Comparing Nodal with Primary Tumor Desmoplasia Uncovers Metastatic Patterns in MEN 2B
Eur J Endocrinol. 2023 Dec 26:lvad177. doi: 10.1093/ejendo/lvad177. Online ahead of print.ABSTRACTWhile primary tumor desmoplasia is a powerful biomarker of node metastases in sporadic medullary thyroid cancer (MTC), information for hereditary MTC is sparse. This proof-of-concept study, comprising three consecutive children with multiple endocrine neoplasia 2B, evaluated simultaneously the metastatic behavior of multiple primary thyroid tumors of disparate size and extent of desmoplasia within patients. Altogether, MTC typically involved the ipsilateral central neck before spreading to the ipsilateral lateral and the contr...
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Andreas Machens Claudia Bensch Claudia Wickenhauser Henning Dralle Kerstin Lorenz Source Type: research

Comparing Nodal with Primary Tumor Desmoplasia Uncovers Metastatic Patterns in MEN 2B
Eur J Endocrinol. 2023 Dec 26:lvad177. doi: 10.1093/ejendo/lvad177. Online ahead of print.ABSTRACTWhile primary tumor desmoplasia is a powerful biomarker of node metastases in sporadic medullary thyroid cancer (MTC), information for hereditary MTC is sparse. This proof-of-concept study, comprising three consecutive children with multiple endocrine neoplasia 2B, evaluated simultaneously the metastatic behavior of multiple primary thyroid tumors of disparate size and extent of desmoplasia within patients. Altogether, MTC typically involved the ipsilateral central neck before spreading to the ipsilateral lateral and the contr...
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Andreas Machens Claudia Bensch Claudia Wickenhauser Henning Dralle Kerstin Lorenz Source Type: research

Comparing Nodal with Primary Tumor Desmoplasia Uncovers Metastatic Patterns in MEN 2B
Eur J Endocrinol. 2023 Dec 26:lvad177. doi: 10.1093/ejendo/lvad177. Online ahead of print.ABSTRACTWhile primary tumor desmoplasia is a powerful biomarker of node metastases in sporadic medullary thyroid cancer (MTC), information for hereditary MTC is sparse. This proof-of-concept study, comprising three consecutive children with multiple endocrine neoplasia 2B, evaluated simultaneously the metastatic behavior of multiple primary thyroid tumors of disparate size and extent of desmoplasia within patients. Altogether, MTC typically involved the ipsilateral central neck before spreading to the ipsilateral lateral and the contr...
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Andreas Machens Claudia Bensch Claudia Wickenhauser Henning Dralle Kerstin Lorenz Source Type: research

Comparing Nodal with Primary Tumor Desmoplasia Uncovers Metastatic Patterns in MEN 2B
Eur J Endocrinol. 2023 Dec 26:lvad177. doi: 10.1093/ejendo/lvad177. Online ahead of print.ABSTRACTWhile primary tumor desmoplasia is a powerful biomarker of node metastases in sporadic medullary thyroid cancer (MTC), information for hereditary MTC is sparse. This proof-of-concept study, comprising three consecutive children with multiple endocrine neoplasia 2B, evaluated simultaneously the metastatic behavior of multiple primary thyroid tumors of disparate size and extent of desmoplasia within patients. Altogether, MTC typically involved the ipsilateral central neck before spreading to the ipsilateral lateral and the contr...
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Andreas Machens Claudia Bensch Claudia Wickenhauser Henning Dralle Kerstin Lorenz Source Type: research

Comparing nodal with primary tumor desmoplasia uncovers metastatic patterns in multiple endocrine neoplasia 2B
CONCLUSION: This proof-of-concept study suggests that primary tumor desmoplasia is an equally powerful biomarker of node metastasis in hereditary MTC.PMID:38147465 | DOI:10.1093/ejendo/lvad177 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Andreas Machens Claudia Bensch Claudia Wickenhauser Henning Dralle Kerstin Lorenz Source Type: research

Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review
CONCLUSIONS: The incidence of PTC/MTC has been increasing over the past 30 years. The etiology of PTC/MTC forms is still unknown, and although this simultaneous occurrence could be only a coincidence, we cannot exclude the hypothesis of a shared genetic origin.PMID:38132379 | DOI:10.3390/curroncol30120745 (Source: Current Oncology)
Source: Current Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Poupak Fallahi Armando Patrizio Giulio Stoppini Giusy Elia Francesca Ragusa Sabrina Rosaria Paparo Eugenia Balestri Valeria Mazzi Chiara Botrini Gilda Varricchi Salvatore Ulisse Marco Ghionzoli Alessandro Antonelli Silvia Martina Ferrari Source Type: research

Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review
CONCLUSIONS: The incidence of PTC/MTC has been increasing over the past 30 years. The etiology of PTC/MTC forms is still unknown, and although this simultaneous occurrence could be only a coincidence, we cannot exclude the hypothesis of a shared genetic origin.PMID:38132379 | PMC:PMC10742226 | DOI:10.3390/curroncol30120745 (Source: Current Oncology)
Source: Current Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Poupak Fallahi Armando Patrizio Giulio Stoppini Giusy Elia Francesca Ragusa Sabrina Rosaria Paparo Eugenia Balestri Valeria Mazzi Chiara Botrini Gilda Varricchi Salvatore Ulisse Marco Ghionzoli Alessandro Antonelli Silvia Martina Ferrari Source Type: research