Deuterium substitution improves therapeutic and metabolic profiles of medicines
(The Yates Network) Substituting deuterium for certain hydrogen atoms in molecules provides a promising approach to discovery and development of innovative drug products, building on the known pharmacology of existing compounds. Selective deuterium substitution as a means of ameliorating unwanted clinically relevant pharmacokinetic drug interactions caused by the widely-used antidepressant agent paroxetine (marketed as Paxil®) was demonstrated by researchers at Concert Pharmaceuticals and published in the July 2015 print edition of the Journal of Pharmacology and Experimental Therapeutics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 1, 2015 Category: Global & Universal Source Type: news
Antidepressant use in menopause linked to broken bones
Conclusion This study found women aged 40-64 years without mental health illness who started taking SSRI medications had significantly higher fracture risk up to five years after starting, compared with women taking other drugs prescribed for stomach ulcers or irritation (H2A or PPIs). Risk difference was statistically significant only after the second year, suggesting SSRIs may need several months to produce clinically meaningful effects on bone mineral density. Importantly, and acknowledged by the study authors, this study can't prove cause and effect. There may be other confounding factors mediating the link between the...
Source: NHS News Feed - June 26, 2015 Category: Consumer Health News Tags: Medication Older people Source Type: news
Antidepressants During Pregnancy Pose Low Risk To Unborn Baby, Study Finds
http://media.boston.cbslocal.com/CBSBOS_0206201517230400000AA.mp4 BOSTON (CBS) — In 2006, the FDA warned the public that the use of common antidepressants, like Prozac and Paxil, late in pregnancy could put a baby at risk for respiratory failure. But a new study from a local hospital shows that risk may not really exist. The FDA advisory pointed to a single study showing a six-fold increased risk of a condition called persistent pulmonary hypertension of the newborn in women taking antidepressants. But a new large-scale study says the risk is negligible. Researchers at Brigham and Women’s Hospital ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - June 2, 2015 Category: Consumer Health News Authors: larasalahi Tags: Health Local News Syndicated Local Antidepressants Brigham And Womens CBS Boston Pregnancy Pregnant WBZ Source Type: news
My Journey with Anxiety
There is a problem in thinking that you are supposed to be advancing in your practice all the time. You don’t have to constantly be on the road. If you have a flat tire, that is also part of the journey. – Chogyam Trungpa My healing process after my breakdown has seemed pretty smooth, even if it has taken some time, the need to discover and use several new “tools” and, most of all, quite a huge effort. In these months I’ve been reading and listening to hundreds of opinions about how non-linear the healing process usually is, about how the line that describes the way we feel day after day is more of a tang...
Source: Psych Central - May 21, 2015 Category: Psychiatry Authors: Alexis Flye Tags: Anxiety Disorders General Medications Personal Stories Psychotherapy anxious thoughts Chögyam Trungpa recovery Source Type: news
A fatal case of poisoning with ethanol and psychotropic drugs with putrefactive changes - Kinoshita H, Tanaka N, Jamal M, Kumihashi M, Takakura A, Tobiume T, Tsutsui K, Ameno K.
We present a fatal case involving poisoning with paroxetine, flunitrazepam, and ethanol, with putrefactive changes. Quantitative toxicological analysis showed that the concentrations of paroxetine and 7-aminoflunitrazepam, a metabolite of flunitrazepam, in... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - May 19, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
First Times and Anxiety
How do you understand when anxiety is finally over? I’ve asked myself this question many times. Let me be frank: I have no answer to that. Nevertheless, a few months ago I casually stumbled upon the following quote and I believe I couldn’t have found a better way to describe my feelings: Once the storm is over you won’t remember how you made it through, how you managed to survive. You won’t even be sure, in fact, whether the storm is really over. But one thing is certain. When you come out of the storm you won’t be the same person who walked in. That’s what this storm’s all about. — Haruki Murakami, Kaf...
Source: Psych Central - May 12, 2015 Category: Psychiatry Authors: Alexis Flye Tags: Anti-anxiety Antidepressants Disorders General Medications Personal Stories Psychotherapy Agoraphobia fainting first times Insomnia Psychopharmaceuticals Social Anxiety Source Type: news
The Future of Trauma
Post-Traumatic Stress Disorder (PTSD) has been a mental health condition, classified in the Diagnostic Statistical Manual (DSM) of the American Psychiatric Association (APA), since 1980. The Diagnostic Statistical Manual (DSM-III) in 1980 classified PTSD as an anxiety disorder, DSM IV (1994) and DSM-IV Textual Revision (TR) also reaffirmed PTSD as an anxiety disorder. DSM-5 (2013) reclassified PTSD as a Trauma and Stress-Related Disorder. PTSD in terms of its longevity, 35 years as a recognized diagnosis, can be seen as a young adult. However, the phenomena of intrusive thoughts, nightmares, startle response, psychic nu...
