Clinical Implications of Genomic Profile in Waldenstr öm Macroglobulinemia
With the increasing availability of sequencing techniques and new polymerase chain reaction-based methods, data regarding the genomic profile of Waldenstr öm macroglobulinemia (WM) are being continuously analyzed and reproduced. MYD88 and CXCR4 mutations are highly prevalent in all the stages of WM, including the early IgM monoclonal gammopathy of undetermined significance or a more advanced stage, such as smoldering WM. Thus, there is a need to defi ne genotypes before starting either standard treatment regimens or clinical trials. Here, we review the genomic profile of WM and its clinical implications while focusing on ...
Source: Hematology/Oncology Clinics of North America - May 19, 2023 Category: Cancer & Oncology Authors: David F. Moreno, Carlos Fern ández de Larrea Source Type: research
A case of systemic amyloidosis showing papular/nodular lesions due to Waldenstr öm's macroglobulinemia
Key Clinical MessageThis case report provides evidence that Waldenstr öm's macroglobulinemia may cause cutaneous manifestations represented as papules/nodules through the development of light chain amyloidosis. Here, we report a case of a 67-year-old man. (Source: Clinical Case Reports)
Source: Clinical Case Reports - May 16, 2023 Category: General Medicine Authors: Yumeno Toma,
Yoshimasa Nobeyama,
Hiroyuki Matsuzaki,
Ken ‐ichi Yasuda,
Akihiko Asahina Tags: CASE REPORT Source Type: research
Novel Agents in Waldenstr öm Macroglobulinemia
Owing to the indolent nature of Waldenstr öm macroglobulinemia, most patients experience a prolonged life expectancy, although many lines of therapy will likely be required to maintain disease control. Despite the currently available therapies, most patients will develop intolerance or resistance to multiple treatments. Therefore, new ther apeutic options are being developed with a focus on targeted agents, such as novel Bruton tyrosine kinase (BTK) inhibitors and BTK degraders, as well as C-X-C chemokine receptor type 4, mucosa-associated lymphoid tissue translocation protein 1, and interleukin-1 receptor-associated kina...
Source: Hematology/Oncology Clinics of North America - May 16, 2023 Category: Cancer & Oncology Authors: Shayna Sarosiek, Jorge J. Castillo Source Type: research
Minimal residual disease status improved the response evaluation in patients with Waldenstr öm’s macroglobulinemia
DiscussionMRD status assessed by MFC is an independent prognostic factor for PFS in patients with WM, and its determination could improve the precision of response evaluation, especially in patients who achieved PR. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 10, 2023 Category: Allergy & Immunology Source Type: research
Detection of serum M-protein in acetonitrile pecipitates by MALDI-TOF mass spectrometry: A novel, low-cost methodology
CONCLUSIONS: This study demonstrates the feasibility of qualitatively identifying M-protein without the need for antibody-based immunoenrichment, making the technique cost-effective.PMID:37158306 | DOI:10.1177/00045632231174144 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 9, 2023 Category: Biochemistry Authors: Nikita Mehra Gopal Gopisetty Jayavelu Subramani Sariga Dhanasekar Arivazhagan Rajamanickam Jayachandran Perumal Kalaiyarasi Parathan Karunakaran Krishnarathinam Kannan Swaminathan Rajaraman Thangarajan Rajkumar Source Type: research
Detection of serum M-protein in acetonitrile pecipitates by MALDI-TOF mass spectrometry: A novel, low-cost methodology
CONCLUSIONS: This study demonstrates the feasibility of qualitatively identifying M-protein without the need for antibody-based immunoenrichment, making the technique cost-effective.PMID:37158306 | DOI:10.1177/00045632231174144 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 9, 2023 Category: Biochemistry Authors: Nikita Mehra Gopal Gopisetty Jayavelu Subramani Sariga Dhanasekar Arivazhagan Rajamanickam Jayachandran Perumal Kalaiyarasi Parathan Karunakaran Krishnarathinam Kannan Swaminathan Rajaraman Thangarajan Rajkumar Source Type: research
Detection of serum M-protein in acetonitrile pecipitates by MALDI-TOF mass spectrometry: A novel, low-cost methodology
CONCLUSIONS: This study demonstrates the feasibility of qualitatively identifying M-protein without the need for antibody-based immunoenrichment, making the technique cost-effective.PMID:37158306 | DOI:10.1177/00045632231174144 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 9, 2023 Category: Biochemistry Authors: Nikita Mehra Gopal Gopisetty Jayavelu Subramani Sariga Dhanasekar Arivazhagan Rajamanickam Jayachandran Perumal Kalaiyarasi Parathan Karunakaran Krishnarathinam Kannan Swaminathan Rajaraman Thangarajan Rajkumar Source Type: research
Detection of serum M-protein in acetonitrile pecipitates by MALDI-TOF mass spectrometry: A novel, low-cost methodology
CONCLUSIONS: This study demonstrates the feasibility of qualitatively identifying M-protein without the need for antibody-based immunoenrichment, making the technique cost-effective.PMID:37158306 | DOI:10.1177/00045632231174144 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 9, 2023 Category: Biochemistry Authors: Nikita Mehra Gopal Gopisetty Jayavelu Subramani Sariga Dhanasekar Arivazhagan Rajamanickam Jayachandran Perumal Kalaiyarasi Parathan Karunakaran Krishnarathinam Kannan Swaminathan Rajaraman Thangarajan Rajkumar Source Type: research
Detection of serum M-protein in acetonitrile pecipitates by MALDI-TOF mass spectrometry: A novel, low-cost methodology
