Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models
In this study, we tested the anticancer potential of selected cannabinoids CBD (cannabidiol) and its quinone derivative CBD-HQ (cannabidiol hydroquinone), CBG (cannabigerol) and its acid derivative CBG-A (cannabigerolic acid), as well as a combination of CBD+CBG on the colon cancer cell line SW-620. The MTT assay was used to determine the cannabinoids' ability to induce colon cancer cell death. All cannabinoids were cytotoxic at the lowest concentration (3 μg/mL). The half maximal inhibitory concentration (IC50) ranged from 3.90 to 8.24 μg/mL, depending on the substance. Cytotoxicity was confirmed in a 3D spheroidal cell...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Dorota B ęben Oliwia Siwiela Anna Szyjka Micha ł Graczyk Daniel Rzepka Ewa Barg Helena Moreira Source Type: research
Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry
This study aims to assess changes in validated patient-reported outcome measures (PROMs) and CBMP clinical safety in patients with osteoarthritis. A prospective case series from the UK Medical Cannabis Registry was analyzed. Primary outcomes were changes in the Brief Pain Inventory (BPI), McGill Pain Questionnaire (MPQ2), EQ-5D-5L, Generalized Anxiety Disorder-7 (GAD-7) questionnaire, and Single-Item Sleep Quality Scale (SQS) at 1-, 3-, 6-, and 12-month follow-ups from baseline. Common Terminology Criteria for Adverse Events v.4.0 was used for adverse event (AE) analysis. Statistical significance was defined as p < 0.05...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 26, 2024 Category: Palliative Care Authors: Ann Francis Simon Erridge Carl Holvey Ross Coomber Wendy Holden James Rucker Michael Platt Mikael Sodergren Source Type: research
The Effect of Guided Imagery and Progressive Muscle Relaxation on Sedation in Patients Undergoing Noninvasive Mechanical Ventilation
This study included 80 patients with a mean age (± SD) of 59.59 ± 9.27 years. The Quade nonparametric ANCOVA revealed the significant impact of intervention on the post values of Total score (p-value < 0.001), Tolerance (p-value < 0.001), Calmness (p-value < 0.001), Ventilator synchrony (p-value < 0.001), face relaxation (p-value < 0.001), Consciousness (p-value = 0.009) and Awakeness (p-value = 0.020). The study findings demonstrated the effectiveness of relaxation program in promoting sedation in patients undergoing NIV. Accordingly, intensive care unit (ICU) nurses at our institution are encouraged to u...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 26, 2024 Category: Palliative Care Authors: Atefe Salimi Akinabadi Sorour Khari Mehdi Azizmohammad Looha Mitra Zandi Source Type: research
Gastro-Intestinal Symptoms in Palliative Care Patients
Curr Oncol. 2024 Apr 21;31(4):2341-2352. doi: 10.3390/curroncol31040174.ABSTRACTThis review of the palliation of various gastro-intestinal (GI) symptoms encountered in cancer patients is by no means exhaustive. Frequent symptoms such as constipation, nausea and vomiting, bowel obstructions, ascites and bleeds will be discussed, focusing on their assessment and most importantly, how to control the associated symptoms. All of these symptoms and GI complications can significantly impact patients' quality of life (QOL) and should be treated as quickly and aggressively as possible.PMID:38668077 | PMC:PMC11049445 | DOI:10.3390/c...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Golda Elisa Tradounsky Source Type: research
True Donor Cell Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: Diagnostic and Therapeutic Considerations-Brief Report
