Uric acid, high density lipoprotein cholesterol levels and their ratio are related to microbial enterotypes and serum metabolites in females with a blood stasis constitution
Blood stasis constitution in traditional Chinese medicine (TCM) is believed to render individuals more susceptible to metabolic diseases. However, the biological underpinnings of this constitutional imbalance ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 27, 2024 Category: Lipidology Authors: Chen Sun, Yanmin Liu, Wei Huang, Yang Chen, Yusheng Deng, Jiamin Yuan, Lili Deng, Ning Xu, Xiaoxiao Shang, Chuyang Wang, Zhimin Yang, Li Huang and Qinwei Qiu Tags: Research Source Type: research

The serum soluble ASGR1 concentration is elevated in patients with coronary artery disease and is associated with inflammatory markers
This study aimed to assess the correlation between ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 27, 2024 Category: Lipidology Authors: Qin Luo, Jingfei Chen, Yanfeng Yi, Panyun Wu, Yingjie Su, Zhangling Chen, Hac ı Ahmet Aydemir, Jianjun Tang, Zhenfei Fang and Fei Luo Tags: Research Source Type: research

Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism
The accumulation of reactive oxygen species (ROS) within the bone marrow microenvironment leads to diminished osteogenic differentiation and heightened lipogenic differentiation of mesenchymal stem cells resid... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 25, 2024 Category: Lipidology Authors: Jinying Li, Yongshao Chen, Dingsheng Zha, Chunhui Wu, Xiaofen Li, Li Yang, Hui Cao, Shexing Cai and Yuebo Cai Tags: Research Source Type: research

Triglyceride-glucose index in early pregnancy predicts the risk of gestational diabetes: a prospective cohort study
This study aimed to investigate the association between the triglyceride-glucose (TyG) index in early pregnancy and the development of gestational diabetes mellitus (GDM) in the second trimester. The primary o... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 25, 2024 Category: Lipidology Authors: Yufeng Guo, Junwen Lu, Mailiman Bahani, Guifeng Ding, Lei Wang, Yuxia Zhang, Huanmei Zhang, Chengyao Liu, Lijun Zhou, Xiaolan Liu, Fangshen Li, Xiaoli Wang and Hong Ding Tags: Research Source Type: research

Fibrinogen to HDL-Cholesterol ratio as a predictor of mortality risk in patients with acute myocardial infarction
Acute myocardial infarction (AMI) is characterized by inflammation, oxidative stress, and atherosclerosis, contributing to increased mortality risk. High-density lipoprotein (HDL) takes a crucial part in mitig... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 25, 2024 Category: Lipidology Authors: Congzhuo Jia, Wanying Wu, Huan Lu, Jin Liu, Shiqun Chen, Guoxiao Liang, Yang Zhou, Sijia Yu, Linfang Qiao, Jinming Chen, Ning Tan, Yong Liu and Jiyan Chen Tags: Research Source Type: research

LDLR c.415G   >  A causes familial hypercholesterolemia by weakening LDLR binding to LDL
In this study, we confirmed that c.415G  > A in low-density lipoprotein receptor (LDLR), an FH-r... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 21, 2024 Category: Lipidology Authors: Kaihan Wang, Tingting Hu, Mengmeng Tai, Yan Shen, Haocheng Chai, Shaoyi Lin and Xiaomin Chen Tags: Research Source Type: research

SGLT2 inhibition, high-density lipoprotein, and kidney function: a mendelian randomization study
Sodium-glucose cotransporter 2 (SGLT2) inhibition is recognized for its evident renoprotective benefits in diabetic renal disease. Recent data suggest that SGLT2 inhibition also slows down kidney disease progr... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 20, 2024 Category: Lipidology Authors: Zhijuan Wang, Jie Wei, Wenman Zhao, Rui Shi, Yuyu Zhu, Xunliang Li and Deguang Wang Tags: Research Source Type: research

Gene variants and clinical characteristics of children with sitosterolemia
To enhance the detection, management and monitoring of Chinese children afflicted with sitosterolemia by examining the physical characteristics and genetic makeup of pediatric patients. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 20, 2024 Category: Lipidology Authors: Rui Gu, Hui Wang, Chun-Lin Wang, Mei Lu, Miao Miao, Meng-Na Huang, Yi Chen, Yang-Li Dai, Ming-Qiang Zhu, Qiong Zhou and Chao-Chun Zou Tags: Research Source Type: research

