Malar rash and hand tremor in early symptoms of cerebrotendinous xanthomatosis and the effect of chenodeoxycholic acid on them
Cerebrotendinous xanthomatosis (CTX, OMIM #213700) is a rare, autosomal recessive, neurodegenerative lipid storage disease with multisystemic involvement.1 The incidence of CTX is estimated to be between 1/72000-1/150000, and prevalence is 3/100000-5/100000.2 CTX disease occurs due to mutations in the CYP27A1 gene on chromosome 2, which causes defects in synthesizing the sterol 27-hydroxylase enzyme that plays a role in mitochondrial cholesterol metabolism and bile acid synthesis.1,3 This enzyme deficiency causes a decrease in the production of cholic acid and chenodeoxycholic acid and an increase in the production of chol...
Source: Journal of Clinical Lipidology - February 28, 2024 Category: Lipidology Authors: Banu Kad ıoğlu Yılmaz, Halil Çelik Tags: Original Research Source Type: research
Effect of sacubitril/valsartan on lipid metabolism in patients with chronic kidney disease combined with chronic heart failure: a retrospective study
Dyslipidemia is significantly more common in those with concurrent chronic kidney disease (CKD) and chronic heart failure (CHF). Sacubitril/valsartan has showcased its influence on both cardiac and renal funct... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 28, 2024 Category: Lipidology Authors: Manzhi Li, Ao Zhong, Yifan Tang, Jinnuo Yu, Mengmeng Wu, Karthick Kumaran Munisamy Selvam and Dong Sun Tags: Research Source Type: research
In-hospital and mid-term follow-up of low-density lipoprotein cholesterol and target-goal attainment among patients with acute cerebral infarction: a retrospective study
To investigate the baseline and six-month follow-up data of the main lipid indices as well as low-density lipoprotein cholesterol (LDL-C) target goal attainment in accordance with the current guidelines among ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 28, 2024 Category: Lipidology Authors: Zhong Chen, Shijia Jin and Yifan Zhang Tags: Research Source Type: research
Appraising associations between signature lipidomic biomarkers and digestive system cancer risk: novel evidences from a prospective cohort study of UK Biobank and Mendelian randomization analyses
In this study, we systematically assessed indicative effects of signature lipidomic biomarkers (high-density lipoprotein... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 28, 2024 Category: Lipidology Authors: Yuanlin Sun, Donghui Cao, Yang Zhang, Yanhua Wu, Zhifang Jia, Yingnan Cui, Dongming Li, Xueyuan Cao and Jing Jiang Tags: Research Source Type: research
Correction: The association between triglyceride glucose index and arthritis: a population-based study
(Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 27, 2024 Category: Lipidology Authors: Yuxin Yan, Liyu Zhou, Rui La, Ming Jiang, Dinghua Jiang, Lixin Huang, Wu Xu and Qian Wu Tags: Correction Source Type: research
Pre-operative levels of angiopoietin protein-like 3 (ANGPTL3) in women diagnosed with high-grade serous carcinoma of the ovary
Cancer cells need constant supplies of lipids to survive and grow. Lipid dependence has been observed in various types of cancer, including high-grade serous ovarian carcinomas (HGSOC), which is a lethal form ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 27, 2024 Category: Lipidology Authors: Emilie Wong Chong, France-H élène Joncas, Pierre Douville, Dimcho Bachvarov, Caroline Diorio, Frédéric Calon, Ann-Charlotte Bergeron, Jonatan Blais, Shuk On Annie Leung, Nabil Georges Seidah and Anne Gangloff Tags: Research Source Type: research
Bidirectional two-sample mendelian randomization analysis identifies causal associations of MRI-based cortical thickness and surface area relation to NAFLD
This study investigates the causal effect of NAFLD on cortica... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 23, 2024 Category: Lipidology Authors: Zun Mao, Zhi-xiang Gao, Tong Ji, Sheng Huan, Guo-ping Yin and Long Chen Tags: Research Source Type: research
Pancreatitis polygenic risk score is associated with acute pancreatitis in multifactorial chylomicronemia syndrome
Severe hypertriglyceridemia (hyperTG) is defined clinically as fasting triglycerides (TG) levels ≥ 10 mmol/L1. Severe hyperTG is often caused by the accumulation of chylomicrons in the circulation, a condition known as chylomicronemia syndrome1. Chylomicronemia syndrome is a relatively common metabolic condition in North America population, with an estimated prevalence around 1:10002-7. Howev er, it is likely underreported, and the prevalence will probably increase in context of the current epidemy of obesity and type 2 diabetes1, 4. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - February 22, 2024 Category: Lipidology Authors: Simon-Pierre Guay, Martine Paquette, Am élie Taschereau, Véronique Desgagné, Luigi Bouchard, Sophie Bernard, Alexis Baass Tags: Original Research Source Type: research
