Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism

In conclusion, our study demonstrated that HSD17B12 is responsible for the formation of MNBO from nabumetone. Together with the evidence for pentoxifylline and S-warfarin reduction, this is the first study to report that HSD17B12, which is known to metabolize endogenous compounds, such as estrone and 3-ketoacyl-CoA, plays a role as a drug-metabolizing enzyme.PMID:36724833 | DOI:10.1016/j.abb.2023.109536

Source: Archives of Biochemistry and Biophysics - February 1, 2023 Category: Biochemistry Authors: Hiroyuki Ichida Tatsuki Fukami Takashi Kudo Kenji Mishiro Shiori Takano Masataka Nakano Gaku Morinaga Akiko Matsui Naoki Ishiguro Miki Nakajima Source Type: research