The Co-Twin Control Design: Implementation and Methodological Considerations
This article introduces the CTCD and offers an overview of analysis methods for binary and continuous outcome and exposure variables. Tools for data simulation are provided, along with practical guidance and accompanying scripts for implementing the CTCD in R, SPSS, and Stata. While the CTCD offers valuable insights into causal inference, it depends on several assumptions that are important when interpreting CTCD results. By presenting a broad overview of the CTCD, this article aims to equip researchers with actionable recommendations and a comprehensive understanding of the design's strengths and limitations.PMID:37655521...
Source: Twin Research and Human Genetics - September 1, 2023 Category: Genetics & Stem Cells Authors: Bodine M A Gonggrijp Steve G A van de Weijer Catrien C J H Bijleveld Jenny van Dongen Dorret I Boomsma Source Type: research
Mitochondrial DNA Copy Number and Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia
This report specifically focuses on the assessment of changes in the mitochondrial genome in a unique set of monozygotic twins discordant (MZD) for SZ using blood. Genomic DNA from six pairs of MZD twins and two sets of parents (N = 16) was hybridized to the Affymetrix Human SNP Array 6.0 to assess mitochondrial DNA copy number (mtDNA-CN). Whole genome sequencing (WGS) and quantitative polymerase chain reaction (qPCR) was performed for a subset of MZD pairs and their parents and was also used to derive mtDNA-CN estimates. The WGS data were further analyzed to generate heteroplasmy (HP) estimates. Our results show that mtDN...
Source: Twin Research and Human Genetics - September 1, 2023 Category: Genetics & Stem Cells Authors: Phyo W Win Shiva M Singh Christina A Castellani Source Type: research
Early Spontaneous Twinning Recorded By Time-Lapse
We present the complete TL record of one case of MZT that split itself at the very moment of the division into two cells, with one of the cells coming out through a hole in the zona pellucida (ZP). Both resulting embryos developed normally, and were vitrified. It is suggested that the hole in the ZP may facilitate the extrusion of some cells of the <day 4 embryo and that this cell development is not constrained by being inside the ZP. Despite the lack of the inhibition of the ZP itself or the influence of the other embryo cells, the totipotent cell was then able to develop correctly from the start. Moreover, the embryo ...
Source: Twin Research and Human Genetics - September 1, 2023 Category: Genetics & Stem Cells Authors: Roberto Matorras Alberto Vendrell Marcos Ferrando Zaloa Larreategui Source Type: research
The Co-Twin Control Design: Implementation and Methodological Considerations
This article introduces the CTCD and offers an overview of analysis methods for binary and continuous outcome and exposure variables. Tools for data simulation are provided, along with practical guidance and accompanying scripts for implementing the CTCD in R, SPSS, and Stata. While the CTCD offers valuable insights into causal inference, it depends on several assumptions that are important when interpreting CTCD results. By presenting a broad overview of the CTCD, this article aims to equip researchers with actionable recommendations and a comprehensive understanding of the design's strengths and limitations.PMID:37655521...
Source: Twin Research and Human Genetics - September 1, 2023 Category: Genetics & Stem Cells Authors: Bodine M A Gonggrijp Steve G A van de Weijer Catrien C J H Bijleveld Jenny van Dongen Dorret I Boomsma Source Type: research
Mitochondrial DNA Copy Number and Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia
This report specifically focuses on the assessment of changes in the mitochondrial genome in a unique set of monozygotic twins discordant (MZD) for SZ using blood. Genomic DNA from six pairs of MZD twins and two sets of parents (N = 16) was hybridized to the Affymetrix Human SNP Array 6.0 to assess mitochondrial DNA copy number (mtDNA-CN). Whole genome sequencing (WGS) and quantitative polymerase chain reaction (qPCR) was performed for a subset of MZD pairs and their parents and was also used to derive mtDNA-CN estimates. The WGS data were further analyzed to generate heteroplasmy (HP) estimates. Our results show that mtDN...
