You just finished residency. It ’s time to consider life insurance.
Here we are, coming down the home stretch and about to finish residency. With an increased income comes some new financial decisions. The need for life insurance is one of those decisions. If you don ’t have any, now would be a good time to consider getting some. The purpose of life insurance is to support […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 3, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/cory-fawcett" rel="tag" > Cory Fawcett, MD < /a > < /span > Tags: Finance Practice Management Source Type: blogs
Fight Aging! Newsletter, February 11th 2019
We report that the bone marrow stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feedback to promote AML blast survival and proliferation via the SASP.
Importantly, selective elimination of p16INK4a-positive senescent bone marrow stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model we show that by targeting NOX2 we reduced bone marrow stromal cell senescence and consequently reduced A...
Source: Fight Aging! - February 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reporting on the Longevity Leaders Conference
Some of the Life Extension Advocacy Foundation folk were at the recent Longevity Leaders conference in London, and wrote up a report on the event. The conference split up into three streams later in the day, one of which is followed here. Being focused on the pensions and life insurance industries as much as biotechnology, there were a lot of people present with minimal exposure to the prospects for rejuvenation and slowing of aging. It was noteworthy to see so many there being newly interested in the topic of treating aging as a medical condition, and motivated to learn more because it is important to their work in other ...
Source: Fight Aging! - February 8, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Notes on the Longevity Leaders Event, January 2019
LSX, a life science and biotechnology business networking organization, runs a yearly conference that took place in London this week. As a part of the festivities this year, the organizers added the Longevity Leaders event. This is one of a number of new conference series recently launched, in response to the great influx of funding and interest in the development of means to treat aging. Not all of that is rejuvenation biotechnology after the SENS model of damage repair, but a growing percentage is, even if that is near all a growing fleet of senolytics startups. A few years from now, we'll all have lost count of myriad m...
Source: Fight Aging! - February 7, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, December 17th 2018
In this study, we found that TNF-α resulted in an impairment of autophagic flux in microglia. Concomitantly, an increase of M1 marker expression and reduction of M2 marker expression were observed in TNF-α challenged microglia. Upregulation of autophagy via serum deprivation or pharmacologic activators (rapamycin and resveratrol) promoted microglia polarization toward M2 phenotype, as evidenced by suppressed M1 and elevated M2 gene expression, while inhibition of autophagy with 3-MA or Atg5 siRNA consistently aggravated the M1 polarization induced by TNF-α.
Moreover, Atg5 knockdown alone was sufficient to trigger...
Source: Fight Aging! - December 16, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Selection of Opposing Views on Cryonics
Cryopreservation via a cryonics provider, such as Alcor or the Cryonics Institute in the US, is presently the only option available to the billions who will age to death prior to the advent of a comprehensive package of rejuvenation therapies. Sadly, it is not yet a well-developed industry, operating at scale. The technology exists to vitrify people immediately following clinical death, preserving the fine structure of brain tissue if the vitrification process is of sufficiently high quality, but very few people choose to take advantage of this opportunity. Every year, tens of millions go to oblivion rather than chose the ...
Source: Fight Aging! - December 11, 2018 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, December 10th 2018
In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging.
Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes
https://www.fightaging.org/archives/2018/12/reducing-levels-of-protein-manufacture-slows-measures-of-aging-in-nematodes/
Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the co...
Source: Fight Aging! - December 9, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Longevity Science is Pretty Much Impenetrable for Journalists
Today I'll point out a recent media article that comments on RAADfest 2018, held in San Diego earlier this year. I attended this year, and wrote up my own thoughts on the event shortly thereafter. The advent of the first working, low cost, narrow focus rejuvenation therapies in the form of senolytic drugs capable of selectively destroying senescent cells is causing a sizable, but slow, shift of alignment and focus in both the scientific community and the historically fraud-ridden "anti-aging" marketplace. RAADfest is where these two communities meet, which makes it an interesting study if you have some insight into the his...
Source: Fight Aging! - December 5, 2018 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, November 12th 2018
This study's researchers approached all people turning 85 in 2006 in two cities in the UK for participation. At the beginning of the study in 2006-2007, there were 722 participants, 60 percent of whom were women. The participants provided researchers with information about what they ate every day, their body weight and height measurements, their overall health assessment (including any level of disability), and their medical records.
