Multiple Endocrine Neoplasia Syndrome Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Management of Type 2 Diabetes Mellitus With Noninsulin Pharmacotherapy
Am Fam Physician. 2024 Apr;109(4):333-342.ABSTRACTType 2 diabetes mellitus is a chronic disease that is increasing in global prevalence. An individualized approach to pharmacotherapy should consider costs, benefits beyond glucose control, and adverse events. Metformin is the first-line therapy due to its low cost and effectiveness. Sulfonylureas and thiazolidinediones are additional low-cost oral hypoglycemic classes available in the United States; however, evidence shows variability in weight gain and hypoglycemia. Thiazolidinediones increase fluid retention and are not recommended in patients with New York Heart Associat...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Elizabeth M Vaughan Zuleica M Santiago-Delgado Source Type: research

Familial states of primary hyperparathyroidism: an update
AbstractBackgroundFamilial primary hyperparathyroidism (PHPT) includes syndromic and non-syndromic disorders. The former are characterized by the occurrence of PHPT in association with extra-parathyroid manifestations and includes multiple endocrine neoplasia (MEN) types 1, 2, and 4 syndromes, and hyperparathyroidism –jaw tumor (HPT–JT). The latter consists of familial hypocalciuric hypercalcemia (FHH) types 1, 2 and 3, neonatal severe primary hyperparathyroidism (NSHPT), and familial isolated primary hyperparathyroidism (FIHP). The familial forms of PHPT show different levels of PHPT penetrance, developing earlier and...
Source: Journal of Endocrinological Investigation - April 18, 2024 Category: Endocrinology Source Type: research

A cohort study of CNS tumors in Multiple Endocrine Neoplasia Type 1
CONCLUSIONS: Incidence of each CNS tumor was higher in the MEN1 population than in the French general population. Meningiomas and ependymomas should be considered part of the MEN1 syndrome, but somatic molecular data are missing to conclude for astrocytomas and schwannomas.PMID:38630553 | DOI:10.1158/1078-0432.CCR-23-3308 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 17, 2024 Category: Cancer & Oncology Authors: Thomas Graillon Pauline Romanet Clara Camilla Camille Gelin Romain Appay Catherine Roche Arnaud Lagarde Gr égory Mougel Kaissar Farah Ma ëlle Le Bras Julien Engelhardt Michel Kalamarides Matthieu Peyre Aymeric Amelot Evelyne Emery Elsa Magro Helene Cebu Source Type: research

Multiple endocrine neoplasia type 1 with MEN1 variant of unknown significance, in a patient after the diagnosed of pancreatic neuroendocrine neoplasia
AbstractDuodenopancreatic neuroendocrine neoplasia (DP-NEN) is in approximately 10% of cases of multiple endocrine neoplasia type 1 (MEN1). We encountered a case in which the onset of NEN led to suspicion and diagnosis of MEN1. Although genetic testing showedMEN1 variant of uncertain significance (VUS), we considered it pathological from the clinical course, promoting the provision of genetic counseling and screening for relatives. MEN1 has a variety of clinical manifestations, and DP-NENs are the second-most common manifestation after primary hyperparathyroidism (pHPT). It is important to assume that MEN1 is an underlying...
Source: International Cancer Conference Journal - April 16, 2024 Category: Cancer & Oncology Source Type: research

Evaluation and Surgical Management of Multiple Endocrine Neoplasias
Multiple endocrine neoplasia (MEN) syndromes are rare autosomal dominant diseases that are associated with a mixture of both endocrine and non-endocrine tumors. Traditionally, there are 2 types of MEN that have unique clinical associations: MEN 1 (parathyroid hyperplasia, pancreatic neuroendocrine tumors, and pituitary tumors) and MEN 2 (medullary thyroid carcinoma and pheochromocytoma), which is further classified into MEN 2A (adds parathyroid adenomas) and 2B (adds ganglioneuromas and marfanoid habitus). Many of the endocrine tumors are resected surgically, and the pre, intra, and postoperative management strategies used...
Source: Surgical Clinics of North America - April 3, 2024 Category: Surgery Authors: C. Corbin Frye, Taylor C. Brown, John A. Olson Source Type: research