Curr Oncol. 2024 Apr 5;31(4):2067-2075. doi: 10.3390/curroncol31040153.ABSTRACTDonor cell leukemia (DCL) is a rare complication after allogeneic hematopoietic stem cell transplantation (HSCT) accounting for 0.1% of relapses and presenting as secondary leukemia of donor origin. Distinct in phenotype and cytogenetics from the original leukemia, DCL's clinical challenge lies in its late onset. Its origin is affected by donor cell anomalies, transplant environment, and additional mutations. A 43-year-old woman, treated for early stage triple-negative breast cancer, developed mixed-phenotype acute leukemia (MPAL), 12 years late...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mich èle Hoffmann Yara Banz J örg Halter Jacqueline Schoumans Jo ëlle Tchinda Ulrike Bacher Thomas Pabst Source Type: research
Deterioration of Performance Status during Palliative Radiotherapy Suggests a Significant Short Survival Duration: Indicating the Necessities for Considering Radiotherapy Discontinuation
This study aimed to investigate the survival duration of patients whose performance status (PS) deteriorated during palliative radiotherapy and inform decisions regarding early treatment discontinuation. We retrospectively analyzed data from patients referred from our institute's palliative care department who underwent ≥10 fractions of palliative radiotherapy between March 2017 and December 2021. PS was assessed using the Eastern Cooperative Oncology Group (ECOG) scale. Survival duration was calculated from the final day of palliative radiotherapy to death using the Kaplan-Meier method. A total of 35 patients underwent ...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Hitoshi Maemoto Kazuaki Kushi Isoko Owan Takuro Ariga Joichi Heianna Akihiro Nishie Source Type: research
Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models
In this study, we tested the anticancer potential of selected cannabinoids CBD (cannabidiol) and its quinone derivative CBD-HQ (cannabidiol hydroquinone), CBG (cannabigerol) and its acid derivative CBG-A (cannabigerolic acid), as well as a combination of CBD+CBG on the colon cancer cell line SW-620. The MTT assay was used to determine the cannabinoids' ability to induce colon cancer cell death. All cannabinoids were cytotoxic at the lowest concentration (3 μg/mL). The half maximal inhibitory concentration (IC50) ranged from 3.90 to 8.24 μg/mL, depending on the substance. Cytotoxicity was confirmed in a 3D spheroidal cell...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Dorota B ęben Oliwia Siwiela Anna Szyjka Micha ł Graczyk Daniel Rzepka Ewa Barg Helena Moreira Source Type: research
Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry
This study aims to assess changes in validated patient-reported outcome measures (PROMs) and CBMP clinical safety in patients with osteoarthritis. A prospective case series from the UK Medical Cannabis Registry was analyzed. Primary outcomes were changes in the Brief Pain Inventory (BPI), McGill Pain Questionnaire (MPQ2), EQ-5D-5L, Generalized Anxiety Disorder-7 (GAD-7) questionnaire, and Single-Item Sleep Quality Scale (SQS) at 1-, 3-, 6-, and 12-month follow-ups from baseline. Common Terminology Criteria for Adverse Events v.4.0 was used for adverse event (AE) analysis. Statistical significance was defined as p < 0.05...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 26, 2024 Category: Palliative Care Authors: Ann Francis Simon Erridge Carl Holvey Ross Coomber Wendy Holden James Rucker Michael Platt Mikael Sodergren Source Type: research
The Effect of Guided Imagery and Progressive Muscle Relaxation on Sedation in Patients Undergoing Noninvasive Mechanical Ventilation
This study included 80 patients with a mean age (± SD) of 59.59 ± 9.27 years. The Quade nonparametric ANCOVA revealed the significant impact of intervention on the post values of Total score (p-value < 0.001), Tolerance (p-value < 0.001), Calmness (p-value < 0.001), Ventilator synchrony (p-value < 0.001), face relaxation (p-value < 0.001), Consciousness (p-value = 0.009) and Awakeness (p-value = 0.020). The study findings demonstrated the effectiveness of relaxation program in promoting sedation in patients undergoing NIV. Accordingly, intensive care unit (ICU) nurses at our institution are encouraged to u...