Identification of risk factors and development of a predictive model for chronic kidney disease in patients with obesity: a four-year cohort study
The sneaky onset and dismal prognosis of chronic kidney disease (CKD) make it an important public health issue. Obesity-related kidney illness has garnered more attention in recent times. Establishing and vali... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 22, 2024 Category: Lipidology Authors: Haixia Zhang, Yue Zhang, Wenxing Gao and Yiming Mu Tags: Research Source Type: research
HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults
This study aimed to examine both clinical and genetic factors of T2D in older a... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 22, 2024 Category: Lipidology Authors: Siobh án O.’ Sullivan, Cynthia Al Hageh, Andreas Henschel, Stephanie Chacar, Antoine Abchee, Pierre Zalloua and Moni Nader Tags: Brief Report Source Type: research
Sexual dysfunction in patients with diabetes: association between remnant cholesterol and erectile dysfunction
Erectile dysfunction (ED) is closely associated with dyslipidemia; however, it is yet unknown how ED and remnant cholesterol (RC) are related. As such, this research sought to explore the correlation between R... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 22, 2024 Category: Lipidology Authors: Ke Huang, Shan Yin, Yunfei Xiao, Jiahao Wang, Jianwei Cui, Jia Wang and Yunjin Bai Tags: Research Source Type: research
Establishing non-fasting reference values for plasma lipids levels based on age, sex, and puberty stage in a French-Canadian pediatric population
Dyslipidemias, including familial hypercholesterolemia (FH), are a significant risk factor for cardiovascular diseases. FH is a genetic disorder resulting in elevated levels of low-density lipoprotein choleste... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 22, 2024 Category: Lipidology Authors: Sophie Bouhour, Rosalie Plantef ève, Virginie Gillet, Armita Abolghasemi, Fatima Zahra Bouchouirab, Andrea A. Baccarelli, Larissa Takser and Artuela Çaku Tags: Research Source Type: research
Association of triglyceride glucose-body mass index and hemoglobin glycation index with heart failure prevalence in hypertensive populations: a study across different glucose metabolism status
The Triglyceride glucose-body mass index (TyG-BMI) and hemoglobin glycation index (HGI) are well-established surrogate markers for insulin resistance. Nevertheless, the extent to which these markers offer addi... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 22, 2024 Category: Lipidology Authors: Rupeng Wang, Ce Chen, Guiyu Xu and Zening Jin Tags: Research Source Type: research
Statins Use for Primary Prevention of Cardiovascular Disease: A Population-based Digitally Enabled Real-world Evidence Cross-Sectional Study in Primary Care in Brazil
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality worldwide and especially in low and middle-income countries (LMICs).1 Statins represent a key strategy to prevent dyslipidemia-associated CVD morbidity and mortality, because of their reduction on LDL-cholesterol (LDL-C) concentrations, as well as anti-inflammatory and other plaque-stabilization effects.2-4 Although individuals without previous CVD are at lower absolute risk, at least half of all vascular events occur among them. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - February 20, 2024 Category: Lipidology Authors: Karla Santo, Raul D. Santos, Alysson Nathan Girotto, Josue Nieri, Frederico Monfardini, Priscila Raupp, Pedro Marton Pereira, Otavio Berwanger, M. Julia Machline-Carrion Tags: Original Research Source Type: research
Topical rhubarb charcoal-crosslinked chitosan/silk fibroin sponge scaffold for the repair of diabetic ulcers improves hepatic lipid deposition in db/db mice via the AMPK signalling pathway
Type 2 diabetes mellitus (T2DM) is closely linked to metabolic syndrome, characterised by insulin resistance, hyperglycaemia, abnormal lipid metabolism, and chronic inflammation. Diabetic ulcers (DUs) comprise... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - February 20, 2024 Category: Lipidology Authors: Qi Tan, Qifeng He, Ze Peng, Xin Zeng, Yuzhe Liu, Dong Li, Shang Wang and Jianwei Wang Tags: Research Source Type: research
