A personal journey through hospital-acquired psychosis [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join us for a touching and insightful episode with Natasha Khalid, a geriatrics fellow, as she shares her personal experience of dealing with ICU psychosis in a loved one. Natasha takes us on a journey through her grandmother’s story of battling Parkinson’s and intestinal
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A personal journey through hospital-acquired psychosis [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 12, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Critical Care Hospital-Based Medicine Source Type: blogs
Fight Aging! Newsletter, March 13th 2023
In this study, we report the extensive and progressive accumulation of misfolded proteins during natural aging/senescence in different models, in the absence of disease. We coined the term age-ggregates to refer to this subset of proteins. Our findings demonstrate that age-ggregates exhibit the main characteristics of misfolded protein aggregates implicated in PMDs, including insolubility in detergents, protease-resistance, and staining with dyes specific for misfolded aggregates. Misfolded protein aggregates with these characteristics are thought to be implicated in some of today most prevalent diseases, including Alzheim...
Source: Fight Aging! - March 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Misfolded Proteins Accumulate with Age in Nematodes and Mice
In this study, we report the extensive and progressive accumulation of misfolded proteins during natural aging/senescence in different models, in the absence of disease. We coined the term age-ggregates to refer to this subset of proteins. Our findings demonstrate that age-ggregates exhibit the main characteristics of misfolded protein aggregates implicated in PMDs, including insolubility in detergents, protease-resistance, and staining with dyes specific for misfolded aggregates. Misfolded protein aggregates with these characteristics are thought to be implicated in some of today most prevalent diseases, including Alzheim...
Source: Fight Aging! - March 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Towards Transplantation of Stem Cell Derived Neurons for Parkinson's Disease
The more obvious manifestations of Parkinson's disease stem from the the loss of a small population of dopamine-generating neurons. These cells are more sensitive to the underlying pathology of α-synuclein protein aggregation that drives the condition. Researchers have been working towards cell therapies that deliver new neurons for a long time now. A variety of clinical trials are underway, using a variety of cell sources; here, one of those programs has advanced to the stage of a first treated patient. None of these programs have yet emerged into widespread clinical practice. Is replacing cells the best way forward in t...
Source: Fight Aging! - March 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Microglial Autophagy in Parkinson's Disease
Autophagy is the name given to a collection of maintenance processes responsible for clearing waste and damaged proteins and structures from the cell. Autophagy is implicated in aging. It is thought to become dysfunctional and less efficient in cells in aging tissues. Further, evidence suggests that improved autophagy is an important mechanisms in the slowing of aging produced by calorie restriction and a range of other interventions tested in laboratory species. Here, researchers discuss the relationship between aging and autophagy specifically in the context of Parkinson's disease and the role of inflammatory microglia i...
Source: Fight Aging! - February 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing Exercise as a Means to Slow Neurodegeneration
Researchers here review the evidence for exercise to slow the onset and progression of neurodegenerative conditions. A mountain of evidence demonstrates exercise (and the practice of calorie restriction) to improve long term health and at least modestly slow age-related degeneration. For the cost, meaning essentially free, it is a good deal. The future will bring medical technologies that can greatly improve upon the benefits of exercise by targeting the underlying causes of aging, but for now it remains one of the best options on the table.
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disea...
Source: Fight Aging! - February 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Tivity Health Acquires Industry Leading Digital Health and Wellness Platform Burnalong
Acquisition will accelerate digital transformation and enhance efforts to support diverse populations and address chronic disease
Tivity Health®, a leading provider of healthy life-changing solutions, today announced that it has acquired Burnalong®, a digital health, wellness and fitness platform. The acquisition will accelerate Tivity Health’s efforts to provide consumers with a robust digital platform and extensive health and wellness content, in addition to in-person opportunities through its network of fitness locations. Burnalong will also further enable Tivity Health to support diverse and at-risk populations...
Source: EMR and HIPAA - February 14, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Burnalong Chronic Disease Management Chronic Diseases Chronic Illness Daniel Freedman Digital Health Fitness and Wellness Health IT Acquisitions Healthcare M&A Mike Kott Richard Ashworth SilverSnea Source Type: blogs
Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed.
The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Microglial Autophagy in the Context of Neurodegenerative Conditions
Changes in the function and activity of microglia in the brain, innate immune cells analogous to the macrophages present in the rest of the body, are known to be involved in the onset and progression of neurodegenerative conditions. Aging and neurodegeneration are associated with a growing presence of both senescent microglia and activated microglia Both of these states producing inflammatory signaling, contributing to the chronic, unresolved inflammation of brain tissue that is also characteristic of later life.
Autophagy is the name given to a collection of cellular maintenance processes responsible for recycling ...
Source: Fight Aging! - February 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Viral Infection in Middle Age Correlates with Later Dementia Risk
A range of evidence suggests that persistent viral infection contributes to the risk of suffering neurodegenerative conditions such as Alzheimer's disease. This may be due to mechanisms relating to amyloid-β accumulation, in its role as an anti-microbial peptide, a part of the innate immune system. It may have more to do with lasting chronic inflammation subsequent to infection. Researchers here note another addition to the epidemiological data on this topic, in this case linking severe infections requiring hospitalization with later dementia risk. The effect sizes here are large and last for a long time following infecti...
Source: Fight Aging! - February 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Parkinson ’ s Drug Proves Effective in Relieving Depression Symptoms (M)
Unlocking the secret of inflammation in the brain may hold the key to treating depression in a surprising new way. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 7, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Depression subscribers-only Source Type: blogs
Six Minutes To Better Memory: Exercise Boosts BDNF And Resists Brain Aging
Just six minutes of exercise improves memory while reducing the risk of Parkinson's and Alzheimer's disease. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 7, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Dementia Source Type: blogs
Fight Aging! Newsletter, February 6th 2023
In conclusion, our study reveals that aging enhances atherosclerosis via increased inflammation of visceral fat. Our study suggests that future therapies targeting the visceral fat may reduce atherosclerosis diseaseburden in the expanding older population.
Is the Gut a Significant Source of Amyloid-β in Alzheimer's Disease?
https://www.fightaging.org/archives/2023/02/is-the-gut-a-significant-source-of-amyloid-%ce%b2-in-alzheimers-disease/
The early stages of Alzheimer's disease are characterized by rising levels of amyloid-β in the brain and the formation of misfolded amyloid aggregates. It is present...
Source: Fight Aging! - February 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is the Gut a Significant Source of Amyloid- β in Alzheimer's Disease?
The early stages of Alzheimer's disease are characterized by rising levels of amyloid-β in the brain and the formation of misfolded amyloid aggregates. It is presently thought that this is a necessary precursor for the more harmful later stages of the condition, in which chronic inflammation and tau aggregation cause widespread cell death in the brain. It has been noted that amyloid-β exists outside the brain, and there is evidence for levels of amyloid-β in the vasculature to be in dynamic equilibrium with amyloid-β in the brain. Clearing amyloid-β from the bloodstream has shown some promise as an approach to reduce ...
Source: Fight Aging! - February 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