The lesion detection rate of Ga ‐68 DOTATATE PET/MR in multiple endocrine neoplasia type 1
ConclusionThe combination of Ga-68 DOTATATE PET and MRI demonstrated a higher detection rate and may be more useful in the work-up of MEN1 providing a panoramic view of MEN1-related lesions. To increase the identification of MEN1-associated neuroendocrine lesions in the parathyroid gland, approaches other than Ga-68 DOTATATE PET/MRI should be used. (Source: Journal of Medical Imaging and Radiation Oncology)
Source: Journal of Medical Imaging and Radiation Oncology - April 2, 2024 Category: Radiology Authors: Jing Gao, Chang Liu, Jinxin Zhou, Yu Pan, Yifan Zhang Tags: Medical Imaging —Original Article Source Type: research

Current prospects of hereditary adrenal tumors: towards better clinical management
AbstractAdrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL) are two rare types of adrenal gland malignancies. Regarding hereditary tumors, some patients with ACC are associated with with Li-Fraumeni syndrome (LFS), and those with PPGL with multiple endocrine neoplasia type 2. Recent studies have expanded this spectrum to include other types of hereditary tumors, such as Lynch syndrome or familial adenomatous polyposis. Individuals harboring germlineTP53 pathogenic variants that cause LFS have heterogeneous phenotypes depending on the respective variant type. As an example, R337H variant found in Brazil...
Source: Hereditary Cancer in Clinical Practice - March 26, 2024 Category: Cancer & Oncology Source Type: research

Developing Dynamic Structure-Based Pharmacophore and ML-Trained QSAR Models for the Discovery of Novel Resistance-Free RET Tyrosine Kinase Inhibitors
In this study, a structure-based dynamic pharmacophore-driven approach using E-pharmacophore modeling from molecular dynamics trajectories is proposed to select low energy favorable hypotheses, and ML-trained QSAR models to predict pIC50 values of compounds. For this aim, extensive small molecule libraries were screened using developed ligand-based models and potent compounds which are capable of inhibiting RET activation were proposed.PMID:38523069 | DOI:10.1002/cmdc.202300644 (Source: ChemMedChem)
Source: ChemMedChem - March 24, 2024 Category: Chemistry Authors: Ehsan Sayyah Lalehan Oktay H üseyin Tunç Serdar Durdagi Source Type: research

Jeffrey A. Norton and the Multiple Endocrine Neoplasia Syndromes
CONCLUSION: It is most fitting that the Stanford University School of Medicine has assembled a group of Jeffrey Norton's colleagues in academic medicine and surgery to pay tribute to his achievements as a surgical scientist.PMID:38494562 | DOI:10.1245/s10434-024-15079-1 (Source: Ann Oncol)
Source: Ann Oncol - March 18, 2024 Category: Cancer & Oncology Authors: Samuel A Wells Source Type: research

Multiple endocrine neoplasia type 2 - solving the puzzle
J Family Med Prim Care. 2023 Dec;12(12):3402-3405. doi: 10.4103/jfmpc.jfmpc_328_23. Epub 2023 Dec 21.ABSTRACTMultiple endocrine neoplasia (MEN) are tumors that involve two or more endocrine glands. It can also involve other organs and tissues as well. Out of the four types of MEN type 2 is the most common. In MEN type 2 or type 3, paraganglioma is rare, but in our case, medullary thyroid carcinoma (MTC), hyperparathyroidism, and pheochromocytoma were associated with the paraganglioma.PMID:38361883 | PMC:PMC10866221 | DOI:10.4103/jfmpc.jfmpc_328_23 (Source: Primary Care)
Source: Primary Care - February 16, 2024 Category: Primary Care Authors: Ajay K Jha Ashok Sunder Sridhar Pradhan Source Type: research

Multiple bronchial carcinoids associated with Cowden syndrome
We present a case of a 46-year-old male patient diagnosed with testicular seminoma and follicular thyroid cancer in his medical history. Our patient met the clinical diagnostic criteria of Cowden syndrome. Genetic analysis established the clinical diagnosis; a known heterozygousPTEN mutation was detected [PTEN (LRG_311t1)c.388 C > T (p.Arg130Ter)]. Incidentally, he was also seen with multiple pulmonary lesions during his oncological follow-up. A video-assisted thoracoscopic left lingula wedge resection and later resections from the right lung were performed. Histological findings revealed typical pulmonary carci...
Source: Endocrine - February 14, 2024 Category: Endocrinology Source Type: research