Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance
Twin Res Hum Genet. 2023 Oct 6:1-12. doi: 10.1017/thg.2023.40. Online ahead of print.ABSTRACTThe current study explored the impact of genetic relatedness differences (ΔH) and sample size on the performance of nonclassical ACE models, with a focus on same-sex and opposite-sex twin groups. The ACE model is a statistical model that posits that additive genetic factors (A), common environmental factors (C), and specific (or nonshared) environmental factors plus measurement error (E) account for individual differences in a phenotype. By extending Visscher's (2004) least squares paradigm and conducting simulations, we illustrat...
Source: Twin Research and Human Genetics - October 6, 2023 Category: Genetics & Stem Cells Authors: Xuanyu Lyu S Mason Garrison Source Type: research
Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance
Twin Res Hum Genet. 2023 Oct 6:1-12. doi: 10.1017/thg.2023.40. Online ahead of print.ABSTRACTThe current study explored the impact of genetic relatedness differences (ΔH) and sample size on the performance of nonclassical ACE models, with a focus on same-sex and opposite-sex twin groups. The ACE model is a statistical model that posits that additive genetic factors (A), common environmental factors (C), and specific (or nonshared) environmental factors plus measurement error (E) account for individual differences in a phenotype. By extending Visscher's (2004) least squares paradigm and conducting simulations, we illustrat...
Source: Twin Research and Human Genetics - October 6, 2023 Category: Genetics & Stem Cells Authors: Xuanyu Lyu S Mason Garrison Source Type: research
Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance
Twin Res Hum Genet. 2023 Oct 6:1-12. doi: 10.1017/thg.2023.40. Online ahead of print.ABSTRACTThe current study explored the impact of genetic relatedness differences (ΔH) and sample size on the performance of nonclassical ACE models, with a focus on same-sex and opposite-sex twin groups. The ACE model is a statistical model that posits that additive genetic factors (A), common environmental factors (C), and specific (or nonshared) environmental factors plus measurement error (E) account for individual differences in a phenotype. By extending Visscher's (2004) least squares paradigm and conducting simulations, we illustrat...
Source: Twin Research and Human Genetics - October 6, 2023 Category: Genetics & Stem Cells Authors: Xuanyu Lyu S Mason Garrison Source Type: research
Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance
Twin Res Hum Genet. 2023 Oct 6:1-12. doi: 10.1017/thg.2023.40. Online ahead of print.ABSTRACTThe current study explored the impact of genetic relatedness differences (ΔH) and sample size on the performance of nonclassical ACE models, with a focus on same-sex and opposite-sex twin groups. The ACE model is a statistical model that posits that additive genetic factors (A), common environmental factors (C), and specific (or nonshared) environmental factors plus measurement error (E) account for individual differences in a phenotype. By extending Visscher's (2004) least squares paradigm and conducting simulations, we illustrat...
Source: Twin Research and Human Genetics - October 6, 2023 Category: Genetics & Stem Cells Authors: Xuanyu Lyu S Mason Garrison Source Type: research
Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance
Twin Res Hum Genet. 2023 Oct 6:1-12. doi: 10.1017/thg.2023.40. Online ahead of print.ABSTRACTThe current study explored the impact of genetic relatedness differences (ΔH) and sample size on the performance of nonclassical ACE models, with a focus on same-sex and opposite-sex twin groups. The ACE model is a statistical model that posits that additive genetic factors (A), common environmental factors (C), and specific (or nonshared) environmental factors plus measurement error (E) account for individual differences in a phenotype. By extending Visscher's (2004) least squares paradigm and conducting simulations, we illustrat...
Source: Twin Research and Human Genetics - October 6, 2023 Category: Genetics & Stem Cells Authors: Xuanyu Lyu S Mason Garrison Source Type: research
A 10-Year Observational Study on Twin Pregnancy: Role of Fetal Sex Pairing on Obstetric Outcome
Twin Res Hum Genet. 2023 Sep 14:1-7. doi: 10.1017/thg.2023.38. Online ahead of print.ABSTRACTFetal sex contributes to the determination of obstetric outcome, as pregnancies carrying male babies seem to have an increased risk of maternal-fetal complications. Most studies have been conducted on singleton pregnancies, whereas less evidence is available for twins. A 10-year retrospective observational study was conducted on a cohort of 1180 women with twin pregnancy delivered at a single tertiary hospital. Clinical data on maternal characteristics, and obstetric and neonatal outcomes were collected, and the analysis was perfor...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Silvia Vannuccini Sara Bolzonella Chiara Colucci Costanza Nicchi Noemi Strambi Mariarosaria Di Tommaso Source Type: research
C. C. Li and Quasi-Random Mating
Twin Res Hum Genet. 2023 Sep 14:1-3. doi: 10.1017/thg.2023.37. Online ahead of print.ABSTRACTA simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies is stated and illustrated. The title 'Quasi-random mating' is proposed. Confusion about the Hardy-Weinberg principle can be avoided only if there is clear separation between the basic deterministic model and factors influencing a population's structure. Eighty years passed before C. C. Li coined the term 'pseudo-random mating'. The lesson taught by Li has not been taken on board.PMID:37706311 | DOI:10.1017/thg.2...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Alan E Stark Source Type: research
A 10-Year Observational Study on Twin Pregnancy: Role of Fetal Sex Pairing on Obstetric Outcome
