Deuterium substitution improves therapeutic and metabolic profiles of medicines

(The Yates Network) Substituting deuterium for certain hydrogen atoms in molecules provides a promising approach to discovery and development of innovative drug products, building on the known pharmacology of existing compounds. Selective deuterium substitution as a means of ameliorating unwanted clinically relevant pharmacokinetic drug interactions caused by the widely-used antidepressant agent paroxetine (marketed as Paxil®) was demonstrated by researchers at Concert Pharmaceuticals and published in the July 2015 print edition of the Journal of Pharmacology and Experimental Therapeutics.

Source: EurekAlert! - Medicine and Health - July 1, 2015 Category: Global & Universal Source Type: news