Nabumetone and flufenamic acid pose a serious risk to aquatic plants: A study with Chlamydomonas reinhardtii as a model organism
Chemosphere. 2023 Dec 3:140853. doi: 10.1016/j.chemosphere.2023.140853. Online ahead of print.ABSTRACTThe aquatic environment is constantly under threat due to the release of numerous pollutants. Among them, pharmaceuticals constitute a huge and diverse group. Non-steroidal anti-inflammatory drugs (NSAIDs) are increasingly found in water bodies, but knowledge about their potential toxicity is still low. In particular, there is a lack of information about their influences on aquatic plants and algae. We estimated the susceptibility of the microalgae Chlamydomonas reinhardtii to nabumetone (NBT) and flufenamic acid (FFA), fo...
Source: Chemosphere - December 5, 2023 Category: Chemistry Authors: Dominika Kapu ścińska Magdalena Narajczyk Ivan Liakh Bartosz Wielgomas Anna Aksmann Source Type: research
Nabumetone and flufenamic acid pose a serious risk to aquatic plants: A study with Chlamydomonas reinhardtii as a model organism
Chemosphere. 2023 Dec 3:140853. doi: 10.1016/j.chemosphere.2023.140853. Online ahead of print.ABSTRACTThe aquatic environment is constantly under threat due to the release of numerous pollutants. Among them, pharmaceuticals constitute a huge and diverse group. Non-steroidal anti-inflammatory drugs (NSAIDs) are increasingly found in water bodies, but knowledge about their potential toxicity is still low. In particular, there is a lack of information about their influences on aquatic plants and algae. We estimated the susceptibility of the microalgae Chlamydomonas reinhardtii to nabumetone (NBT) and flufenamic acid (FFA), fo...
Source: Chemosphere - December 5, 2023 Category: Chemistry Authors: Dominika Kapu ścińska Magdalena Narajczyk Ivan Liakh Bartosz Wielgomas Anna Aksmann Source Type: research
Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism
In conclusion, our study demonstrated that HSD17B12 is responsible for the formation of MNBO from nabumetone. Together with the evidence for pentoxifylline and S-warfarin reduction, this is the first study to report that HSD17B12, which is known to metabolize endogenous compounds, such as estrone and 3-ketoacyl-CoA, plays a role as a drug-metabolizing enzyme.PMID:36724833 | DOI:10.1016/j.abb.2023.109536 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - February 1, 2023 Category: Biochemistry Authors: Hiroyuki Ichida Tatsuki Fukami Takashi Kudo Kenji Mishiro Shiori Takano Masataka Nakano Gaku Morinaga Akiko Matsui Naoki Ishiguro Miki Nakajima Source Type: research
Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism
In conclusion, our study demonstrated that HSD17B12 is responsible for the formation of MNBO from nabumetone. Together with the evidence for pentoxifylline and S-warfarin reduction, this is the first study to report that HSD17B12, which is known to metabolize endogenous compounds, such as estrone and 3-ketoacyl-CoA, plays a role as a drug-metabolizing enzyme.PMID:36724833 | DOI:10.1016/j.abb.2023.109536 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - February 1, 2023 Category: Biochemistry Authors: Hiroyuki Ichida Tatsuki Fukami Takashi Kudo Kenji Mishiro Shiori Takano Masataka Nakano Gaku Morinaga Akiko Matsui Naoki Ishiguro Miki Nakajima Source Type: research
Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism
In conclusion, our study demonstrated that HSD17B12 is responsible for the formation of MNBO from nabumetone. Together with the evidence for pentoxifylline and S-warfarin reduction, this is the first study to report that HSD17B12, which is known to metabolize endogenous compounds, such as estrone and 3-ketoacyl-CoA, plays a role as a drug-metabolizing enzyme.PMID:36724833 | DOI:10.1016/j.abb.2023.109536 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - February 1, 2023 Category: Biochemistry Authors: Hiroyuki Ichida Tatsuki Fukami Takashi Kudo Kenji Mishiro Shiori Takano Masataka Nakano Gaku Morinaga Akiko Matsui Naoki Ishiguro Miki Nakajima Source Type: research
Precision Medicine in Patients with Differential Diabetic Phenotypes: Novel Opportunities from Network Medicine
CONCLUSION: The interactome [or protein-protein interactions (PPIs)] is a useful tool to identify subtle molecular differences between precise diabetic phenotypes and predict putative novel drugs. Despite being previously unappreciated as T2DM determinants, the growth factor receptor-bound protein 14 (GRB14), calmodulin 2 (CALM2), and protein kinase C-alpha (PRKCA) might have a relevant role in disease pathogenesis. Besides, in silico platforms have suggested that diflunisal, nabumetone, niflumic acid, and valdecoxib may be suitable for the treatment of T1DM; phenoxybenzamine and idazoxan for the treatment of T2DM by impro...
