Kisspeptin decreases the adverse effects of human ovarian vitrification by regulating ROS-related apoptotic occurrences
In this study, the effects of kisspeptin on the improvement of the vitrification and thawing results of human ovarian tissues were investigated. In this work, 12 ovaries from patients who underwent hysterectomy were collected laparoscopically, and then 32 samples from each of their tissues were taken. Haematoxylin and eosin (H&E) staining was performed to check the normality of the ovarian tissue and, subsequently, the samples were allocated randomly into four groups, including: (1) fresh (control), (2) vitrification, (3) vitrified + 1 μM kisspeptin, and (4) vitrified + 10 μM kisspeptin groups. After vitrification, t...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Anahita Tavakoli Fereshteh Aliakbari Malek Soleimani Mehranjani Source Type: research
Obeticholic acid treatment of mice to promote fertilization and reproduction
Zygote. 2023 Sep 1:1-10. doi: 10.1017/S0967199423000400. Online ahead of print.ABSTRACTObeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, has been demonstrated to ameliorate the histopathological characteristics of liver damage. Nonetheless, the systemic safety profile of OCA with regard to reproduction and development remains poorly understood. In the present study, we conducted a dose-response experiment by administering OCA at doses of 5 mg/kg, 10 mg/kg, or 20 mg/kg through tube feeding to investigate its effect on reproductive development and fertilization rate in both male and female mice. Furthermore, we e...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Ming Liang Huailiang Yang Lanyong Xu Longqiao Cao Source Type: research
Kisspeptin decreases the adverse effects of human ovarian vitrification by regulating ROS-related apoptotic occurrences
In this study, the effects of kisspeptin on the improvement of the vitrification and thawing results of human ovarian tissues were investigated. In this work, 12 ovaries from patients who underwent hysterectomy were collected laparoscopically, and then 32 samples from each of their tissues were taken. Haematoxylin and eosin (H&E) staining was performed to check the normality of the ovarian tissue and, subsequently, the samples were allocated randomly into four groups, including: (1) fresh (control), (2) vitrification, (3) vitrified + 1 μM kisspeptin, and (4) vitrified + 10 μM kisspeptin groups. After vitrification, t...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Anahita Tavakoli Fereshteh Aliakbari Malek Soleimani Mehranjani Source Type: research
Obeticholic acid treatment of mice to promote fertilization and reproduction
Zygote. 2023 Sep 1:1-10. doi: 10.1017/S0967199423000400. Online ahead of print.ABSTRACTObeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, has been demonstrated to ameliorate the histopathological characteristics of liver damage. Nonetheless, the systemic safety profile of OCA with regard to reproduction and development remains poorly understood. In the present study, we conducted a dose-response experiment by administering OCA at doses of 5 mg/kg, 10 mg/kg, or 20 mg/kg through tube feeding to investigate its effect on reproductive development and fertilization rate in both male and female mice. Furthermore, we e...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Ming Liang Huailiang Yang Lanyong Xu Longqiao Cao Source Type: research
Kisspeptin decreases the adverse effects of human ovarian vitrification by regulating ROS-related apoptotic occurrences
In this study, the effects of kisspeptin on the improvement of the vitrification and thawing results of human ovarian tissues were investigated. In this work, 12 ovaries from patients who underwent hysterectomy were collected laparoscopically, and then 32 samples from each of their tissues were taken. Haematoxylin and eosin (H&E) staining was performed to check the normality of the ovarian tissue and, subsequently, the samples were allocated randomly into four groups, including: (1) fresh (control), (2) vitrification, (3) vitrified + 1 μM kisspeptin, and (4) vitrified + 10 μM kisspeptin groups. After vitrification, t...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Anahita Tavakoli Fereshteh Aliakbari Malek Soleimani Mehranjani Source Type: research
Obeticholic acid treatment of mice to promote fertilization and reproduction
Zygote. 2023 Sep 1:1-10. doi: 10.1017/S0967199423000400. Online ahead of print.ABSTRACTObeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, has been demonstrated to ameliorate the histopathological characteristics of liver damage. Nonetheless, the systemic safety profile of OCA with regard to reproduction and development remains poorly understood. In the present study, we conducted a dose-response experiment by administering OCA at doses of 5 mg/kg, 10 mg/kg, or 20 mg/kg through tube feeding to investigate its effect on reproductive development and fertilization rate in both male and female mice. Furthermore, we e...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Ming Liang Huailiang Yang Lanyong Xu Longqiao Cao Source Type: research
Kisspeptin decreases the adverse effects of human ovarian vitrification by regulating ROS-related apoptotic occurrences
In this study, the effects of kisspeptin on the improvement of the vitrification and thawing results of human ovarian tissues were investigated. In this work, 12 ovaries from patients who underwent hysterectomy were collected laparoscopically, and then 32 samples from each of their tissues were taken. Haematoxylin and eosin (H&E) staining was performed to check the normality of the ovarian tissue and, subsequently, the samples were allocated randomly into four groups, including: (1) fresh (control), (2) vitrification, (3) vitrified + 1 μM kisspeptin, and (4) vitrified + 10 μM kisspeptin groups. After vitrification, t...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Anahita Tavakoli Fereshteh Aliakbari Malek Soleimani Mehranjani Source Type: research
Obeticholic acid treatment of mice to promote fertilization and reproduction
Zygote. 2023 Sep 1:1-10. doi: 10.1017/S0967199423000400. Online ahead of print.ABSTRACTObeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, has been demonstrated to ameliorate the histopathological characteristics of liver damage. Nonetheless, the systemic safety profile of OCA with regard to reproduction and development remains poorly understood. In the present study, we conducted a dose-response experiment by administering OCA at doses of 5 mg/kg, 10 mg/kg, or 20 mg/kg through tube feeding to investigate its effect on reproductive development and fertilization rate in both male and female mice. Furthermore, we e...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Ming Liang Huailiang Yang Lanyong Xu Longqiao Cao Source Type: research
