Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Thoughts on Micronutrient Intake During Calorie Restriction
Despite the considerable attention given to calorie restriction and intermittent fasting in the research community, there is very little formalism applied to the practice in humans. The few clinical trials conducted to date have had to pick their own protocols, and it is only comparatively recently that the fasting mimicking diet was developed to plant a flag on one specific implementation. The challenge here is that it is difficult to monetize calorie restriction and fasting, and thus there is no push towards standardization or more detailed assessment of variant protocols from any of the usual parties who might otherwise...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aspects of Skin Aging Encourage Metastasis in Melanoma
There are many ways in which the aging of tissue makes cancer both more likely to occur and more aggressive once it does occur. Here researchers focus in on specific changes in aged skin tissue that make melanoma cancers more likely to become metastatic and spread to other organs. Interestingly, it is an indirect effect on cell signaling that is mediated by increased stiffness of the skin extracellular matrix, an issue in many aging tissues that has many root causes, not just the one noted here. Nonetheless, if metastasis could be shut down, then cancer would become a much more tractable problem, particularly if control of...
Source: Fight Aging! - March 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Collagen, wrinkles, and ageing skin
Collagen is a protein that plays a crucial role in maintaining the structure, firmness, and elasticity of the skin. As we age, several changes occur in the collagen of our skin, contributing to the visible signs of ageing, such as the appearance of wrinkles.
Here are some key aspects of how collagen changes with age:
Decreased Production: The synthesis of collagen decreases with age, leading to a reduction in the overall amount of collagen in the skin. This reduced production is influenced by both genetic and environmental factors, such as sun exposure and lifestyle choices, like smoking and alcohol consumption. a balanced...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 12, 2023 Category: Science Authors: David Bradley Tags: Health and Medicine Source Type: blogs
Mineral Moon
A quick glance at the moon in the night sky and you might imagine the surface is fifty shades of grey. But, take a photo, preferably with a telescope or a big zoom lens and you can process the image to bring out the colours in the surface. These colours essentially represent different regions of minerals scattering sunlight in different ways. So with just the right kind of enhancement you can create a geological map of the moon.
I’d heard about this technique some time ago, but hadn’t given it much thought since. But, the moon was lovely and bright last night, waxing gibbous, not full, and I got a quick snap at...
Source: David Bradley Sciencebase - Songs, Snaps, Science - October 25, 2023 Category: Science Authors: David Bradley Tags: Astronomy Photography Source Type: blogs
Malnutrition Can Impact Wound Healing
Malnutrition can have a significant impact on wound healing. Proper wound healing is a complex process that involves various cellular and biochemical reactions. When the body is malnourished, it lacks the essential nutrients necessary for these processes, which can lead to delayed or impaired wound healing. Here are some key relationships between malnutrition and wound healing:
1. Protein Deficiency: Protein is crucial for tissue repair and the production of collagen, which is essential for wound healing. Malnourishment, especially a lack of adequate protein intake, can lead to a delay in wound closure and reduced tensile ...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - October 2, 2023 Category: Geriatrics Authors: Jeffrey M Levine Tags: An Aging World Featured Medical Articles Geriatric Medicine Long-Term Care Pressure Injuries & Wound Care bedsore bedsores decubiti decubitus ulcer end-of-life care geriatrics gerontology Improving Medical Care Jeff Levine MD J Source Type: blogs
Vitamins and Wound Healing
Wound healing is a complex biological process that involves inflammation, tissue formation, and tissue remodeling. Vitamin supplements can play a role in wound healing by supporting various aspects of the body’s natural healing processes. Here are some key vitamins and minerals that are important for wound healing:
Vitamin C: Vitamin C, also known as ascorbic acid, is essential for collagen synthesis, a protein that helps in the formation of skin, blood vessels, and connective tissue. Collagen is a crucial component of wound healing. Adequate vitamin C intake can promote tissue repair and reduce the risk of infectio...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - September 9, 2023 Category: Geriatrics Authors: Jeffrey M Levine Tags: Geriatric Medicine Pressure Injuries & Wound Care aging skin bedsore bedsores decubiti decubitus ulcer geriatrics gerontology Healthcare Quality Improving Medical Care Jeff Levine MD Jeffrey M Levine MD Nursing Homes pressure s Source Type: blogs
Eggs And High Blood Pressure: Decoding The Dietary Dilemma
Conclusion
In navigating the winding road of managing high blood pressure, several key points emerge. Eggs, while a source of ongoing debate, can form part of a balanced diet for most people. It’s essential, though, to consider your entire dietary pattern, emphasizing heart-healthy choices like those found in the DASH and Mediterranean diets.
