Fight Aging! Newsletter, February 11th 2019

We report that the bone marrow stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feedback to promote AML blast survival and proliferation via the SASP. Importantly, selective elimination of p16INK4a-positive senescent bone marrow stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model we show that by targeting NOX2 we reduced bone marrow stromal cell senescence and consequently reduced AML proliferation. Together, these data identify leukemia generated NOX2 derived superoxide as a driver of pro-tumoral p16INK4a-dependent senescence in bone marrow stromal cells. Our findings reveal the importance of a senescent microenvironment for the pathophysiology of leukemia. These data now open the door to investigate drugs which specifically target the 'benign' senescent cells that surround and support AML. Autophagy is Everywhere in Aging https://www.fightaging.org/archives/2019/02/autophagy-is-everywhere-in-aging/ Researchers who work on autophagy might well feel justified in issuing the claim that the processes of autophagy are involved in near every aspect of aging. Autophagy is cellular housekeeping, the recycling of damaged or unwanted structures and molecules inside the cell. In chaperone-mediated autophagy, very selective ch...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

Related Links:

We report the case of a 53 year-old male presenting with hematuria, pain and induration of the penis 2 and half years after the diagnosis of left colon cancer. CT scan demonstrated involvement of the corpus spongiosum and corpora cavernosa with enlarged external inguinal lymph nodes and asymptomatic metastasis in the liver and lungs.The finding of a penile lesion in a cancer patient is an alarming sign and should indicate a disseminated disease. The prognosis of penile metastasis is poor.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 17 March 2019Source: Preventive MedicineAuthor(s): Aishwarya Vijay, Taeho Greg Rhee, Joseph S. RossAbstractThe United States is currently facing an epidemic of opioid-related deaths, increasingly associated with fentanyl use. Our objective was to characterize rates of fentanyl, general opioid and non-opioid pain medication prescription at a national level in both outpatient and emergency department settings. We used a retrospective cross-sectional research design using data from the 2006–2015 National Ambulatory Medical Care Surveys and National Hospital Ambulatory Medical Care Surv...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 16 March 2019Source: Preventive MedicineAuthor(s): Xuanzi Qin, Rebekah H. Nagler, Erika Franklin Fowler, Sarah E. GollustAbstractThe American Cancer Society and the U.S. Preventive Task Force recently recommended that women initiate routine breast cancer screening at older ages (45 and 50, respectively) than previously recommended, and both organizations emphasize the importance of weighing the harms of mammograms against the benefits in making informed decisions. However, little is known from national samples about how women perceive the harms and benefits of mammograms, and how these pe...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Authors: Lougiaki P, Tsolaki M, Pantazaki A Abstract Neurovascular dysfunction is a central process in the pathogenesis of the stroke and most neurodegenerative diseases, including Alzheimer's disease. The multi-cell neurovascular unit (NVU) combines the components of the neural, vascular and extracellular matrix (ECM) into an important interface whose proper function is critical to maintaining brain health. Tissue engineering now offers new tools and information to promote understanding of NVU's operation. A promising area for the development of NVU models is their bio-production through 3D bio-printing to produce...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Authors: Tzekaki E, Tsolaki M, Pantazaki A Abstract Alzheimer's disease (AD) is a serious neurodegenerative disorder that manifests itself as progressive damage to memory and knowledge and is the main cause of dementia in the elderly. AD is characterized by extracellular deposition of amyloid-β plate (Aβ) and by the formation of neurofibrillary tangles, composed of hyperphosphorylated Tau protein. These modifications lead to neuronal cell death, vascular dysfunction and inflammatory disorders. Described as "elderly disease", AD is an escalating threat to developed countries as life expectancy is...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Authors: Liakakis G Abstract Subcortical small-vessel disease (SSVD) is a disorder that has been fully described in clinical, neuropathological and imaging aspects. It is considered as the most prevalent ischemic CNS disorder and has been associated to arterial hypertension, diabetes mellitus, dyslipidemia and obstructive sleep apnea. The hallmark of SSVD is the ischemic white matter lesions which can be presented as lacunar infracts and global brain hypoperfusion in a common and homogeneous subtype of vascular cognitive impairment (VCI) which is often unrecognized. The special nature and course of SSVD offers the ...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Authors: Sarafidou S Abstract In neurodegenerative disorders such as dementia of the Alzheimer's type the person gradually loses skills and aspects of everyday living. Does that indicate that he/ she lose the self? In the past it was widely accepted that the self diminishes in dementia, until it is lost in the latest stage, yet in the recent years this premise has been challenged. Accepting that the self is "lost" can be problematic theoretically in the approach of self-hood, and practically in the care of individuals. Currently a novel perspective is "gaining ground" supporting the existence of...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Authors: Mavroudis I Abstract Alzheimer's disease (AD) is one of the main causes of dementia in the western world. It is clinically characterized by memory impairment, deterioration of intellectual faculties and loss of professional skills. AD brains exhibit significant atrophy, predominantly in the temporal and parietal lobes, while light microscopy reveals deposition of senile plaques and neurofibrillary degeneration initially in the entorhinal cortex, the hippocampus, and in the acoustic and visual cortices, in the frontal lobe and the cerebellum in the advanced stages. Dendritic and spinal pathology, as well as...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
CONCLUSION: The proposed method overcomes with the need of removing muscle artifacts on both realistic simulated EEG data and brain activity from people with cognitive impairment. PMID: 30877734 [PubMed - in process]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Authors: Kiousi V, Arnaoutoglou M, Printza A Abstract Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease that belongs to the group of motor neuron diseases. Motor deficits like reduce in tongue strength, may coexist with cognitive deficits compatible with frontotemporal dementia (FTD), also known as frontotemporal lobar degeneration (FTLD). FTD is a neurodegenerative syndrome with two main clinical variants: behavioral (bvFTD) and language or Primary Progressive Aphasia (PPA). ALS and FTD have significant clinical and neuropathological overlapping so that for some researchers they are ...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
More News: Academia | Acute Leukemia | Acute Myeloid Leukemia | Advertising | Antidoxidants | Biochemistry | Biology | Biotechnology | Brain | Brain Cancers | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer in Young Adults | Cardiology | Chemotherapy | China Health | Chronic Kidney Disease | Chronic Leukemia | Chronic Obstructive Pulmonary | Clinical Trials | Conferences | Dementia | Diabetes | Diabetes Type 2 | Diets | Disability | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Epithelial Cancer | Fish | Fortamet | Gastroschisis Repair | Genetics | Heart | Heart Cancer | Heart Transplant | Insulin | Insurance | Internet | Kidney Transplant | Laboratory Medicine | Learning | Leukemia | Life Insurance | Liver | Liver Transplant | Lung Transplant | Men | Metabolic Syndrome | Metformin | Mitochondria | Mitochondrial Disease | Molecular Biology | Neurology | Neuroscience | Nutrition | Obesity | Orthopaedics | Pensions | Physiology | Psychology | Research | Science | Scleroderma | Singapore Health | Skin | Sports Medicine | Stem Cell Therapy | Stem Cells | Study | Toxicology | Training | Turmeric | UK Health | Ultrasound | Universities | Universities & Medical Training | Urology & Nephrology | USA Health | Venture Capital | Websites