Assessment of Suvorexant and Eszopiclone as Alternatives to Benzodiazepines for Treating Insomnia in Patients With Major Depressive Disorder
Conclusions
Switching to suvorexant or eszopiclone was well tolerated and improved the severity of benzodiazepine-unresponsive insomnia in MDD patients. Both drugs could be beneficial alternatives to benzodiazepines for treating insomnia in MDD patients. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - May 1, 2022 Category: Neurology Tags: Original Articles Source Type: research
Hypnotic and Melatonin/Melatonin-Receptor Agonist Treatment in Bipolar Disorder: A Systematic Review and Meta-Analysis
ConclusionsThere is a paucity of studies examining pharmacological interventions for sleep and circadian rhythm disturbance in BD. Few studies assessed sleep-related symptoms, and none quantitatively examined endogenous melatonin patterns or other circadian rhythms. Melatonin may be a promising candidate for the adjunctive treatment of bipolar mania. However, dose-finding studies and studies with larger sample sizes are needed to confirm its efficacy. We recommend parallel monitoring of sleep and circadian rhythms in future trials. Chronobiology-informed trial designs are needed to improve the quality of future studies.Pro...
Source: CNS Drugs - March 19, 2022 Category: Neurology Source Type: research
Effects of eszopiclone on sleep quality and cognitive function in elderly patients with Alzheimer's disease and sleep disorder: A randomized controlled trial
ConclusionEszopiclone can effectively improve the quality of sleep and cognitive function in elderly patients with AD and sleep disorder. (Source: Brain and Behavior)
Source: Brain and Behavior - January 18, 2022 Category: Neurology Authors: Shuyu Huo,
Lin Cheng,
Shuying Li,
Fulu Xu Tags: ORIGINAL ARTICLE Source Type: research
Association Between Z Drugs Use and Risk of Cognitive Impairment in Middle-Aged and Older Patients With Chronic Insomnia
Conclusion: BZD exposure density was an independent risk factor of cognitive impairment in middle-aged and older patients with chronic insomnia, but no correlation was found between Z drug use and cognitive impairment. Moreover, the use of Z drugs seemed to be associated with protection for attention. The use for prescription of BZDs, in this case, should be avoided or limited to low doses. Due to the addiction and tolerance, Z drugs should also be prescribed with great caution in middle-aged and elderly patients. (Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - December 9, 2021 Category: Neuroscience Source Type: research
Standardization of Hypnotic Agents for Prevention of Falls: A Pharmacoeconomic Study
In this study, the standardization of insomnia treatment was evaluated by pharmacoeconomics. The costs of the hypnotic agents was considered, as was the cost of examination/treatment following falls. Effectiveness was evaluated as the incidence of falls within 24 hours of taking hypnotic agents. This analysis took the public healthcare payer's perspective. Propensity score matching based on patient background, showed that, per hospitalization the medicine costs of the recommended group increased by 1,020 yen, however, the examination/treatment costs following falls decreased by 487 yen when compared with the non-recommende...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 1, 2021 Category: Drugs & Pharmacology Authors: Atsuyuki Saisyo Miwako Takasago Kazuki Wakabayashi Mari Akiyama Kyoji Kouda Akihisa Takasaki Kazuto Matsunaga Haku Ishida Takashi Kitahara Source Type: research
Standardization of Hypnotic Agents for Prevention of Falls: A Pharmacoeconomic Study
In this study, the standardization of insomnia treatment was evaluated by pharmacoeconomics. The costs of the hypnotic agents was considered, as was the cost of examination/treatment following falls. Effectiveness was evaluated as the incidence of falls within 24 hours of taking hypnotic agents. This analysis took the public healthcare payer's perspective. Propensity score matching based on patient background, showed that, per hospitalization the medicine costs of the recommended group increased by 1,020 yen, however, the examination/treatment costs following falls decreased by 487 yen when compared with the non-recommende...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 1, 2021 Category: Drugs & Pharmacology Authors: Atsuyuki Saisyo Miwako Takasago Kazuki Wakabayashi Mari Akiyama Kyoji Kouda Akihisa Takasaki Kazuto Matsunaga Haku Ishida Takashi Kitahara Source Type: research
Standardization of Hypnotic Agents for Prevention of Falls: A Pharmacoeconomic Study
In this study, the standardization of insomnia treatment was evaluated by pharmacoeconomics. The costs of the hypnotic agents was considered, as was the cost of examination/treatment following falls. Effectiveness was evaluated as the incidence of falls within 24 hours of taking hypnotic agents. This analysis took the public healthcare payer's perspective. Propensity score matching based on patient background, showed that, per hospitalization the medicine costs of the recommended group increased by 1,020 yen, however, the examination/treatment costs following falls decreased by 487 yen when compared with the non-recommende...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 1, 2021 Category: Drugs & Pharmacology Authors: Atsuyuki Saisyo Miwako Takasago Kazuki Wakabayashi Mari Akiyama Kyoji Kouda Akihisa Takasaki Kazuto Matsunaga Haku Ishida Takashi Kitahara Source Type: research
Standardization of Hypnotic Agents for Prevention of Falls: A Pharmacoeconomic Study
