Chest pain and anterior ST depression. What ’s the cause(s)?
Written by Jesse McLaren, with edits from Smith and GrauerA 60 year old with no past medical history presented with two hours of chest pain radiating to the left arm, with normal vitals. What do you think? I sent this to Dr. Meyers without any other information, and he responded, “do you have a prior to make sure that it is all just because of the delta wave? Would be careful to make sure it’s not inferoposterior OMI superimposed on baseline WPW.” In other words, when there are ST/T wave changes thefirst question is whether there ’s abnormal depolarization, because this will be followed by abnormal ...
Source: Dr. Smith's ECG Blog - October 13, 2022 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Framework for Managing Complex Change
Change is hard regardless of change. However, complex changes are even harder because it generally means that multiple parties have to change. Each person has their own framework for why they do or don’t want to change. Aligning all those parties is complex. The bad news for healthcare is that almost every change is complex. You have to convince multiple people, navigate challenging regulations, and understand a wild set of often perverse incentives.
When new people come into healthcare, they often come really excited to make an impact for good. However, they bump into the challenge of managing complex ch...
Source: EMR and HIPAA - October 3, 2022 Category: Information Technology Authors: John Lynn Tags: Ambulatory C-Suite Leadership Healthcare IT Hospital - Health System LTPAC Healthcare Change Healthcare Complexity Healthcare Leadership Jay Parkinson Source Type: blogs
The impact of a lack of diagnosis reaches far and wide
Getting a medical diagnosis can actually be a huge relief. I know it may seem counter-intuitive. Saying “I have cancer,” “I have Parkinson’s,” or “I have depression” definitely doesn’t belong in the same realm as being relieved. Or maybe it does. When was the last time you saw a GoFundMe for “gradually progressive neurologic symptoms
Read more…
The impact of a lack of diagnosis reaches far and wide originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 3, 2022 Category: General Medicine Authors: Susan J. Baumgaertel, MD Tags: Conditions OB/GYN Source Type: blogs
" And then a Plank in Reason, broke, "
“I am dead.” In terms of possible delusions in living human beings,Le d élire des négations—the nihilistic delusion that one is dead —evokes the most harrowing existence imaginable. The French neurologistJules Cotard first described the syndrome that bears his name (1882,English translation):I hazard the name ofdelirium of negations to designate the state of the patients ... in whom the negative disposition is carried to the highest degree. [They are] asked their name – they have no name; their age – they are ageless; where were they born – they were not born; ... if they have a headache, s...
Source: The Neurocritic - September 30, 2022 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
Fight Aging! Newsletter, September 26th 2022
This study examined the dose-response association between daily step count and intensity and incidence of all-cause dementia among adults in the UK. This was a UK Biobank prospective population-based cohort study (February 2013 to December 2015) with 6.9 years of follow-up (data analysis conducted May 2022). A total of 78,430 of 103,684 eligible adults aged 40 to 79 years with valid wrist accelerometer data were included. Registry-based dementia was ascertained through October 2021.
We found no minimal threshold for the beneficial association of step counts with incident dementia. Our findings suggest that approxima...
Source: Fight Aging! - September 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Age-Related Inflammation Makes ɑ-synuclein Aggregation Worse
In this study we evaluated the role of aging in neurodegeneration in the ɑ-syn pff model. We found that inoculation of ɑ-syn pff in aged mice resulted in greater spreading and deficits compared to young mice, with ɑ-syn pff-inducing gene networks in young mice that overlapped with genes differentially expressed in aged mice. We propose that changes in inflammatory gene expression underly the increased susceptibility of aged mice to enhanced ɑ-syn induced pathology and might represent a new avenue for therapeutics.
Link: https://doi.org/10.1186/s13024-022-00564-6 (Source: Fight Aging!)
Source: Fight Aging! - September 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Irisin Mediates the Effects of Physical Exercise on Parkinson's Disease Progression
Exercise is known to slow the progression of Parkinson's disease, or at least attenuate the symptoms. What is the underlying mechanism? Researchers here suggest that the myokine signal protein irisin accounts for much of this, by promoting greater removal of problematic α-synuclein aggregates. Parkinson's disease is associated with α-synuclein misfolding and consequent aggregation, these toxic versions of a normally helpful protein spreading through the central nervous system over time to cause cell death and dysfunction in vulnerable populations of neurons. Clearing misfolded α-synuclein seems a viable strategy, given ...