Source: Journal of Pain and Palliative Care Pharmacotherapy - April 26, 2024 Category: Palliative Care Authors: Atefe Salimi Akinabadi Sorour Khari Mehdi Azizmohammad Looha Mitra Zandi Source Type: research
Gastro-Intestinal Symptoms in Palliative Care Patients
Curr Oncol. 2024 Apr 21;31(4):2341-2352. doi: 10.3390/curroncol31040174.ABSTRACTThis review of the palliation of various gastro-intestinal (GI) symptoms encountered in cancer patients is by no means exhaustive. Frequent symptoms such as constipation, nausea and vomiting, bowel obstructions, ascites and bleeds will be discussed, focusing on their assessment and most importantly, how to control the associated symptoms. All of these symptoms and GI complications can significantly impact patients' quality of life (QOL) and should be treated as quickly and aggressively as possible.PMID:38668077 | PMC:PMC11049445 | DOI:10.3390/c...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Golda Elisa Tradounsky Source Type: research
True Donor Cell Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: Diagnostic and Therapeutic Considerations-Brief Report
Curr Oncol. 2024 Apr 5;31(4):2067-2075. doi: 10.3390/curroncol31040153.ABSTRACTDonor cell leukemia (DCL) is a rare complication after allogeneic hematopoietic stem cell transplantation (HSCT) accounting for 0.1% of relapses and presenting as secondary leukemia of donor origin. Distinct in phenotype and cytogenetics from the original leukemia, DCL's clinical challenge lies in its late onset. Its origin is affected by donor cell anomalies, transplant environment, and additional mutations. A 43-year-old woman, treated for early stage triple-negative breast cancer, developed mixed-phenotype acute leukemia (MPAL), 12 years late...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mich èle Hoffmann Yara Banz J örg Halter Jacqueline Schoumans Jo ëlle Tchinda Ulrike Bacher Thomas Pabst Source Type: research
Deterioration of Performance Status during Palliative Radiotherapy Suggests a Significant Short Survival Duration: Indicating the Necessities for Considering Radiotherapy Discontinuation
This study aimed to investigate the survival duration of patients whose performance status (PS) deteriorated during palliative radiotherapy and inform decisions regarding early treatment discontinuation. We retrospectively analyzed data from patients referred from our institute's palliative care department who underwent ≥10 fractions of palliative radiotherapy between March 2017 and December 2021. PS was assessed using the Eastern Cooperative Oncology Group (ECOG) scale. Survival duration was calculated from the final day of palliative radiotherapy to death using the Kaplan-Meier method. A total of 35 patients underwent ...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Hitoshi Maemoto Kazuaki Kushi Isoko Owan Takuro Ariga Joichi Heianna Akihiro Nishie Source Type: research
Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In Vitro Cytotoxicity in 2D and 3D Colon Cancer Cell Models
In this study, we tested the anticancer potential of selected cannabinoids CBD (cannabidiol) and its quinone derivative CBD-HQ (cannabidiol hydroquinone), CBG (cannabigerol) and its acid derivative CBG-A (cannabigerolic acid), as well as a combination of CBD+CBG on the colon cancer cell line SW-620. The MTT assay was used to determine the cannabinoids' ability to induce colon cancer cell death. All cannabinoids were cytotoxic at the lowest concentration (3 μg/mL). The half maximal inhibitory concentration (IC50) ranged from 3.90 to 8.24 μg/mL, depending on the substance. Cytotoxicity was confirmed in a 3D spheroidal cell...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Dorota B ęben Oliwia Siwiela Anna Szyjka Micha ł Graczyk Daniel Rzepka Ewa Barg Helena Moreira Source Type: research
Cancers, Vol. 16, Pages 1690: Current and Future Therapeutic Targets for Directed Molecular Therapies in Cholangiocarcinoma
andulski
We conducted a comprehensive review of the current literature of published data, clinical trials (MEDLINE; ncbi.pubmed.com), congress contributions (asco.org; esmo.org), and active recruiting clinical trains (clinicaltrial.gov) on targeted therapies in cholangiocarcinoma. Palliative treatment regimens were analyzed as well as preoperative and perioperative treatment options. We summarized the current knowledge for each mutation and molecular pathway that is or has been under clinical evaluation and discussed the results on the background of current treatment guidelines. We established and recommended targeted ...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Philipp Heumann Andreas Albert Karsten G ülow Denis T ümen Martina M üller Arne Kandulski Tags: Review Source Type: research
Development and validation of impact of early integration of palliative care and oncology(IEI PCO) questionnaire: a survey for medical oncologists and nurses
Many associations have recently recommended early integration of oncology and palliative care for more standard cancer care and better quality of life. We aimed to create a questionnaire to assess the opinion ... (Source: BMC Palliative Care)
Source: BMC Palliative Care - April 26, 2024 Category: Palliative Care Authors: Abdulrahman Abdulaziz Abdullah, Wafaa Mostafa Abd-El-Gawad, Sobhi Mostafa AboSerea, Fatma AbdelShakor Ali and Saima Ali Tags: Research Source Type: research
