Fight Aging! Newsletter, December 12th 2022
In conclusion, selective removal of senescent dermal fibroblasts can improve the skin aging phenotype, indicating that BPTES may be an effective novel therapeutic agent for skin aging.
Non-Dividing Neurons Do In Fact Become Senescent, Impairing Brain Function
https://www.fightaging.org/archives/2022/12/non-dividing-neurons-do-in-fact-become-senescent-impairing-brain-function/
Cellular senescence is generally thought of as a characteristic of replicating cells; it is an end state reached when telomeres, reduced in length with each cell division, become too short. This is followed by programmed cell death...
Source: Fight Aging! - December 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Increased Expression of Lysosomal Enzyme NAGLU Improves Health in Flies
Lysosomes are the destination for excess and damaged proteins and structures in the cell. A lysosome is a membrane-wrapped collection of enzymes capable of breaking down near everything it encounters into the raw materials a cell uses to manufacture new molecular machinery. Lysosomal function is known to decline with age, and improved lysosomal function might be expected to improve long-term health prospects. Here, researchers look at one specific lysosomal enzyme that is known to exhibit higher levels in human centenarians, and find that it improves health in flies. There is extension of life, but the effect size is so sm...
Source: Fight Aging! - December 6, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
TBTAM DIGEST – Nov 30, 2022
Cross-publishing here for those without a substack subscription (Which is free)…
Happy almost December! Hope you had a great Thanksgiving and are enjoying the in-between holiday time. Here’s what’s been going on in my neck of the woods….
What I’ve been cooking on the blog
Farro with Oyster Mushrooms and Onions – You call it Thanksgiving. I call it a chance for a sweet potato bake-off.
Spanish Stuffed Peppers – An original recipe from The Blog that Ate Manhattan. With a little help from my friends (and family)…
Where I Ate
Valley Green Inn in the Wissahickon Valley.&n...
Source: The Blog That Ate Manhattan - December 1, 2022 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Uncategorized Source Type: blogs
Farro with Oyster Mushrooms & Onions
One of my goals in retirement is to shop more at the farm markets, in order to support local farmers and eat more seasonally. It’s something I could never find the time to do when I was working. (Though I have friends who managed to do so even with full time jobs, so really, what was my excuse?…)
Although I adore the Union Square Green Market, it’s a bit of a schlep to visit on a regular basis. Thankfully, we have a wonderful farmer’s market every Sunday here on the Upper West Side, on Columbus Avenue just behind the Museum of Natural History. That’s where some lovely-looking oyster mushro...
Source: The Blog That Ate Manhattan - November 21, 2022 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Pasta Rice & Potatoes Vegetables Vegetarian Farro Food waste leftovers mushrooms Oyter Mushrooms Source Type: blogs
Insights From a Plant Medicine Journey
I had a fascinating weekend of plant medicine journeying that involved taking several different substances: kanna, white lily, psilocybin (mushrooms), and ayahuasca… mostly the latter two. I had only done ayahuasca before (3 years ago for 4 nights in a row in Costa Rica). I shared the insights from that previous experience here: Lessons From Ayahuasca. In this post I’ll share my experience of this recent journey while it’s still fresh in mind and heart. If you’re short on time and only want to skim the insights instead of reading the details about what it was like, feel free to scroll down to the sectio...
Source: Steve Pavlina's Personal Development Blog - November 14, 2022 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Health Source Type: blogs
Home Remedies for High Blood Pressure
Lower high blood pressure with these effective home remedies that are easy to apply, whether you’re dealing with mild or more severe cases of the condition.
If you’re searching for natural ways to lower your blood pressure, a few home remedies may help.
From making some lifestyle changes to eating mindfully, these tips can help you get your numbers down.
Talk to your doctor before trying new treatments, and read for more information.
Quick Summary
Regular exercise can help lower blood pressure by making the heart stronger and more efficient.
The DASH diet is a tried-and-tested eating pa...