Association between dietary magnesium intake and gallstones: the mediating role of atherogenic index of plasma
Dyslipidemia and abnormalities in cholesterol metabolism are commonly observed in individuals with gallstone disease. Previous research has demonstrated that dietary magnesium can influence lipid metabolism. T... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 20, 2024 Category: Lipidology Authors: Wenyi Du, Chen Yan, Yinkang Wang, Chen Song, Yunfan Li, Zhiqiang Tian, Yuan Liu and Wei Shen Tags: Research Source Type: research

PDGFR β + cell HIF2α is dispensable for white adipose tissue metabolic remodeling and hepatic lipid accumulation in obese mice
Obesity is associated with extensive white adipose tissue (WAT) expansion and remodeling. Healthy WAT expansion contributes to the maintenance of energy balance in the liver, thereby ameliorating obesity-relat... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 20, 2024 Category: Lipidology Authors: Tao Yao, Danni Wei, Xin Tian, Lin Zhao, Qiangyou Wan, Xiaoli Zhang, Juan Cai, Siqi Li, Bowen Diao, Suihan Feng, Bo Shan, Mengle Shao and Ying Wu Tags: Brief Report Source Type: research

Nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with Moyamoya disease: a prospective cohort study
The study aimed to investigate the association between nonalcoholic fatty liver disease (NAFLD) and ischemic stroke events after revascularization in patients with Moyamoya disease (MMD). (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 17, 2024 Category: Lipidology Authors: Bojian Zhang, Junsheng Li, Chaofan Zeng, Chuming Tao, Qiheng He, Chenglong Liu, Zhiyao Zheng, Zhikang Zhao, Siqi Mou, Wei Sun, Jia Wang, Qian Zhang, Rong Wang, Yan Zhang, Peicong Ge and Dong Zhang Tags: Research Source Type: research

Genetically and Clinically Confirmed Atypical Cerebrotendinous Xanthomatosis with Normal Cholestanol and Marked Elevations of Bile Acid Precursors and Bile Alcohols
Cerebrotendinous xanthomatosis (CTX, OMIM 213700) is a rare autosomal recessive disorder associated with deficiency of the CYP27A1 enzyme (sterol 27-hydroxylase), encoded by the CYP27A1 gene1, 2. The presentation of clinical features in CTX is complex, with heterogeneous symptoms, variable severity and evolution of complications, and diverse differences in progression of disease even within the same family1, 2. In a series of 43 cases in the United States, the mean age at diagnosis was 32 years3. In these patients, 53% experienced chronic diarrhea in childhood, 74% had cognitive impairment in childhood adolescence, 70% wer...
Source: Journal of Clinical Lipidology - March 15, 2024 Category: Lipidology Authors: Andrea E DeBarber, Ernst J. Schaefer, Jenny Do, Joseph W Ray, Austin Larson, Samantha Redder, Maya Fowler, P Barton Duell Tags: Original Research Source Type: research

Longitudinal analysis of clinical and laboratory biomarkers in a patient with Familial Lecithin: Cholesterol acyltransferase deficiency (FLD) and accelerated eGFR decline: a case study.
Familial LCAT Deficiency (FLD) is an ultra-rare autosomal recessive disorder caused by complete loss of function variants in the gene encoding for lecithin:cholesterol acyltransferase (LCAT).1FLD is characterized by very low HDL-Cholesterol (HDL-C) levels, often reduced LDL-Cholesterol (LDL-C) levels, elevated and variable triglycerides (TG), and the presence of abnormal lipoproteins such as lipoprotein X (LpX), which is believed to be nephrotoxic.1 Despite having significantly reduced HDL-C levels, FLD patients are not higher risk of atherosclerotic cardiovascular disease. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - March 13, 2024 Category: Lipidology Authors: Gregory Alfaro, Jay Pendyala, Michael Sulewski, Michael Miller, Cecilia Vitali, Marina Cuchel Tags: Case Study Source Type: research

Triglyceride-glucose index in the prediction of new-onset arthritis in the general population aged over 45: the first longitudinal evidence from CHARLS
Insulin resistance (IR) imposes a significant burden on inflammatory diseases, and the triglyceride-glucose (TyG) index, which is an easily accessible indicator for detecting IR, holds great application potent... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 13, 2024 Category: Lipidology Authors: Yang Liu, Junjie Yao, Xiaona Xue, Yanan Lv, Sheng Guo and PeiDong Wei Tags: Research Source Type: research

Effect of Statin Use on Liver Enzymes and Lipid Profile in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with the prevalence of approximately 30%.1 The prevalence goes up among specific high-risk populations: 30-50% in patients with type 2 diabetes, and 80-90% in patients with obesity.2,3 (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - March 12, 2024 Category: Lipidology Authors: Anh Ho, Takako Kiener, Quynh-Nhu Nguyen, Quang A. Le Tags: Original Research Source Type: research