Source: Current Diabetes Reviews - December 24, 2021 Category: Endocrinology Authors: Claudio Napoli Giuditta Benincasa Samer Ellahham Source Type: research
Precision Medicine in Patients with Differential Diabetic Phenotypes: Novel Opportunities from Network Medicine
CONCLUSION: The interactome [or protein-protein interactions (PPIs)] is a useful tool to identify subtle molecular differences between precise diabetic phenotypes and predict putative novel drugs. Despite being previously unappreciated as T2DM determinants, the growth factor receptor-bound protein 14 (GRB14), calmodulin 2 (CALM2), and protein kinase C-alpha (PRKCA) might have a relevant role in disease pathogenesis. Besides, in silico platforms have suggested that diflunisal, nabumetone, niflumic acid, and valdecoxib may be suitable for the treatment of T1DM; phenoxybenzamine and idazoxan for the treatment of T2DM by impro...
Source: Current Diabetes Reviews - December 24, 2021 Category: Endocrinology Authors: Claudio Napoli Giuditta Benincasa Samer Ellahham Source Type: research
Precision Medicine in Patients with Differential Diabetic Phenotypes: Novel Opportunities from Network Medicine
CONCLUSION: The interactome [or protein-protein interactions (PPIs)] is a useful tool to identify subtle molecular differences between precise diabetic phenotypes and predict putative novel drugs. Despite being previously unappreciated as T2DM determinants, the growth factor receptor-bound protein 14 (GRB14), calmodulin 2 (CALM2), and protein kinase C-alpha (PRKCA) might have a relevant role in disease pathogenesis. Besides, in silico platforms have suggested that diflunisal, nabumetone, niflumic acid, and valdecoxib may be suitable for the treatment of T1DM; phenoxybenzamine and idazoxan for the treatment of T2DM by impro...
Source: Current Diabetes Reviews - December 24, 2021 Category: Endocrinology Authors: Claudio Napoli Giuditta Benincasa Samer Ellahham Source Type: research
Precision Medicine in Patients with Differential Diabetic Phenotypes: Novel Opportunities from Network Medicine
CONCLUSION: The interactome [or protein-protein interactions (PPIs)] is a useful tool to identify subtle molecular differences between precise diabetic phenotypes and predict putative novel drugs. Despite being previously unappreciated as T2DM determinants, the growth factor receptor-bound protein 14 (GRB14), calmodulin 2 (CALM2), and protein kinase C-alpha (PRKCA) might have a relevant role in disease pathogenesis. Besides, in silico platforms have suggested that diflunisal, nabumetone, niflumic acid, and valdecoxib may be suitable for the treatment of T1DM; phenoxybenzamine and idazoxan for the treatment of T2DM by impro...
Source: Current Diabetes Reviews - December 24, 2021 Category: Endocrinology Authors: Claudio Napoli Giuditta Benincasa Samer Ellahham Source Type: research
New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases
Mol Med. 2021 Sep 30;27(1):123. doi: 10.1186/s10020-021-00358-4.ABSTRACTAge-related cardiovascular disease is the leading cause of death in elderly populations. Coxibs, including celecoxib, valdecoxib, etoricoxib, parecoxib, lumiracoxib, and rofecoxib, are selective cyclooxygenase-2 (COX-2) inhibitors used to treat osteoarthritis and rheumatoid arthritis. However, many coxibs have been discontinued due to adverse cardiovascular events. COX-2 contains cyclooxygenase (COX) and peroxidase (POX) sites. COX-2 inhibitors block COX activity without affecting POX activity. Recently, quercetin-like flavonoid compounds with OH group...