In this study, the standardization of insomnia treatment was evaluated by pharmacoeconomics. The costs of the hypnotic agents was considered, as was the cost of examination/treatment following falls. Effectiveness was evaluated as the incidence of falls within 24 hours of taking hypnotic agents. This analysis took the public healthcare payer's perspective. Propensity score matching based on patient background, showed that, per hospitalization the medicine costs of the recommended group increased by 1,020 yen, however, the examination/treatment costs following falls decreased by 487 yen when compared with the non-recommende...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 1, 2021 Category: Drugs & Pharmacology Authors: Atsuyuki Saisyo Miwako Takasago Kazuki Wakabayashi Mari Akiyama Kyoji Kouda Akihisa Takasaki Kazuto Matsunaga Haku Ishida Takashi Kitahara Source Type: research
Standardization of Hypnotic Agents for Prevention of Falls: A Pharmacoeconomic Study
In this study, the standardization of insomnia treatment was evaluated by pharmacoeconomics. The costs of the hypnotic agents was considered, as was the cost of examination/treatment following falls. Effectiveness was evaluated as the incidence of falls within 24 hours of taking hypnotic agents. This analysis took the public healthcare payer's perspective. Propensity score matching based on patient background, showed that, per hospitalization the medicine costs of the recommended group increased by 1,020 yen, however, the examination/treatment costs following falls decreased by 487 yen when compared with the non-recommende...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 1, 2021 Category: Drugs & Pharmacology Authors: Atsuyuki Saisyo Miwako Takasago Kazuki Wakabayashi Mari Akiyama Kyoji Kouda Akihisa Takasaki Kazuto Matsunaga Haku Ishida Takashi Kitahara Source Type: research
Standardization of Hypnotic Agents for Prevention of Falls: A Pharmacoeconomic Study
In this study, the standardization of insomnia treatment was evaluated by pharmacoeconomics. The costs of the hypnotic agents was considered, as was the cost of examination/treatment following falls. Effectiveness was evaluated as the incidence of falls within 24 hours of taking hypnotic agents. This analysis took the public healthcare payer's perspective. Propensity score matching based on patient background, showed that, per hospitalization the medicine costs of the recommended group increased by 1,020 yen, however, the examination/treatment costs following falls decreased by 487 yen when compared with the non-recommende...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 1, 2021 Category: Drugs & Pharmacology Authors: Atsuyuki Saisyo Miwako Takasago Kazuki Wakabayashi Mari Akiyama Kyoji Kouda Akihisa Takasaki Kazuto Matsunaga Haku Ishida Takashi Kitahara Source Type: research
Standardization of Hypnotic Agents for Prevention of Falls: A Pharmacoeconomic Study
In this study, the standardization of insomnia treatment was evaluated by pharmacoeconomics. The costs of the hypnotic agents was considered, as was the cost of examination/treatment following falls. Effectiveness was evaluated as the incidence of falls within 24 hours of taking hypnotic agents. This analysis took the public healthcare payer's perspective. Propensity score matching based on patient background, showed that, per hospitalization the medicine costs of the recommended group increased by 1,020 yen, however, the examination/treatment costs following falls decreased by 487 yen when compared with the non-recommende...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 1, 2021 Category: Drugs & Pharmacology Authors: Atsuyuki Saisyo Miwako Takasago Kazuki Wakabayashi Mari Akiyama Kyoji Kouda Akihisa Takasaki Kazuto Matsunaga Haku Ishida Takashi Kitahara Source Type: research
Standardization of Hypnotic Agents for Prevention of Falls: A Pharmacoeconomic Study
In this study, the standardization of insomnia treatment was evaluated by pharmacoeconomics. The costs of the hypnotic agents was considered, as was the cost of examination/treatment following falls. Effectiveness was evaluated as the incidence of falls within 24 hours of taking hypnotic agents. This analysis took the public healthcare payer's perspective. Propensity score matching based on patient background, showed that, per hospitalization the medicine costs of the recommended group increased by 1,020 yen, however, the examination/treatment costs following falls decreased by 487 yen when compared with the non-recommende...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 1, 2021 Category: Drugs & Pharmacology Authors: Atsuyuki Saisyo Miwako Takasago Kazuki Wakabayashi Mari Akiyama Kyoji Kouda Akihisa Takasaki Kazuto Matsunaga Haku Ishida Takashi Kitahara Source Type: research
Standardization of Hypnotic Agents for Prevention of Falls: A Pharmacoeconomic Study
In this study, the standardization of insomnia treatment was evaluated by pharmacoeconomics. The costs of the hypnotic agents was considered, as was the cost of examination/treatment following falls. Effectiveness was evaluated as the incidence of falls within 24 hours of taking hypnotic agents. This analysis took the public healthcare payer's perspective. Propensity score matching based on patient background, showed that, per hospitalization the medicine costs of the recommended group increased by 1,020 yen, however, the examination/treatment costs following falls decreased by 487 yen when compared with the non-recommende...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 1, 2021 Category: Drugs & Pharmacology Authors: Atsuyuki Saisyo Miwako Takasago Kazuki Wakabayashi Mari Akiyama Kyoji Kouda Akihisa Takasaki Kazuto Matsunaga Haku Ishida Takashi Kitahara Source Type: research