Avoiding processed meats and sugary breakfast options, while incorporating nutrient-dense foods, can significantly impact your blood pressure management. But remember, it’s not all about diet. A comprehensive approach, involving regular physical activity, stress mana...
Source: The EMT Spot - July 21, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Yoghurt: A Delicious Solution To High Blood Pressure?
Conclusion
In a nutshell, the humble pot of yoghurt could be a powerful tool in the fight against high blood pressure.
From its impressive mineral content to the potential blood-pressure-lowering action of its amino acids, yoghurt has proven to be more than just a tasty snack.
However, as we’ve learned from Dr. Lee, the type and quantity of yoghurt we consume matters.
The takeaway?
Dietary choices can significantly impact our health, making conscious consumption essential.
Now, you might view that bowl of yoghurt in a new light, not only for its delicious taste but also for its potential health-...
Source: The EMT Spot - July 16, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
In Other Words: What ’s It Mean to Be Organic?
The word organic is often used to talk about fruits and vegetables that have been produced in a specific way, typically without the use of synthetic fertilizers and pesticides. But to chemists, organic refers to carbon-containing compounds that are the basis for all living organisms. Ironically, the chemicals prohibited in the farming of organic produce are usually organic molecules.
Credit: NIGMS.
Organic chemists study, create, and explore carbon-containing molecules. Most organic molecules contain carbon and hydrogen, but they can also include other elements like nitrogen, oxygen, phosphorus, and more. Organic comp...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 12, 2023 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology In Other Words Source Type: blogs
Not the Last of Them
BY KIM BELLARD
I’m seeing two conflicting yet connected visions about the future. One is when journalist David Wallace-Wells says we might be in for “golden age for medicine,” with CRISPR and mRNA revolutionizing drug development. The second is the dystopian HBO hit “The Last of Us,” in which a fungal infection has turned much of the world’s population into zombie-like creatures.
The conflict is clear but the connection not so much. Mr. Wallace-Wells never mentions fungi in his article, but if we’re going to have a golden age of medicine, or if we want to avoid a global fungal outbreak, we better be p...
Source: The Health Care Blog - June 27, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Fungal Infections Kim Bellard Medical School Source Type: blogs
Not The Last of Them
By KIM BELLARD
I’m seeing two conflicting yet connected visions about the future. One is when journalist David Wallace-Wells says we might be in for “golden age for medicine,” with CRISPR and mRNA revolutionizing drug development. The second is the dystopian HBO hit “The Last of Us,” in which a fungal infection has turned much of the world’s population into zombie-like creatures.
The conflict is clear but the connection not so much. Mr. Wallace-Wells never mentions fungi in his article, but if we’re going to have a golden age of medicine, or if we want to avoid a global fungal outbreak, we better be pay...
Source: The Health Care Blog - June 27, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Fungi Golden Age of Medicine Kim Bellard Source Type: blogs
Shelf-Stable Breast Milk Powder: Interview with Dr. Vansh Langer, CEO at BBy
BBy, a medtech company based in New York, has developed a spray drying method that hospitals can use to process human breast milk into a shelf-stable powder. Human breast milk is an incredibly important source of nutrition for neonates in intensive care units (NICUs). At present, human donor milk is frozen and must be defrosted prior to use in such facilities. This is highly labor intensive for staff and is very wasteful, as excess defrosted milk must be thrown away and large freezers use a lot of electricity.
The spray drying technology developed by BBy converts human breast milk into a shelf-stable dry powder that can...
Source: Medgadget - June 26, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Pediatrics BByCares breast milk Source Type: blogs
What to do about problematic medication taking?
Welcome to another episode of BDI Briefs! Our aim with BDI Briefs is to take a brief look at important issues about the emotional side of diabetes.In this short discussion, Scott, Bill, and Susan explore problematic medication taking and what you can do about it. You may be surprised by some insights – I know I was! Enjoy! And please let us know what you think and what you’d like to hear more about. And remember to subscribe to BDI’s YouTube channel!
Detailed show notes and transcript
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Source: Scott's Diabetes Blog - June 21, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