CONCLUSIONS: This study demonstrates the feasibility of qualitatively identifying M-protein without the need for antibody-based immunoenrichment, making the technique cost-effective.PMID:37158306 | DOI:10.1177/00045632231174144 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - May 9, 2023 Category: Biochemistry Authors: Nikita Mehra Gopal Gopisetty Jayavelu Subramani Sariga Dhanasekar Arivazhagan Rajamanickam Jayachandran Perumal Kalaiyarasi Parathan Karunakaran Krishnarathinam Kannan Swaminathan Rajaraman Thangarajan Rajkumar Source Type: research
Case report: Circulating tumor DNA technology displays temporal and spatial heterogeneity in Waldenstr öm macroglobulinemia during treatment with < em > BTK < /em > inhibitors
Conclusion: We describe a rare case of WM transformation to DLCBCL treated with chemoimmunotherapy and BTK inhibition. We analyzed tumor DNA obtained at different anatomic sites and circulating tumor DNA (ctDNA) derived from plasma and ascites specimens, with apparent significant temporal and spatial heterogeneity. The case specifically highlights the clinical value of ctDNA of ascites supernatant from WM patients, which is a more convenient and relatively noninvasive method compared with traditional invasive tissue biopsy.PMID:37151353 | PMC:PMC10154527 | DOI:10.3389/pore.2023.1611070 (Source: Cell Research)
Source: Cell Research - May 8, 2023 Category: Cytology Authors: Jingjing Zhu Xinyu Zhu Fengyang Xie Yi Ding Huina Lu Yan Dong Ping Li Jianfei Fu Aibin Liang Yu Zeng Bing Xiu Source Type: research
Case report: Circulating tumor DNA technology displays temporal and spatial heterogeneity in Waldenstr öm macroglobulinemia during treatment with < em > BTK < /em > inhibitors
Conclusion: We describe a rare case of WM transformation to DLCBCL treated with chemoimmunotherapy and BTK inhibition. We analyzed tumor DNA obtained at different anatomic sites and circulating tumor DNA (ctDNA) derived from plasma and ascites specimens, with apparent significant temporal and spatial heterogeneity. The case specifically highlights the clinical value of ctDNA of ascites supernatant from WM patients, which is a more convenient and relatively noninvasive method compared with traditional invasive tissue biopsy.PMID:37151353 | PMC:PMC10154527 | DOI:10.3389/pore.2023.1611070 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - May 8, 2023 Category: Pathology Authors: Jingjing Zhu Xinyu Zhu Fengyang Xie Yi Ding Huina Lu Yan Dong Ping Li Jianfei Fu Aibin Liang Yu Zeng Bing Xiu Source Type: research
Case report: Circulating tumor DNA technology displays temporal and spatial heterogeneity in Waldenstr öm macroglobulinemia during treatment with < em > BTK < /em > inhibitors
Conclusion: We describe a rare case of WM transformation to DLCBCL treated with chemoimmunotherapy and BTK inhibition. We analyzed tumor DNA obtained at different anatomic sites and circulating tumor DNA (ctDNA) derived from plasma and ascites specimens, with apparent significant temporal and spatial heterogeneity. The case specifically highlights the clinical value of ctDNA of ascites supernatant from WM patients, which is a more convenient and relatively noninvasive method compared with traditional invasive tissue biopsy.PMID:37151353 | PMC:PMC10154527 | DOI:10.3389/pore.2023.1611070 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - May 8, 2023 Category: Pathology Authors: Jingjing Zhu Xinyu Zhu Fengyang Xie Yi Ding Huina Lu Yan Dong Ping Li Jianfei Fu Aibin Liang Yu Zeng Bing Xiu Source Type: research
Case report: Circulating tumor DNA technology displays temporal and spatial heterogeneity in Waldenstr öm macroglobulinemia during treatment with < em > BTK < /em > inhibitors
Conclusion: We describe a rare case of WM transformation to DLCBCL treated with chemoimmunotherapy and BTK inhibition. We analyzed tumor DNA obtained at different anatomic sites and circulating tumor DNA (ctDNA) derived from plasma and ascites specimens, with apparent significant temporal and spatial heterogeneity. The case specifically highlights the clinical value of ctDNA of ascites supernatant from WM patients, which is a more convenient and relatively noninvasive method compared with traditional invasive tissue biopsy.PMID:37151353 | PMC:PMC10154527 | DOI:10.3389/pore.2023.1611070 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - May 8, 2023 Category: Pathology Authors: Jingjing Zhu Xinyu Zhu Fengyang Xie Yi Ding Huina Lu Yan Dong Ping Li Jianfei Fu Aibin Liang Yu Zeng Bing Xiu Source Type: research
Hematology/Oncology Clinics of North America
Waldenstr öm Macroglobulinemia (Source: Hematology/Oncology Clinics of North America)
Source: Hematology/Oncology Clinics of North America - May 6, 2023 Category: Cancer & Oncology Source Type: research
Diagnosing, imaging, and successfully treating a debilitating case of Bing –Neel syndrome: A multidisciplinary feat
We present a case of Bing –Neel syndrome a rare central nervous system lymphoplasmocytic lymphoma associated with Waldenstrom macroglobulinemia. Diagnosis should be considered in the context of unexplained neurological symptoms in the presence of macroglobulinemia.AbstractWaldenstroms macroglobulinaemia (WM) is a rare B-cell lymphoma representing ~2% of all hematological malignancies. While most neurological complications of WM are secondary to the overproduction of immunoglobulin M (IgM), Bing-Neel syndrome (BNS) is an extremely rare direct central nervous system (CNS) infiltration by malignant lymphoplasmocytic lymphom...
Source: Clinical Case Reports - May 5, 2023 Category: General Medicine Authors: Robert N. Kerley,
Niamh O'Donnell,
Fiona Lynott,
Riona Mulcahy,
Brian Hennessy Tags: CASE REPORT Source Type: research