The researchers learned that more than one-quarter (28 percent) of very old adults had protein intakes below the recommended dietary allowance. The researchers noted that older adults w...
Source: Fight Aging! - November 11, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes on the 2018 Longevity Forum in London
The Longevity Forum, hosted by investor Jim Mellon and company yesterday in London, was a reminder that we still have a way to go when it comes to guiding the conversation on longevity and rejuvenation in a useful direction. On the one hand, most people give medicine and aging little serious thought until it is too late, and if we want large-scale funding for the goal of human rejuvenation through realization of the SENS research agenda, then the public at large really has to be on board in the same way that they are reflexively in favor of doing something about cancer and Alzheimer's disease. On the other hand, the first ...
Source: Fight Aging! - November 6, 2018 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Listen to This to Hear “2 Truths and a Lie” About Life with Depression
Fan favorite Two Truths and a Lie is back again! Listen to our hosts play the ever-popular game with the caveat that all the stories must center around depression and depression symptoms.
Michelle kicks us off telling stories of her college days and skipping class; Gabe follows up with his high school days of being too depressed to go to class. In round two, Michelle discusses her religious experiences, while Gabe recounts the potentially true story of calling his insurance company to make sure his life insurance will pay out on his death.
Finally, Michelle brings death, taxes, and guns into the mix, while Gabe tells...
Source: World of Psychology - October 22, 2018 Category: Psychiatry & Psychology Authors: A Bipolar, a Schizophrenic, and a Podcast Tags: A Bipolar, A Schizophrenic, and a Podcast Depression Schizophrenia Suicide Source Type: blogs
Fight Aging! Newsletter, October 15th 2018
This study suggests that exocrine glands can be induced from pluripotent stem cells for organ replacement regenerative therapy.
Replacement of Aged Microglia Partially Reverses Cognitive Decline in Mice
https://www.fightaging.org/archives/2018/10/replacement-of-aged-microglia-partially-reverses-cognitive-decline-in-mice/
Researchers here report on a compelling demonstration that shows the degree to which dysfunctional microglia contribute to age-related neurodegeneration. The scientists use a pharmacological approach to greatly deplete the microglial population and then allow it to recover naturally. Th...
Source: Fight Aging! - October 14, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is Crowdfunding The Grim Future of Health Insurance?
A growing number of people, mostly Americans, is forced to use crowdfunding sites to ask for money to cover medical expenses. While in many cases, the option is a potential source of hope binding people together for a good cause that would otherwise be lost due to financial reasons, the phenomenon also shows the desperate state of a healthcare system where victims of terrible illnesses have to “commodify” themselves on online donation forums. Should it stay that way? Should we fear for a dark future of health insurance in some parts of the world?
The patchwork called crowdfunding
Kickstarter, GoFundMe, Indiegogo, Crowd...
Source: The Medical Futurist - October 13, 2018 Category: Information Technology Authors: nora Tags: Health Insurance Healthcare Design Social media in Healthcare crowdfunding digital health digital health insurance ethics future health data medical medical expenses Source Type: blogs
Deciding How Much Life is Enough: Another Way to Sabotage Your Future Self
We are adept at sabotaging the person we will be. Time preference is a tyrannical aspect of the human condition; we aggressively and instinctively discount the value of everything in the decades ahead, even our own lives. People let their health run down through lack of maintenance, sabotaging their future selves of two decades hence. Another more subtle manifestation is the decision made on just how much life is enough life. The infrastructure of savings, retirement, life insurance, our peers and our families, our stories, our cultural myths and traditions, all are geared towards a life of a certain shape and length. We a...
Source: Fight Aging! - October 9, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Will Apple Track Your Mind, Not Just Your Heart?
By MICHAEL MILLENSON
If your heart throbs with desire for the new Apple Watch, the Series 4 itself can track that pitter-pat through its much-publicized ability to provide continuous heart rate readings.
On the other hand, if you’re depressed that you didn’t buy Apple stock years ago, your iPhone’s Face ID might be able to discover your dismay and connect you to a therapist.
In its recent rollout of the Apple Watch, company chief operating officer Jeff Williams enthused that the device could become “an intelligent guardian for your health.” Apple watching over your health, however, might involve much more tha...
Source: The Health Care Blog - September 27, 2018 Category: Consumer Health News Authors: matthew holt Tags: Apple Artificial Intelligence health care monitoring systems smart devices Source Type: blogs