Source: Fight Aging! - September 20, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
I Suspect It Says Something That A Three Million Dollar Grant In Digital Health Makes News!
This release appeared last week.ANDHealth - Special Announcement: 7 September 2022ANDHealth, Australia ’s leading digital health commercialisation organisation, in partnership with the Victorian Government, today announced it has received $2.4M from the Australian Medtech Manufacturing Centre and Biotechnology Fund to create the Victorian Connected Health Innovation& Commercialisation Centre (CHICC).The CHICC has been established to drive the creation and commercialisation of digital and digitally enabled medical technology companies and raise Victoria ’s profile as a leading centre for Australia’s fast grow...
Source: Australian Health Information Technology - September 14, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
AI Device Monitors Breathing to Diagnose Parkinson ’s
Researchers at MIT have developed an AI system that can diagnose Parkinson’s disease and track its progression, simply by monitoring someone’s breathing patterns as they sleep. The device looks like an internet router and can be mounted on the wall in a bedroom. It emits radio waves and then a neural network analyzes the reflected waves to assess breathing patterns. Crucially, the technology may be able to assist in diagnosing Parkinson’s disease much earlier than many conventional techniques and it is highly convenient and non-invasive compared with traditional diagnostics. It may also be particularly beneficial in ...
Source: Medgadget - September 6, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Telemedicine mit parkinsons Source Type: blogs
Fight Aging! Newsletter, September 5th 2022
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The most interesting part of the data is perhaps the decline in microbial diversity, when considered against the gains elsewhere. Microbial dive...
Source: Fight Aging! - September 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Overseas Health IT Links –3rd September, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment-----https://healthitanalytics.com/news/machine-learning-tools-predict-post-op-complications-surgery-durationMachine-Learning Tools Predict Post-Op Complications, Surgery DurationResearchers from Washington University in St. Louis have developed machine-learning tools that can predict post-operative complications and surgery duration using perioperative data.ByShania K...
Source: Australian Health Information Technology - September 3, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Elongated Isoform of Aquaporin-4 Can Enhance Clearance of Amyloid- β from the Brain
Researchers here report on an interesting discovery relating to the way in which aquaporin-4 functions in clearance of molecular waste from the brain. An uncommon isoform of aquaporin-4 has a role in clearing excess amyloid-β, and possibly many other forms of molecular waste. Given that a failure of clearance of molecular waste from the brain is apparently involved in many neurodegenerative conditions, approaches that enhance clearance are promising. Increased amounts of this more effective isoform can be achieved via a variety of strategies in mice, and in mice engineered to generate excess amyloid-β, this results in a ...
Source: Fight Aging! - September 2, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Senolytics, a Promising New Field of Medicine in the Treatment of Aging
It is becoming harder for the world at large to ignore the field of senolytics, the large number of research groups and companies working towards therapies that clear a fraction of senescent cells from aged tissues. Senescent cells accumulate in later life, likely because the immune system becomes less able to remove them promptly. Lingering senescent cells actively disrupt normal tissue function and provoke chronic inflammation, thus contributing to age-related degeneration. Scores of mouse studies conducted over the last decade demonstrate that senolytic treatments produce rapid, reliable reversal of many age-related con...
Source: Fight Aging! - September 1, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 29th 2022
This study demonstrates that adoptive astrocytic Mt transfer enhances neuronal Mn-SOD-mediated anti-oxidative defense and neuroplasticity in the brain, which potentiate functional recovery following ICH.
First Generation Stem Cell Therapies Remain Comparatively Poorly Understood
https://www.fightaging.org/archives/2022/08/first-generation-stem-cell-therapies-remain-comparatively-poorly-understood/
We are something like thirty years into the increasingly widespread use of first generation stem cell therapies. Cells are derived from a variety of sources, processed, and transplanted into patients. Near all...
Source: Fight Aging! - August 28, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Dysfunction in the Blood-Brain Barrier May Harm Neural Function Even Prior to Leakage
Researchers here present evidence for the proposition that the blood-brain barrier doesn't just become leaky with age, but also causes disruption of neural function in other ways yet to be fully explored. The primary function of the blood-brain barrier is to regulate passage of molecules and cells into the central nervous system, and when that breaks down the consequence is chronic inflammation in brain tissue, contributing to the onset and progression of neurodegenerative conditions. It seems that the harms may start somewhat before the blood-brain barrier is sufficiently compromised to leak, however.
The breakdo...
Source: Fight Aging! - August 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
