Association Between Dysmenorrhea and Risk of Epilepsy in East Asian Populations: A Bidirectional Two-Sample Mendelian Randomization Study
This study investigated the causal relevance of dysmenorrhea on epilepsy using Mendelian randomization (MR). We extracted instrumental variants for dysmenorrhea and epilepsy from published genomewide association study data, focusing on individuals of East Asian descent. A comprehensive suite of MR estimations and sensitivity analyses was performed to ensure the robustness of the findings. Each outcome database was analyzed separately in both directions. For dysmenorrhea and epilepsy, 7 and 3 genetic variants respectively were selectively extracted as instrumental variants. The results suggest that dysmenorrhea is causally ...
Source: Twin Research and Human Genetics - December 15, 2023 Category: Genetics & Stem Cells Authors: Yuehan Ren Junning Zhang Tong Chen Jiaqin Chen Yan Liao Tingxiu Liu Liangliang Yang Chang Liu Xinmin Liu Baoqin Liu Source Type: research
National Trends in Suicides and Male Twin Live Births in the US, 2003 to 2019: An Updated Test of Collective Optimism and Selection in Utero
Twin Res Hum Genet. 2023 Dec 15:1-8. doi: 10.1017/thg.2023.49. Online ahead of print.ABSTRACTPrior research based on Swedish data suggests that collective optimism, as measured by monthly incidence of suicides, correlates inversely with selection in utero against male twins in a population. We test this finding in the US, which reports the highest suicide rate of all high-income countries, and examine whether monthly changes in overall suicides precede changes in the ratio of male twin to male singleton live births. Consistent with prior work, we also examine as a key independent variable, suicides among women aged 15-49 y...
Source: Twin Research and Human Genetics - December 15, 2023 Category: Genetics & Stem Cells Authors: Parvati Singh Samantha Gailey Abhery Das Tim A Bruckner Source Type: research
Comprehensive Multiomics Analysis of Monozygotic Twin Discordant for Double Outlet Right Ventricle
This study demonstrates a multiomics profile of discordant twins and explores the possible mechanism of DORV development. Global hypomethylation might be associated with the risk of CHDs. Specific genes and specific pathways, particularly those involving ECM-receptor interaction, focal adhesion and TGF-β signaling, might be involved in the occurrence of CHDs.PMID:38099413 | DOI:10.1017/thg.2023.51 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - December 15, 2023 Category: Genetics & Stem Cells Authors: Zhen Liu Nana Li Xiaoyu Pan Jun Li Shengli Li Qintong Li Ping Li Ying Deng Fang Chen Hui Jiang Wei Wang Dezhi Mu Ping Yu Jun Zhu Source Type: research
Association Between Dysmenorrhea and Risk of Epilepsy in East Asian Populations: A Bidirectional Two-Sample Mendelian Randomization Study
This study investigated the causal relevance of dysmenorrhea on epilepsy using Mendelian randomization (MR). We extracted instrumental variants for dysmenorrhea and epilepsy from published genomewide association study data, focusing on individuals of East Asian descent. A comprehensive suite of MR estimations and sensitivity analyses was performed to ensure the robustness of the findings. Each outcome database was analyzed separately in both directions. For dysmenorrhea and epilepsy, 7 and 3 genetic variants respectively were selectively extracted as instrumental variants. The results suggest that dysmenorrhea is causally ...
Source: Twin Research and Human Genetics - December 15, 2023 Category: Genetics & Stem Cells Authors: Yuehan Ren Junning Zhang Tong Chen Jiaqin Chen Yan Liao Tingxiu Liu Liangliang Yang Chang Liu Xinmin Liu Baoqin Liu Source Type: research
National Trends in Suicides and Male Twin Live Births in the US, 2003 to 2019: An Updated Test of Collective Optimism and Selection in Utero
Twin Res Hum Genet. 2023 Dec 15:1-8. doi: 10.1017/thg.2023.49. Online ahead of print.ABSTRACTPrior research based on Swedish data suggests that collective optimism, as measured by monthly incidence of suicides, correlates inversely with selection in utero against male twins in a population. We test this finding in the US, which reports the highest suicide rate of all high-income countries, and examine whether monthly changes in overall suicides precede changes in the ratio of male twin to male singleton live births. Consistent with prior work, we also examine as a key independent variable, suicides among women aged 15-49 y...
Source: Twin Research and Human Genetics - December 15, 2023 Category: Genetics & Stem Cells Authors: Parvati Singh Samantha Gailey Abhery Das Tim A Bruckner Source Type: research
Comprehensive Multiomics Analysis of Monozygotic Twin Discordant for Double Outlet Right Ventricle
This study demonstrates a multiomics profile of discordant twins and explores the possible mechanism of DORV development. Global hypomethylation might be associated with the risk of CHDs. Specific genes and specific pathways, particularly those involving ECM-receptor interaction, focal adhesion and TGF-β signaling, might be involved in the occurrence of CHDs.PMID:38099413 | DOI:10.1017/thg.2023.51 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - December 15, 2023 Category: Genetics & Stem Cells Authors: Zhen Liu Nana Li Xiaoyu Pan Jun Li Shengli Li Qintong Li Ping Li Ying Deng Fang Chen Hui Jiang Wei Wang Dezhi Mu Ping Yu Jun Zhu Source Type: research
Association Between Dysmenorrhea and Risk of Epilepsy in East Asian Populations: A Bidirectional Two-Sample Mendelian Randomization Study
This study investigated the causal relevance of dysmenorrhea on epilepsy using Mendelian randomization (MR). We extracted instrumental variants for dysmenorrhea and epilepsy from published genomewide association study data, focusing on individuals of East Asian descent. A comprehensive suite of MR estimations and sensitivity analyses was performed to ensure the robustness of the findings. Each outcome database was analyzed separately in both directions. For dysmenorrhea and epilepsy, 7 and 3 genetic variants respectively were selectively extracted as instrumental variants. The results suggest that dysmenorrhea is causally ...