Source: Molecular Medicine - October 1, 2021 Category: Molecular Biology Authors: Wujun Chen Yingjie Zhong Nuan Feng Zhu Guo Shuai Wang Dongming Xing Source Type: research
New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases
Mol Med. 2021 Sep 30;27(1):123. doi: 10.1186/s10020-021-00358-4.ABSTRACTAge-related cardiovascular disease is the leading cause of death in elderly populations. Coxibs, including celecoxib, valdecoxib, etoricoxib, parecoxib, lumiracoxib, and rofecoxib, are selective cyclooxygenase-2 (COX-2) inhibitors used to treat osteoarthritis and rheumatoid arthritis. However, many coxibs have been discontinued due to adverse cardiovascular events. COX-2 contains cyclooxygenase (COX) and peroxidase (POX) sites. COX-2 inhibitors block COX activity without affecting POX activity. Recently, quercetin-like flavonoid compounds with OH group...
Source: Molecular Medicine - October 1, 2021 Category: Molecular Biology Authors: Wujun Chen Yingjie Zhong Nuan Feng Zhu Guo Shuai Wang Dongming Xing Source Type: research
Molecules, Vol. 26, Pages 3940: Toward Multitasking Pharmacological COX-Targeting Agents: Non-Steroidal Anti-Inflammatory Prodrugs with Antiproliferative Effects
Antonio Garofalo
The antitumor activity of certain anti-inflammatory drugs is often attributed to an indirect effect based on the inhibition of COX enzymes. In the case of anti-inflammatory prodrugs, this property could be attributed to the parent molecules with mechanism other than COX inhibition, particularly through formulations capable of slowing down their metabolic conversion. In this work, a pilot docking study aimed at comparing the interaction of two prodrugs, nabumetone (NB) and its tricyclic analog 7-methoxy-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one (MC), and their common active metabolite 6-methoxy-2-...
Source: Molecules - June 28, 2021 Category: Chemistry Authors: Fedora Grande Francesca Giordano Maria Antonietta Occhiuzzi Carmine Rocca Giuseppina Ioele Michele De Luca Gaetano Ragno Maria Luisa Panno Bruno Rizzuti Antonio Garofalo Tags: Article Source Type: research
Nabumetone induced photogenotoxicity mechanism mediated by ROS generation under environmental UV radiation in human keratinocytes (HaCaT) cell line
This study proposes that sunlight exposure should be avoided by patients using nabumetone and proper guidance should be provided by clinicians regarding photosensitivity of drugs for better safety and efficacy.PMID:33798594 | DOI:10.1016/j.taap.2021.115516 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 2, 2021 Category: Toxicology Authors: Saba Qureshi Sonam Chandra Deepti Chopra Divya Dubey Veena Jain Somendu Kumar Roy Ratan Singh Ray Source Type: research
Nabumetone induced photogenotoxicity mechanism mediated by ROS generation under environmental UV radiation in human keratinocytes (HaCaT) cell line
This study proposes that sunlight exposure should be avoided by patients using nabumetone and proper guidance should be provided by clinicians regarding photosensitivity of drugs for better safety and efficacy.PMID:33798594 | DOI:10.1016/j.taap.2021.115516 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 2, 2021 Category: Toxicology Authors: Saba Qureshi Sonam Chandra Deepti Chopra Divya Dubey Veena Jain Somendu Kumar Roy Ratan Singh Ray Source Type: research
Presence or absence of microbiome modulates the response of mice organism to administered drug nabumetone
Physiol Res. 2020 Dec 31;69(Suppl 4):S583-S594. doi: 10.33549/physiolres.934607.ABSTRACTThe gut microbiota provides a wide range of beneficial functions for the host, and has an immense effect on the host's health status. The presence of microbiome in the gut may often influence the effect of an orally administered drug. Molecular mechanisms of this process are however mostly unclear. We investigated how the effect of a nonsteroidal drug nabumetone on expression of drug metabolizing enzymes (DMEs) in mice intestine and liver is changed by the presence of microbiota, here, using the germ free (GF) and specific pathogen free...
Source: Physiological Research - March 1, 2021 Category: Physiology Authors: L Jourov á B Li šková K Ln ěničková N Zemanov á P Anzenbacher P Hermanov á T Hudcovic H Koz áková E Anzenbacherov á Source Type: research
