Association of birth weight with type 2 diabetes mellitus and the mediating role of fatty acids traits: a two-step mendelian randomization study
Observational studies have suggested an association between birth weight and type 2 diabetes mellitus, but the causality between them has not been established. We aimed to obtain the causal relationship betwee... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 2, 2024 Category: Lipidology Authors: Limin Cao, Yahui Wen, Keyi Fan, Qiwei Wang, Yaochen Zhang, Zhenglong Li, Nan Wang and Xinhua Zhang Tags: Research Source Type: research
Triglyceride to high-density lipoprotein cholesterol ratio associated with long-term adverse clinical outcomes in patients deferred revascularization following fractional flow reserve
Guidelines on coronary intermediate lesions strongly recommend deferred revascularization after detecting a normal fractional flow reserve (FFR). Researches about triglyceride to high-density lipoprotein chole... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 2, 2024 Category: Lipidology Authors: Fanqi Li, Xiaofang Li, Jiabao Zhou, Qiuzhen Lin, Yong Zhou, Jiayi Zhu, Keke Wu, Donghui Zhao, Qiuyu Li, Haixiong Wang and Qiming Liu Tags: Research Source Type: research
Advances in management of metabolic dysfunction-associated steatotic liver disease: from mechanisms to therapeutics
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease that affects over 30% of the world ’s population. For decades, the heterogeneity of non-alcoholic f... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 2, 2024 Category: Lipidology Authors: Yuxiao Jiang, Lili Wu, Xiaopeng Zhu, Hua Bian, Xin Gao and Mingfeng Xia Tags: Review Source Type: research
GLUT4 localisation with the plasma membrane is unaffected by an increase in plasma free fatty acid availability
Insulin-stimulated glucose uptake into skeletal muscle occurs via translocation of GLUT4 from intracellular storage vesicles to the plasma membrane. Elevated free fatty acid (FFA) availability via a lipid infu... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 2, 2024 Category: Lipidology Authors: J. S. Barrett, J. A. Strauss, L. S. Chow, S. O. Shepherd, A. J. M. Wagenmakers and Y. Wang Tags: Research Source Type: research
Application of implementation science for improving the utilization of an international clinical practice guidance on familial hypercholesterolemia
Implementation science evolved into a field of research to accelerate the translation of evidence into practice (1,2). While major advances have been made to reduce the time for evidence to be translated into practice, there has been less progress on improving the uptake of clinical practice guidelines. Several guidelines (3-12) and position statements (13-15) in cardiovascular disease have recommended that implementation science approaches be used to address gaps in care. More recently, models have been developed for guideline contributors to embed implementation recommendations into the guideline development and translat...
Source: Journal of Clinical Lipidology - April 1, 2024 Category: Lipidology Authors: Laney K. Jones, Samuel S. Gidding, Raul D. Santos, Peter Libby, Gerald F. Watts, Mitchell N. Sarkies Tags: Original Research Source Type: research
A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice
The lipoprotein(a) [Lp(a)] field is rapidly evolving on many fronts, warranting this focused update to the 2019 National Lipid Association (NLA) Scientific Statement on Use of Lipoprotein(a) in Clinical Practice.1 Recent evidence has influenced our understanding of whom should have Lp(a) levels measured, how to interpret Lp(a) levels for use in risk assessment, and clinical management of patients with elevated Lp(a). The NLA now recommends: (1) measurement of Lp(a) levels at least once in every adult; (2) classification of individuals with Lp(a) levels (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - April 1, 2024 Category: Lipidology Authors: Marlys L. Koschinsky, Archna Bajaj, Michael B. Boffa, Dave L. Dixon, Keith C. Ferdinand, Samuel S. Gidding, Edward A. Gill, Terry A. Jacobson, Erin D. Michos, Maya S. Safarova, Daniel E. Soffer, Pam R. Taub, Michael J. Wilkinson, Don P. Wilson, Christie M Source Type: research
Circulating ceramide levels and ratios in Emirati youth under 18 years: associations with cardiometabolic risk factors
Circulating ceramide (Cer) drives various pathological processes associated with cardiovascular diseases, liver illness, and diabetes mellitus. Although recognized as predictors of cardiometabolic diseases (CM... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 1, 2024 Category: Lipidology Authors: Youssef M. Shalaby, Bashar Al-Zohily, Anjana Raj, Javed Yasin, Sania Al Hamad, Charalambos Antoniades, Nadia Akawi and Elhadi H. Aburawi Tags: Research Source Type: research
Significant but partial lipoprotein lipase functional loss caused by a novel occurrence of rare LPL biallelic variants