Source: Healthy Living - The Huffington Post - April 3, 2015 Category: Consumer Health News Source Type: news
Medication and Anxiety
Medication can be an effective approach for managing various types of anxiety such as panic, hyperarousal, and constant worry. However, contrary to popular belief and subtle messages from pharmaceutical companies, medication is far from a cure. In fact, when it comes to “cures” for most psychiatric conditions, the data tends to support psychotherapy. For example, post-traumatic stress disorder (PTSD) responds very well to psychotherapy, whereas the positive effects of medication are somewhat limited. The same is true for panic disorder. Although certain types of medication are very good at relieving panic sympt...
Source: Psych Central - March 11, 2015 Category: Psychiatry Authors: Bret Moore, PsyD Tags: Anti-anxiety Antidepressants Benzodiazepines Disorders General Medications Panic Disorder anti-anxiety medications Drug Dependency Fear Hyperarousal Sedatives Selective Serotonin Reuptake Inhibitor snri Ssri Substance Abuse Source Type: news
Prolonged exposure, paroxetine and the combination in the treatment of PTSD following a motor vehicle accident. A randomized clinical trial - The "TRAKT" study - Popiel A, Zawadzki B, Pragłowska E, Teichman Y.
BACKGROUND AND OBJECTIVE: Little is known about direct comparisons of the efficacy of trauma-focused psychotherapies and SSRIs. This is the first randomized clinical trial comparing the efficacy of prolonged exposure (PE), paroxetine (Ph) and their combina... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - March 4, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
Title: paroxetine (Brisdelle)Category: MedicationsCreated: 2/24/2015 12:00:00 AMLast Editorial Review: 2/24/2015 12:00:00 AM (Source: MedicineNet Menopause General)
Source: MedicineNet Menopause General - February 24, 2015 Category: Primary Care Source Type: news
Exposure to antidepressants during gestation influences anxiety behavior later in life
Courtesy of Anne Andrews Anne Andrews About 15 percent of U.S. women suffer from anxiety disorders and depression during their pregnancies, and many are prescribed antidepressants. However, little is known about how their children might be affected by exposure to these medications in the womb. It’s a vital question because 5 percent of all babies born in the U.S. — more than 200,000 a year — are exposed to antidepressants via transmission from their mothers during gestation. Now, a UCLA team studying early developmental exposure to two different antidepressants, Prozac and Lexapro, has found that although the two dr...
Source: UCLA Newsroom: Health Sciences - January 13, 2015 Category: Universities & Medical Training Source Type: news
Anxiety Can Lead to Depression, and Depression Repays the Favor
Anxiety and depression often go hand in hand. Many people who have one will experience the other at some point. In fact, nearly one-half of those diagnosed with depression are also diagnosed with an anxiety disorder. When you miss work, sleep too much or feel sad most of the day nearly every day, you are bound to miss opportunities at work and in life. Your love life may suffer, you may run into financial problems, and while experiencing a deep and overwhelming depression, you may have trouble keeping up with the things that used to be important to you. Then, when the depression begins to lift, you may realize that you hav...
Source: Healthy Living - The Huffington Post - November 21, 2014 Category: Consumer Health News Source Type: news
OPINION: Tackling the Proliferation of Patents to Avoid Limitations to Competition
In this column, Carlos Correa, the South Centre's special adviser on trade and intellectual property issues, argues that the global increase in number of patents does not indicate the strength of innovation but a weakening in the standards of what can be considered patentable. He calls for an intrinsically balanced system of protection of innovation that remains neutral in its effects on competition.By Carlos M. CorreaGENEVA, Sep 29 2014 (IPS)The steady increase in patent applications and grants that is taking place in developed and some developing countries (notably in China) is sometimes hailed as evidence of the strengt...
Source: IPS Inter Press Service - Health - September 29, 2014 Category: Global & Universal Authors: carlos-m-correa Tags: Economy & Trade Global Headlines Health Natural Resources TerraViva United Nations Agreement on Trade-related Aspects of Intellectual Property Rights (TRIPS) Argentina China Chinese Patent Office clean energy competition developed Source Type: news
Depression in cancer patients 'neglected'
But new integrated treatment programme can have 'striking' benefitsRelated items from OnMedicaMortality higher if using paroxetine and tamoxifenUK falls behind other nations in preventing avoidable deathAlso in the pressNew treatment cuts depression in cancer patientsCancer survivors more prone to stress than others (Source: OnMedica Latest News)
Source: OnMedica Latest News - August 28, 2014 Category: UK Health Source Type: news