Twin Res Hum Genet. 2023 Sep 14:1-7. doi: 10.1017/thg.2023.38. Online ahead of print.ABSTRACTFetal sex contributes to the determination of obstetric outcome, as pregnancies carrying male babies seem to have an increased risk of maternal-fetal complications. Most studies have been conducted on singleton pregnancies, whereas less evidence is available for twins. A 10-year retrospective observational study was conducted on a cohort of 1180 women with twin pregnancy delivered at a single tertiary hospital. Clinical data on maternal characteristics, and obstetric and neonatal outcomes were collected, and the analysis was perfor...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Silvia Vannuccini Sara Bolzonella Chiara Colucci Costanza Nicchi Noemi Strambi Mariarosaria Di Tommaso Source Type: research
C. C. Li and Quasi-Random Mating
Twin Res Hum Genet. 2023 Sep 14:1-3. doi: 10.1017/thg.2023.37. Online ahead of print.ABSTRACTA simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies is stated and illustrated. The title 'Quasi-random mating' is proposed. Confusion about the Hardy-Weinberg principle can be avoided only if there is clear separation between the basic deterministic model and factors influencing a population's structure. Eighty years passed before C. C. Li coined the term 'pseudo-random mating'. The lesson taught by Li has not been taken on board.PMID:37706311 | DOI:10.1017/thg.2...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Alan E Stark Source Type: research
A 10-Year Observational Study on Twin Pregnancy: Role of Fetal Sex Pairing on Obstetric Outcome
Twin Res Hum Genet. 2023 Sep 14:1-7. doi: 10.1017/thg.2023.38. Online ahead of print.ABSTRACTFetal sex contributes to the determination of obstetric outcome, as pregnancies carrying male babies seem to have an increased risk of maternal-fetal complications. Most studies have been conducted on singleton pregnancies, whereas less evidence is available for twins. A 10-year retrospective observational study was conducted on a cohort of 1180 women with twin pregnancy delivered at a single tertiary hospital. Clinical data on maternal characteristics, and obstetric and neonatal outcomes were collected, and the analysis was perfor...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Silvia Vannuccini Sara Bolzonella Chiara Colucci Costanza Nicchi Noemi Strambi Mariarosaria Di Tommaso Source Type: research
C. C. Li and Quasi-Random Mating
Twin Res Hum Genet. 2023 Sep 14:1-3. doi: 10.1017/thg.2023.37. Online ahead of print.ABSTRACTA simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies is stated and illustrated. The title 'Quasi-random mating' is proposed. Confusion about the Hardy-Weinberg principle can be avoided only if there is clear separation between the basic deterministic model and factors influencing a population's structure. Eighty years passed before C. C. Li coined the term 'pseudo-random mating'. The lesson taught by Li has not been taken on board.PMID:37706311 | DOI:10.1017/thg.2...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Alan E Stark Source Type: research
A 10-Year Observational Study on Twin Pregnancy: Role of Fetal Sex Pairing on Obstetric Outcome
Twin Res Hum Genet. 2023 Sep 14:1-7. doi: 10.1017/thg.2023.38. Online ahead of print.ABSTRACTFetal sex contributes to the determination of obstetric outcome, as pregnancies carrying male babies seem to have an increased risk of maternal-fetal complications. Most studies have been conducted on singleton pregnancies, whereas less evidence is available for twins. A 10-year retrospective observational study was conducted on a cohort of 1180 women with twin pregnancy delivered at a single tertiary hospital. Clinical data on maternal characteristics, and obstetric and neonatal outcomes were collected, and the analysis was perfor...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Silvia Vannuccini Sara Bolzonella Chiara Colucci Costanza Nicchi Noemi Strambi Mariarosaria Di Tommaso Source Type: research
C. C. Li and Quasi-Random Mating
Twin Res Hum Genet. 2023 Sep 14:1-3. doi: 10.1017/thg.2023.37. Online ahead of print.ABSTRACTA simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies is stated and illustrated. The title 'Quasi-random mating' is proposed. Confusion about the Hardy-Weinberg principle can be avoided only if there is clear separation between the basic deterministic model and factors influencing a population's structure. Eighty years passed before C. C. Li coined the term 'pseudo-random mating'. The lesson taught by Li has not been taken on board.PMID:37706311 | DOI:10.1017/thg.2...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Alan E Stark Source Type: research
A 10-Year Observational Study on Twin Pregnancy: Role of Fetal Sex Pairing on Obstetric Outcome
Twin Res Hum Genet. 2023 Sep 14:1-7. doi: 10.1017/thg.2023.38. Online ahead of print.ABSTRACTFetal sex contributes to the determination of obstetric outcome, as pregnancies carrying male babies seem to have an increased risk of maternal-fetal complications. Most studies have been conducted on singleton pregnancies, whereas less evidence is available for twins. A 10-year retrospective observational study was conducted on a cohort of 1180 women with twin pregnancy delivered at a single tertiary hospital. Clinical data on maternal characteristics, and obstetric and neonatal outcomes were collected, and the analysis was perfor...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Silvia Vannuccini Sara Bolzonella Chiara Colucci Costanza Nicchi Noemi Strambi Mariarosaria Di Tommaso Source Type: research
C. C. Li and Quasi-Random Mating
Twin Res Hum Genet. 2023 Sep 14:1-3. doi: 10.1017/thg.2023.37. Online ahead of print.ABSTRACTA simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies is stated and illustrated. The title 'Quasi-random mating' is proposed. Confusion about the Hardy-Weinberg principle can be avoided only if there is clear separation between the basic deterministic model and factors influencing a population's structure. Eighty years passed before C. C. Li coined the term 'pseudo-random mating'. The lesson taught by Li has not been taken on board.PMID:37706311 | DOI:10.1017/thg.2...
Source: Twin Research and Human Genetics - September 14, 2023 Category: Genetics & Stem Cells Authors: Alan E Stark Source Type: research