Kisspeptin decreases the adverse effects of human ovarian vitrification by regulating ROS-related apoptotic occurrences
In this study, the effects of kisspeptin on the improvement of the vitrification and thawing results of human ovarian tissues were investigated. In this work, 12 ovaries from patients who underwent hysterectomy were collected laparoscopically, and then 32 samples from each of their tissues were taken. Haematoxylin and eosin (H&E) staining was performed to check the normality of the ovarian tissue and, subsequently, the samples were allocated randomly into four groups, including: (1) fresh (control), (2) vitrification, (3) vitrified + 1 μM kisspeptin, and (4) vitrified + 10 μM kisspeptin groups. After vitrification, t...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Anahita Tavakoli Fereshteh Aliakbari Malek Soleimani Mehranjani Source Type: research
Obeticholic acid treatment of mice to promote fertilization and reproduction
Zygote. 2023 Sep 1:1-10. doi: 10.1017/S0967199423000400. Online ahead of print.ABSTRACTObeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, has been demonstrated to ameliorate the histopathological characteristics of liver damage. Nonetheless, the systemic safety profile of OCA with regard to reproduction and development remains poorly understood. In the present study, we conducted a dose-response experiment by administering OCA at doses of 5 mg/kg, 10 mg/kg, or 20 mg/kg through tube feeding to investigate its effect on reproductive development and fertilization rate in both male and female mice. Furthermore, we e...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Ming Liang Huailiang Yang Lanyong Xu Longqiao Cao Source Type: research
Kisspeptin decreases the adverse effects of human ovarian vitrification by regulating ROS-related apoptotic occurrences
In this study, the effects of kisspeptin on the improvement of the vitrification and thawing results of human ovarian tissues were investigated. In this work, 12 ovaries from patients who underwent hysterectomy were collected laparoscopically, and then 32 samples from each of their tissues were taken. Haematoxylin and eosin (H&E) staining was performed to check the normality of the ovarian tissue and, subsequently, the samples were allocated randomly into four groups, including: (1) fresh (control), (2) vitrification, (3) vitrified + 1 μM kisspeptin, and (4) vitrified + 10 μM kisspeptin groups. After vitrification, t...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Anahita Tavakoli Fereshteh Aliakbari Malek Soleimani Mehranjani Source Type: research
Obeticholic acid treatment of mice to promote fertilization and reproduction
Zygote. 2023 Sep 1:1-10. doi: 10.1017/S0967199423000400. Online ahead of print.ABSTRACTObeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, has been demonstrated to ameliorate the histopathological characteristics of liver damage. Nonetheless, the systemic safety profile of OCA with regard to reproduction and development remains poorly understood. In the present study, we conducted a dose-response experiment by administering OCA at doses of 5 mg/kg, 10 mg/kg, or 20 mg/kg through tube feeding to investigate its effect on reproductive development and fertilization rate in both male and female mice. Furthermore, we e...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Ming Liang Huailiang Yang Lanyong Xu Longqiao Cao Source Type: research
Kisspeptin decreases the adverse effects of human ovarian vitrification by regulating ROS-related apoptotic occurrences
In this study, the effects of kisspeptin on the improvement of the vitrification and thawing results of human ovarian tissues were investigated. In this work, 12 ovaries from patients who underwent hysterectomy were collected laparoscopically, and then 32 samples from each of their tissues were taken. Haematoxylin and eosin (H&E) staining was performed to check the normality of the ovarian tissue and, subsequently, the samples were allocated randomly into four groups, including: (1) fresh (control), (2) vitrification, (3) vitrified + 1 μM kisspeptin, and (4) vitrified + 10 μM kisspeptin groups. After vitrification, t...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Anahita Tavakoli Fereshteh Aliakbari Malek Soleimani Mehranjani Source Type: research
Obeticholic acid treatment of mice to promote fertilization and reproduction
Zygote. 2023 Sep 1:1-10. doi: 10.1017/S0967199423000400. Online ahead of print.ABSTRACTObeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, has been demonstrated to ameliorate the histopathological characteristics of liver damage. Nonetheless, the systemic safety profile of OCA with regard to reproduction and development remains poorly understood. In the present study, we conducted a dose-response experiment by administering OCA at doses of 5 mg/kg, 10 mg/kg, or 20 mg/kg through tube feeding to investigate its effect on reproductive development and fertilization rate in both male and female mice. Furthermore, we e...
Source: Zygote - September 1, 2023 Category: Reproduction Medicine Authors: Ming Liang Huailiang Yang Lanyong Xu Longqiao Cao Source Type: research
Therapeutic potential of nanotechnology in reproduction disorders and possible limitations
Zygote. 2023 Aug 4:1-8. doi: 10.1017/S0967199423000424. Online ahead of print.ABSTRACTOne of the prominent peculiarities of nanoparticles (NPs) is their ability to cross biological barriers. Therefore, the development of NPs with different properties has great therapeutic potential in the area of reproduction because the association of drugs, hormones and other compounds with NPs represents an alternative for delivering substances directly at a specific site and for treatment of reproductive problems. Additionally, lipid-based NPs can be taken up by the tissues of patients with ovarian failure, deep endometriosis, testicul...
Source: Zygote - August 4, 2023 Category: Reproduction Medicine Authors: Pedro Alves Aguiar Barroso Danisv ânia Ripardo Nascimento Miguel F De Lima Neto Ernando Igo T De Assis Ciro Siqueira Figueira Jos é Roberto Viana Silva Source Type: research
