Case report: Circulating tumor DNA technology displays temporal and spatial heterogeneity in Waldenstr öm macroglobulinemia during treatment with < em > BTK < /em > inhibitors

Conclusion: We describe a rare case of WM transformation to DLCBCL treated with chemoimmunotherapy and BTK inhibition. We analyzed tumor DNA obtained at different anatomic sites and circulating tumor DNA (ctDNA) derived from plasma and ascites specimens, with apparent significant temporal and spatial heterogeneity. The case specifically highlights the clinical value of ctDNA of ascites supernatant from WM patients, which is a more convenient and relatively noninvasive method compared with traditional invasive tissue biopsy.PMID:37151353 | PMC:PMC10154527 | DOI:10.3389/pore.2023.1611070
Source: Cell Research - Category: Cytology Authors: Source Type: research