Lipoprotein lipase (LPL) plays a crucial role in triglyceride hydrolysis. Rare biallelic variants in the LPL gene leading to complete or near-complete loss of function cause autosomal recessive familial chylomicr... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 1, 2024 Category: Lipidology Authors: Yuepeng Hu, Jian-Min Chen, Han Zuo, Na Pu, Guofu Zhang, Yichen Duan, Gang Li, Zhihui Tong, Weiqin Li, Baiqiang Li and Qi Yang Tags: Research Source Type: research
Detecting Familial Hypercholesterolemia: An Observational Study Leveraging Mandatory Universal Pediatric Total Cholesterol Screening in Slovakia
Familial hypercholesterolemia (FH) is an autosomal-dominant inherited disorder that is often underdiagnosed and undertreated. FH is characterized by a lifelong exposure to high levels of low-density lipoprotein cholesterol (LDL-C), which causes early and accelerated atherogenesis. Patients with genetically defined FH have a risk of coronary heart disease that is>10-fold than that of the general population, and a 3-fold increased risk of cardiovascular disease at the same LDL-C level.1 The relative cardiovascular risk patients with FH is highest between the ages of 25 and 40 years. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - March 29, 2024 Category: Lipidology Authors: Katarina Raslova, Viera Donicova, Katarina Gonova, Alexander Klabnik, Lukas Tichy, Ian Bridges, Dagmar Buckova, Marie Zachlederova, Tomas Freiberger, Branislav Vohnout Tags: Original Research Source Type: research
The role of genetically-influenced phospholipid transfer protein activity in lipoprotein metabolism and coronary artery disease
The phospholipid transfer protein (PLTP) facilitates the transfer of surface phospholipids between lipoprotein particles. For example, during the lipolytic conversion of triglyceride-rich lipoproteins (TRLs), PLTP transfers excess phospholipids to high-density lipoprotein (HDL), allowing TRL remnants to reduce in size (1-3). As such, PLTP plays an important role in the metabolism of both TRLs and HDL, and affects their particle size and composition. Evidence regarding the association of PLTP activity with coronary artery disease (CAD) is inconsistent. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - March 29, 2024 Category: Lipidology Authors: Linjun Ao, Raymond Noordam, Patrick C.N. Rensen, Diana van Heemst, Ko Willems van Dijk Tags: Original Research Source Type: research
Lipid-lowering optimisation for secondary prevention vascular and diabetic foot patients in a pharmacist-led clinic
Cardiovascular disease (CVD) is the leading cause of death accounting for a quarter of all deaths in the UK and more than 100,000 hospital admissions1. Stroke causes 38,000 deaths and 100,000 admissions in the UK annually2. Associated healthcare costs are estimated to be £9 billion every year with an overall CVD burden of approximately £19 billion annually3. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - March 29, 2024 Category: Lipidology Authors: Matthew Hart Mpharm, Jon Rees, Julia L Newton, Gerard Stansby, Kate Mackay, Ahai Luvai Tags: Original Research Source Type: research
Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn
β-Propeller protein-associated neurodegeneration (BPAN) is a genetic neurodegenerative disease caused by mutations in WDR45. The impairment of autophagy caused by WDR45 deficiency contributes to the pathogenesis ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 28, 2024 Category: Lipidology Authors: Qiuhong Xiong, Huimin Sun, Yanlin Wang, Qian Xu, Yu Zhang, Mei Xu, Zhonghua Zhao, Ping Li and Changxin Wu Tags: Research Source Type: research
Uric acid, high density lipoprotein cholesterol levels and their ratio are related to microbial enterotypes and serum metabolites in females with a blood stasis constitution
Blood stasis constitution in traditional Chinese medicine (TCM) is believed to render individuals more susceptible to metabolic diseases. However, the biological underpinnings of this constitutional imbalance ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 27, 2024 Category: Lipidology Authors: Chen Sun, Yanmin Liu, Wei Huang, Yang Chen, Yusheng Deng, Jiamin Yuan, Lili Deng, Ning Xu, Xiaoxiao Shang, Chuyang Wang, Zhimin Yang, Li Huang and Qinwei Qiu Tags: Research Source Type: research
The serum soluble ASGR1 concentration is elevated in patients with coronary artery disease and is associated with inflammatory markers
This study aimed to assess the correlation between ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 27, 2024 Category: Lipidology Authors: Qin Luo, Jingfei Chen, Yanfeng Yi, Panyun Wu, Yingjie Su, Zhangling Chen, Hac ı Ahmet Aydemir, Jianjun Tang, Zhenfei Fang and Fei Luo Tags: Research Source Type: research
Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism
The accumulation of reactive oxygen species (ROS) within the bone marrow microenvironment leads to diminished osteogenic differentiation and heightened lipogenic differentiation of mesenchymal stem cells resid... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - March 25, 2024 Category: Lipidology Authors: Jinying Li, Yongshao Chen, Dingsheng Zha, Chunhui Wu, Xiaofen Li, Li Yang, Hui Cao, Shexing Cai and Yuebo Cai Tags: Research Source Type: research