Source: Twin Research and Human Genetics - September 1, 2023 Category: Genetics & Stem Cells Authors: Phyo W Win Shiva M Singh Christina A Castellani Source Type: research
Early Spontaneous Twinning Recorded By Time-Lapse
We present the complete TL record of one case of MZT that split itself at the very moment of the division into two cells, with one of the cells coming out through a hole in the zona pellucida (ZP). Both resulting embryos developed normally, and were vitrified. It is suggested that the hole in the ZP may facilitate the extrusion of some cells of the <day 4 embryo and that this cell development is not constrained by being inside the ZP. Despite the lack of the inhibition of the ZP itself or the influence of the other embryo cells, the totipotent cell was then able to develop correctly from the start. Moreover, the embryo ...
Source: Twin Research and Human Genetics - September 1, 2023 Category: Genetics & Stem Cells Authors: Roberto Matorras Alberto Vendrell Marcos Ferrando Zaloa Larreategui Source Type: research
Maternal and Neonatal Outcomes of Twin Pregnant Women With Anemia
Twin Res Hum Genet. 2023 Aug 31:1-6. doi: 10.1017/thg.2023.33. Online ahead of print.ABSTRACTThe aim of this study was to investigate the prevalence of anemia in twin pregnancies and the influence of anemia on maternal and neonatal outcomes. This retrospective study included twin pregnant women who delivered in a tertiary hospital in China from January 2018 to December 2018. Patients were divided by WHO criteria (hemoglobin <11.0 g/dL): the anemic and nonanemic groups. Patients with anemia were further classified as recovered or unrecovered subgroup after oral iron therapy. Maternal and neonatal outcomes in women carryi...
Source: Twin Research and Human Genetics - August 31, 2023 Category: Genetics & Stem Cells Authors: Nacheng Lin Ping Shen Huilian Hu Wenying Song Yali Hu Yimin Dai Yi-Hua Zhou Source Type: research
Genetic and Environmental Influences on Blood Pressure and Serum Lipids Across Age-Groups
In this study, data from the Chinese National Twin Registry (CNTR) were used. Resting blood pressure, including systolic and diastolic blood pressure (SBP and DBP), and fasting serum lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) were measured in 2378 participants (1189 twin pairs). Univariate and bivariate structural equation models examined the genetic and environmental influences on blood pressure and serum lipids among three age groups. All phenotypes showed moderate to high heritability (0.37-0.59) and moderate...
Source: Twin Research and Human Genetics - August 31, 2023 Category: Genetics & Stem Cells Authors: Ke Miao Yutong Wang Weihua Cao Jun Lv Canqing Yu Tao Huang Dianjianyi Sun Chunxiao Liao Yuanjie Pang Runhua Hu Zengchang Pang Min Yu Hua Wang Xianping Wu Yu Liu Wenjing Gao Liming Li Source Type: research
Maternal and Neonatal Outcomes of Twin Pregnant Women With Anemia
Twin Res Hum Genet. 2023 Aug 31:1-6. doi: 10.1017/thg.2023.33. Online ahead of print.ABSTRACTThe aim of this study was to investigate the prevalence of anemia in twin pregnancies and the influence of anemia on maternal and neonatal outcomes. This retrospective study included twin pregnant women who delivered in a tertiary hospital in China from January 2018 to December 2018. Patients were divided by WHO criteria (hemoglobin <11.0 g/dL): the anemic and nonanemic groups. Patients with anemia were further classified as recovered or unrecovered subgroup after oral iron therapy. Maternal and neonatal outcomes in women carryi...
Source: Twin Research and Human Genetics - August 31, 2023 Category: Genetics & Stem Cells Authors: Nacheng Lin Ping Shen Huilian Hu Wenying Song Yali Hu Yimin Dai Yi-Hua Zhou Source Type: research
Genetic and Environmental Influences on Blood Pressure and Serum Lipids Across Age-Groups
In this study, data from the Chinese National Twin Registry (CNTR) were used. Resting blood pressure, including systolic and diastolic blood pressure (SBP and DBP), and fasting serum lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) were measured in 2378 participants (1189 twin pairs). Univariate and bivariate structural equation models examined the genetic and environmental influences on blood pressure and serum lipids among three age groups. All phenotypes showed moderate to high heritability (0.37-0.59) and moderate...