Source: Twin Research and Human Genetics - December 15, 2023 Category: Genetics & Stem Cells Authors: Yuehan Ren Junning Zhang Tong Chen Jiaqin Chen Yan Liao Tingxiu Liu Liangliang Yang Chang Liu Xinmin Liu Baoqin Liu Source Type: research
National Trends in Suicides and Male Twin Live Births in the US, 2003 to 2019: An Updated Test of Collective Optimism and Selection in Utero
Twin Res Hum Genet. 2023 Dec 15:1-8. doi: 10.1017/thg.2023.49. Online ahead of print.ABSTRACTPrior research based on Swedish data suggests that collective optimism, as measured by monthly incidence of suicides, correlates inversely with selection in utero against male twins in a population. We test this finding in the US, which reports the highest suicide rate of all high-income countries, and examine whether monthly changes in overall suicides precede changes in the ratio of male twin to male singleton live births. Consistent with prior work, we also examine as a key independent variable, suicides among women aged 15-49 y...
Source: Twin Research and Human Genetics - December 15, 2023 Category: Genetics & Stem Cells Authors: Parvati Singh Samantha Gailey Abhery Das Tim A Bruckner Source Type: research
Comprehensive Multiomics Analysis of Monozygotic Twin Discordant for Double Outlet Right Ventricle
This study demonstrates a multiomics profile of discordant twins and explores the possible mechanism of DORV development. Global hypomethylation might be associated with the risk of CHDs. Specific genes and specific pathways, particularly those involving ECM-receptor interaction, focal adhesion and TGF-β signaling, might be involved in the occurrence of CHDs.PMID:38099413 | DOI:10.1017/thg.2023.51 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - December 15, 2023 Category: Genetics & Stem Cells Authors: Zhen Liu Nana Li Xiaoyu Pan Jun Li Shengli Li Qintong Li Ping Li Ying Deng Fang Chen Hui Jiang Wei Wang Dezhi Mu Ping Yu Jun Zhu Source Type: research
Association Between Dysmenorrhea and Risk of Epilepsy in East Asian Populations: A Bidirectional Two-Sample Mendelian Randomization Study
This study investigated the causal relevance of dysmenorrhea on epilepsy using Mendelian randomization (MR). We extracted instrumental variants for dysmenorrhea and epilepsy from published genomewide association study data, focusing on individuals of East Asian descent. A comprehensive suite of MR estimations and sensitivity analyses was performed to ensure the robustness of the findings. Each outcome database was analyzed separately in both directions. For dysmenorrhea and epilepsy, 7 and 3 genetic variants respectively were selectively extracted as instrumental variants. The results suggest that dysmenorrhea is causally ...
Source: Twin Research and Human Genetics - December 15, 2023 Category: Genetics & Stem Cells Authors: Yuehan Ren Junning Zhang Tong Chen Jiaqin Chen Yan Liao Tingxiu Liu Liangliang Yang Chang Liu Xinmin Liu Baoqin Liu Source Type: research
Review of < em > The Twin Children of the Holocaust: Stolen Childhood and the Will to Survive < /em > , by Nancy L. Segal - CORRIGENDUM
Twin Res Hum Genet. 2023 Dec 1:1. doi: 10.1017/thg.2023.47. Online ahead of print.NO ABSTRACTPMID:38037823 | DOI:10.1017/thg.2023.47 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - December 1, 2023 Category: Genetics & Stem Cells Authors: Jeffrey M Craig Source Type: research
Review of < em > The Twin Children of the Holocaust: Stolen Childhood and the Will to Survive < /em > , by Nancy L. Segal - CORRIGENDUM
Twin Res Hum Genet. 2023 Dec 1:1. doi: 10.1017/thg.2023.47. Online ahead of print.NO ABSTRACTPMID:38037823 | DOI:10.1017/thg.2023.47 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - December 1, 2023 Category: Genetics & Stem Cells Authors: Jeffrey M Craig Source Type: research
Review of < em > The Twin Children of the Holocaust: Stolen Childhood and the Will to Survive < /em > , by Nancy L. Segal - CORRIGENDUM
Twin Res Hum Genet. 2023 Dec 1:1. doi: 10.1017/thg.2023.47. Online ahead of print.NO ABSTRACTPMID:38037823 | DOI:10.1017/thg.2023.47 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - December 1, 2023 Category: Genetics & Stem Cells Authors: Jeffrey M Craig Source Type: research
Review of < em > The Twin Children of the Holocaust: Stolen Childhood and the Will to Survive < /em > , by Nancy L. Segal - CORRIGENDUM
Twin Res Hum Genet. 2023 Dec 1:1. doi: 10.1017/thg.2023.47. Online ahead of print.NO ABSTRACTPMID:38037823 | DOI:10.1017/thg.2023.47 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - December 1, 2023 Category: Genetics & Stem Cells Authors: Jeffrey M Craig Source Type: research
Review of < em > The Twin Children of the Holocaust: Stolen Childhood and the Will to Survive < /em > , by Nancy L. Segal - CORRIGENDUM
Twin Res Hum Genet. 2023 Dec 1:1. doi: 10.1017/thg.2023.47. Online ahead of print.NO ABSTRACTPMID:38037823 | DOI:10.1017/thg.2023.47 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - December 1, 2023 Category: Genetics & Stem Cells Authors: Jeffrey M Craig Source Type: research
