Polar lipids modify Alzheimer ’s Disease pathology by reducing astrocyte pro-inflammatory signaling through platelet-activating factor receptor (PTAFR) modulation
Pro-inflammatory processes triggered by the accumulation of extracellular amyloid beta (A β) peptides are a well-described pathology in Alzheimer's disease (AD). Activated astrocytes surrounding Aβ plaques cont... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 20, 2024 Category: Lipidology Authors: Sakshi Hans, Janelle E. Stanton, Ann Katrin Sauer, Katie Shiels, Sushanta Kumar Saha, Ronan Lordan, Alexandros Tsoupras, Ioannis Zabetakis and Andreas M. Grabrucker Tags: Research Source Type: research
Can essential fatty acids (EFAs) prevent and ameliorate post-COVID-19 long haul manifestations?
It is hypothesized that COVID-19, post-COVID and post-mRNA COVID-19 (and other related) vaccine manifestations including “long haul syndrome” are due to deficiency of essential fatty acids (EFAs) and dysregula... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 19, 2024 Category: Lipidology Authors: Undurti N. Das Tags: Review Source Type: research
Discrimination and net-reclassification of cardiovascular disease risk with Lipoprotein(a) levels: the ATTICA study (2002-2022)
Numerous studies have confirmed that lipoproteins containing apolipoprotein B (apoB), such as low-density lipoproteins (LDL), very low-density lipoproteins (VLDL) and their remnants, intermediate density lipoproteins (IDL), and lipoprotein(a) (Lp(a)), play a direct role in the onset of atherosclerotic cardiovascular disease (ASCVD).1 Lp(a), a molecule that is similar to low-density lipoprotein cholesterol (LDL-C), has been identified as a risk factor for ASCVD via induction of inflammation, atherogenesis, and thrombosis. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - April 18, 2024 Category: Lipidology Authors: Sofia-Panagiota Giannakopoulou, Christina Chrysohoou, Smaragdi Antonopoulou, Evangelia Damigou, Fotios Barkas, Christina Vafia, Evrydiki Kravvariti, Costas Tsioufis, Christos Pitsavos, Evangelos Liberopoulos, Petros P. Sfikakis, Demosthenes Panagiotakos Tags: Original Research Source Type: research
Identification and validation of biomarkers related to lipid metabolism in osteoarthritis based on machine learning algorithms
Osteoarthritis and lipid metabolism are strongly associated, although the precise targets and regulatory mechanisms are unknown. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 18, 2024 Category: Lipidology Authors: Hang Li, Yubao Cui, Jian Wang, Wei Zhang, Yuhao Chen and Jijun Zhao Tags: Research Source Type: research
Cascade Screening for Familial Hypercholesterolemia from Pediatric Index Cases Diagnosed Through Universal Screening
Heterozygous Familial Hypercholesterolemia (HeFH) is an autosomal dominant genetic disorder that affects approximately 1 in 300 people1, 2 worldwide, making it the most common life-threatening inherited metabolic condition. It is characterized by lifelong abnormally high levels of low-density lipoprotein cholesterol (LDL-C) that cause atherosclerotic cardiovascular disease (ASCVD) and premature cardiovascular disease events, including myocardial infarction and stroke3. Without treatment, patients with HeFH often develop ASCVD events before age 604. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - April 18, 2024 Category: Lipidology Authors: Morgan Lentz, Megan Benoy, Xiao Zhang, Amy L. Peterson Tags: Brief Communication Source Type: research
Blood lipids mediate the effects of gut microbiome on endometriosis: a mendelian randomization study
There is evidence for an association between the gut microbiome and endometriosis. However, their causal relationship and the mediating role of lipid metabolism remain unclear. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 16, 2024 Category: Lipidology Authors: Chang Su, Su Wan, Jin Ding, Guantai Ni and Huafeng Ding Tags: Research Source Type: research
The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
The impact of phospholipids with high transition temperature to enhance Redox-Sensitive liposomal doxorubicin efficacy in colon carcinoma model
In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation by incorporating 10,10'-diselanediylbis decanoic acid (DDA) organoselenium compound as the RS moiety. Hence, several RS liposomal formulations were prepared by using DOPE, HSPC, DDA, mPEG2000-DSPE, and cholesterol. In situ drug loading using a pH gradient and citrate complex yielded high drug to lipid ratio and encapsulation efficiency (100%) for RS liposomes. Liposomal formulations were characterized in terms of size, surface charge and morphology, drug loading, release properties, cell uptake and cytotoxicity, as well as therapeutic...
Source: Chemistry and Physics of Lipids - April 15, 2024 Category: Lipidology Authors: Elaheh Mirhadi Anis Askarizadeh Leila Farhoudi Mohammad Mashreghi Saeed Behboodifar Seyedeh Hoda Alavizadeh Leila Arabi Mahmoud Reza Jaafari Source Type: research
The impact of lipidome on breast cancer: a Mendelian randomization study
This study aims to investigate the association between specific lipidomes and the risk of breast cancer (BC) using the Two-Sample Mendelian Randomization (TSMR) approach and Bayesian Model Averaging Mendelian ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 15, 2024 Category: Lipidology Authors: Yuchen Cao, Meichen Ai and Chunjun Liu Tags: Research Source Type: research
Effect of oesophagectomy on lipid profiles in patients with oesophageal cancer combined with hyperlipidaemia: a retrospective study
Surgery is widely regarded as a pivotal therapeutic approach for treating oesophageal cancer, and clinical observations have revealed that many oesophageal cancer patients also present with concomitant hyperli... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 15, 2024 Category: Lipidology Authors: Jingrong Yang, Yaxin Li, Jialei Huang, Jiabin Lai, Xiangrui Chen, Wenxuan Xia and Yu Wang Tags: Research Source Type: research
Triglyceride-glucose index predicts postoperative delirium in elderly patients with type 2 diabetes mellitus: a retrospective cohort study
Postoperative delirium (POD) is more prevalent among elderly patients with type 2 diabetes mellitus (T2DM). Insulin resistance (IR) can be assessed using the triglyceride-glucose (TyG) index, a novel biomarker... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 15, 2024 Category: Lipidology Authors: Miao Sun, Min Liu, Faqiang Zhang, Lijuan Sang, Yuxiang Song, Peng Li, Siyuan Liu, Huikai Yang, Libin Ma, Jiangbei Cao, Weidong Mi and Yulong Ma Tags: Research Source Type: research
Unfavorably altered lipid profile in women with primary ovarian insufficiency.
Premature ovarian insufficiency (POI) is defined as the cessation of ovarian function before the age of 40 along with elevated levels of follicle-stimulating hormone (FSH)>25 IU/L1. POI is diagnosed among 1-2% of women worldwide and may be caused by chromosomal and genetic defects, autoimmune processes, chemotherapy, radiation, infections and surgery, however, majority of cases remain unidentified2. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - April 15, 2024 Category: Lipidology Authors: Pir óg Magdalena, Kacalska-Janssen Olga, Pulka Anna, Jach Robert Tags: Original Research Source Type: research