Source: Twin Research and Human Genetics - August 31, 2023 Category: Genetics & Stem Cells Authors: Ke Miao Yutong Wang Weihua Cao Jun Lv Canqing Yu Tao Huang Dianjianyi Sun Chunxiao Liao Yuanjie Pang Runhua Hu Zengchang Pang Min Yu Hua Wang Xianping Wu Yu Liu Wenjing Gao Liming Li Source Type: research
The 18th International Twin Congress, and a Look at Twin Research in Wales/Twin Research Reviews: Temperamental Similarities and Twin Relations; Maximizing Twin Designs; Rare Tubal Ectopic Pregnancy; Twins' Academic Self-Concept Formation/In the Media: Identical Infant Twins Reunited; Birth of Identical-Fraternal Quadruplets; Identical Twin Comedians; 'Twice in a Lifetime': Meeting an Unrelated Look-Alike; Twins in the Tour de France
Twin Res Hum Genet. 2023 Aug 29:1-6. doi: 10.1017/thg.2023.31. Online ahead of print.ABSTRACTThe 18th International Society for Twin Studies convention took place between June 15-17, 2023, in Budapest, Hungary. A selective sampling of highlights from the meeting are presented. This is followed by a brief overview of ongoing twin research at the University of Aberystwyth in Wales and some twin treasures in the National Library. Next, reviews of timely research that examine temperamental similarities and twin relations, the maximization of twin research designs, a rare ectopic twin pregnancy, and twins' academic self-concept...
Source: Twin Research and Human Genetics - August 29, 2023 Category: Genetics & Stem Cells Authors: Nancy L Segal Source Type: research
The 18th International Twin Congress, and a Look at Twin Research in Wales/Twin Research Reviews: Temperamental Similarities and Twin Relations; Maximizing Twin Designs; Rare Tubal Ectopic Pregnancy; Twins' Academic Self-Concept Formation/In the Media: Identical Infant Twins Reunited; Birth of Identical-Fraternal Quadruplets; Identical Twin Comedians; 'Twice in a Lifetime': Meeting an Unrelated Look-Alike; Twins in the Tour de France
Twin Res Hum Genet. 2023 Aug 29:1-6. doi: 10.1017/thg.2023.31. Online ahead of print.ABSTRACTThe 18th International Society for Twin Studies convention took place between June 15-17, 2023, in Budapest, Hungary. A selective sampling of highlights from the meeting are presented. This is followed by a brief overview of ongoing twin research at the University of Aberystwyth in Wales and some twin treasures in the National Library. Next, reviews of timely research that examine temperamental similarities and twin relations, the maximization of twin research designs, a rare ectopic twin pregnancy, and twins' academic self-concept...
Source: Twin Research and Human Genetics - August 29, 2023 Category: Genetics & Stem Cells Authors: Nancy L Segal Source Type: research
Human Genetics Society of Australasia Position Statement: Genetic Testing and Personal Insurance Products in Australia - CORRIGENDUM
Twin Res Hum Genet. 2023 Aug 29:1. doi: 10.1017/thg.2023.36. Online ahead of print.NO ABSTRACTPMID:37640686 | DOI:10.1017/thg.2023.36 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - August 28, 2023 Category: Genetics & Stem Cells Authors: Aideen M McInerney-Leo Samantha Ayres Jackie Boyle Chris Jacobs Ainsley J Newson Source Type: research
Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population
Twin Res Hum Genet. 2023 Jul 25:1-7. doi: 10.1017/thg.2023.28. Online ahead of print.ABSTRACTThe purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of geneti...
Source: Twin Research and Human Genetics - July 25, 2023 Category: Genetics & Stem Cells Authors: Raikhan Y Tuleutayeva Assem R Makhatova Saule O Rakhyzhanova Lashyn K Zhazykbayeva Dana K Kozhakhmetova Source Type: research
Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population
Twin Res Hum Genet. 2023 Jul 25:1-7. doi: 10.1017/thg.2023.28. Online ahead of print.ABSTRACTThe purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of geneti...
Source: Twin Research and Human Genetics - July 25, 2023 Category: Genetics & Stem Cells Authors: Raikhan Y Tuleutayeva Assem R Makhatova Saule O Rakhyzhanova Lashyn K Zhazykbayeva Dana K Kozhakhmetova Source Type: research
