makeham law of mortality. We might well ask how the exceptionally complicated process of degenerative aging, consisting of many distinct mechanisms butting heads and breaking things in a stochastic manner, can produce this outcome. This is one of the questions posed by epidemiologists in today's open access paper. It is a good example that shows how a scientist can hypothesize about the operation of mechanisms given only data on the outcomes of those mechanisms.
For context, the authors of the...
Source: Fight Aging! - March 22, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