Source: The EMT Spot - November 1, 2022 Category: Emergency Medicine Authors: bpscore-sibera Tags: Guides Blood Pressure Source Type: blogs
Maccheroni alla bolognese
Before there was Stanley Tucci’s Searching for Italy, there was Regional Italian Cuisine, a cookbook tour of Italy’s regions through its foods and recipes. While Stanley’s show is a light aperitivo, this book is the ten course meal, with recipes for dishes that will make you feel like you’re one of the Famiglia.
Each chapter of Regional Italian Cuisine focuses on a different region of Italy, summarizing in sequential, gorgeous two-page spreads of perfectly balanced text and photos its climate, crops, food specialties, regional events and sights to see. It then follows with short, well-written ...
Source: The Blog That Ate Manhattan - October 13, 2022 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Pasta Rice & Potatoes Bolognese Bolognese sauce Emilia-Romagna italian Italy Italy regional cuisine Meat sauce Ragu recipe Regional Italian Cuisine Source Type: blogs
Fight Aging! Newsletter, September 19th 2022
Conclusion
Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life.
Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In the Matter of Human Longevity There Will Be Opportunists and Alchemists
I suspect that a sizable, earnest community of opportunists and alchemists focused on anti-aging and longevity will continue to exist even as we transition from an era in which the only approaches to aging (beyond exercise and calorie restriction) were snake oil, the only service providers frauds, to an era in which therapies to slow aging and produce rejuvenation actually exist and are robustly proven to do what they say on the label. Will reliable, low-cost ways to measure biological age drive out the true believers who try whatever intervention is hyped, fail to gain scientific understanding, and fail to use adequate me...
Source: Fight Aging! - September 16, 2022 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Digital Clothing, Biofashion And Smart Outfits – The Future Of Fashion
Fast fashion is not only unsustainable but also means an unbearable burden to the planet. The situation is ripe for change. Could lab-grown leather and other novel ways of synthetic garment production, biofashion or digital clothing show the way to an alternative future for the apparel industry? Is there a chance of improving our attitude towards clothing items by adding more value, new functionality?
From Burda to the unsustainable downward spiral of fast fashion
When our grandmothers in the 1950s wanted to dress according to the latest trend, they bought the Burda Magazine alongside some fabric and used the fam...
Source: The Medical Futurist - July 21, 2022 Category: Information Technology Authors: berci.mesko Tags: Biotechnology Health Sensors & Trackers design digital future Healthcare wearables fashion fast fashion digital clothing digital clothes artificial leather artificial material synthetic biofashion Source Type: blogs
The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
The objective most consistent with recent operations is to conquer Luhansk, Donetsk, and Kherson, with a view to their eventual annexation and Russification. But not only are they some way from achieving that (w ith much of Donetsk still in Ukrainian hands and the Russia position in Kherson highly contested) it would also require an explicit Ukrainian surrender for it to serve as the basis for a declaration of victory. That will not be forthcoming.-----https://www.afr.com/world/europe/how-britain-giggled-its-way-into-crisis-20220710-p5b0giHow Britain giggled its way into crisisBoris Johnson has exposed the costs of Britain...
Source: Australian Health Information Technology - July 21, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
An Analysis of the Regulatory Framework Applicable to Products Obtained from Mushroom and Mycelium
This report concerns food law provisions applicable to... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - July 19, 2022 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Mapping ‘psychedelic trips’ in the brain to better direct their therapeutic effects
This article was originally published on The Conversation.
To learn more:
Why MDMA-assisted psychotherapy may become an FDA-approved treatment for PTSD within 2 years
Next: Psychedelic-assisted psychotherapy?
The post Mapping ‘psychedelic trips’ in the brain to better direct their therapeutic effects appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - April 4, 2022 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health academic research anxiety artificial intelligence brain regions cognitive-flexibility depression psychedelics psychiatric conditions psychotropic drugs therapeutic treat psychiatric conditions Source Type: blogs
This Many Mushrooms Lowers Depression Risk By One-Third
The antioxidants in mushrooms likely help to prevent against various mental illnesses. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 2, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Depression Source Type: blogs
