Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population
Twin Res Hum Genet. 2023 Jul 25:1-7. doi: 10.1017/thg.2023.28. Online ahead of print.ABSTRACTThe purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of geneti...
Source: Twin Research and Human Genetics - July 25, 2023 Category: Genetics & Stem Cells Authors: Raikhan Y Tuleutayeva Assem R Makhatova Saule O Rakhyzhanova Lashyn K Zhazykbayeva Dana K Kozhakhmetova Source Type: research
Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population
Twin Res Hum Genet. 2023 Jul 25:1-7. doi: 10.1017/thg.2023.28. Online ahead of print.ABSTRACTThe purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of geneti...
Source: Twin Research and Human Genetics - July 25, 2023 Category: Genetics & Stem Cells Authors: Raikhan Y Tuleutayeva Assem R Makhatova Saule O Rakhyzhanova Lashyn K Zhazykbayeva Dana K Kozhakhmetova Source Type: research
Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population
Twin Res Hum Genet. 2023 Jul 25:1-7. doi: 10.1017/thg.2023.28. Online ahead of print.ABSTRACTThe purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of geneti...
Source: Twin Research and Human Genetics - July 25, 2023 Category: Genetics & Stem Cells Authors: Raikhan Y Tuleutayeva Assem R Makhatova Saule O Rakhyzhanova Lashyn K Zhazykbayeva Dana K Kozhakhmetova Source Type: research
Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population
Twin Res Hum Genet. 2023 Jul 25:1-7. doi: 10.1017/thg.2023.28. Online ahead of print.ABSTRACTThe purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of geneti...
Source: Twin Research and Human Genetics - July 25, 2023 Category: Genetics & Stem Cells Authors: Raikhan Y Tuleutayeva Assem R Makhatova Saule O Rakhyzhanova Lashyn K Zhazykbayeva Dana K Kozhakhmetova Source Type: research
Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population
Twin Res Hum Genet. 2023 Jul 25:1-7. doi: 10.1017/thg.2023.28. Online ahead of print.ABSTRACTThe purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of geneti...
Source: Twin Research and Human Genetics - July 25, 2023 Category: Genetics & Stem Cells Authors: Raikhan Y Tuleutayeva Assem R Makhatova Saule O Rakhyzhanova Lashyn K Zhazykbayeva Dana K Kozhakhmetova Source Type: research
Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population
Twin Res Hum Genet. 2023 Jul 25:1-7. doi: 10.1017/thg.2023.28. Online ahead of print.ABSTRACTThe purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of geneti...
Source: Twin Research and Human Genetics - July 25, 2023 Category: Genetics & Stem Cells Authors: Raikhan Y Tuleutayeva Assem R Makhatova Saule O Rakhyzhanova Lashyn K Zhazykbayeva Dana K Kozhakhmetova Source Type: research
Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population
Twin Res Hum Genet. 2023 Jul 25:1-7. doi: 10.1017/thg.2023.28. Online ahead of print.ABSTRACTThe purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of geneti...
Source: Twin Research and Human Genetics - July 25, 2023 Category: Genetics & Stem Cells Authors: Raikhan Y Tuleutayeva Assem R Makhatova Saule O Rakhyzhanova Lashyn K Zhazykbayeva Dana K Kozhakhmetova Source Type: research
Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population
Twin Res Hum Genet. 2023 Jul 25:1-7. doi: 10.1017/thg.2023.28. Online ahead of print.ABSTRACTThe purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of geneti...
Source: Twin Research and Human Genetics - July 25, 2023 Category: Genetics & Stem Cells Authors: Raikhan Y Tuleutayeva Assem R Makhatova Saule O Rakhyzhanova Lashyn K Zhazykbayeva Dana K Kozhakhmetova Source Type: research
Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population
Twin Res Hum Genet. 2023 Jul 25:1-7. doi: 10.1017/thg.2023.28. Online ahead of print.ABSTRACTThe purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of geneti...
Source: Twin Research and Human Genetics - July 25, 2023 Category: Genetics & Stem Cells Authors: Raikhan Y Tuleutayeva Assem R Makhatova Saule O Rakhyzhanova Lashyn K Zhazykbayeva Dana K Kozhakhmetova Source Type: research
The Effect of Genetic Predisposition to Alzheimer's Disease and Related Traits on Recruitment Bias in a Study of Cognitive Aging
Twin Res Hum Genet. 2023 Jul 21:1-6. doi: 10.1017/thg.2023.26. Online ahead of print.ABSTRACTThe recruitment of participants for research studies may be subject to bias. The Prospective Imaging Study of Ageing (PISA) aims to characterize the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). Participants approached to take part in PISA were selected from existing cohort studies with available genomewide genetic data for both successfully and unsuccessfully recruited participants, allowing us to investigate the genetic contribution to voluntary recruitment, including ...
Source: Twin Research and Human Genetics - July 21, 2023 Category: Genetics & Stem Cells Authors: Lina M Gomez Brittany L Mitchell Kerrie McAloney Jessica Adsett Natalie Garden Madeline Wood Santiago Diaz-Torres Luis M Garcia-Marin Michael Breakspear Nicholas G Martin Michelle K Lupton Source Type: research
The Effect of Genetic Predisposition to Alzheimer's Disease and Related Traits on Recruitment Bias in a Study of Cognitive Aging
Twin Res Hum Genet. 2023 Jul 21:1-6. doi: 10.1017/thg.2023.26. Online ahead of print.ABSTRACTThe recruitment of participants for research studies may be subject to bias. The Prospective Imaging Study of Ageing (PISA) aims to characterize the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). Participants approached to take part in PISA were selected from existing cohort studies with available genomewide genetic data for both successfully and unsuccessfully recruited participants, allowing us to investigate the genetic contribution to voluntary recruitment, including ...
Source: Twin Research and Human Genetics - July 21, 2023 Category: Genetics & Stem Cells Authors: Lina M Gomez Brittany L Mitchell Kerrie McAloney Jessica Adsett Natalie Garden Madeline Wood Santiago Diaz-Torres Luis M Garcia-Marin Michael Breakspear Nicholas G Martin Michelle K Lupton Source Type: research
The Effect of Genetic Predisposition to Alzheimer's Disease and Related Traits on Recruitment Bias in a Study of Cognitive Aging
Twin Res Hum Genet. 2023 Jul 21:1-6. doi: 10.1017/thg.2023.26. Online ahead of print.ABSTRACTThe recruitment of participants for research studies may be subject to bias. The Prospective Imaging Study of Ageing (PISA) aims to characterize the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). Participants approached to take part in PISA were selected from existing cohort studies with available genomewide genetic data for both successfully and unsuccessfully recruited participants, allowing us to investigate the genetic contribution to voluntary recruitment, including ...
Source: Twin Research and Human Genetics - July 21, 2023 Category: Genetics & Stem Cells Authors: Lina M Gomez Brittany L Mitchell Kerrie McAloney Jessica Adsett Natalie Garden Madeline Wood Santiago Diaz-Torres Luis M Garcia-Marin Michael Breakspear Nicholas G Martin Michelle K Lupton Source Type: research
The Effect of Genetic Predisposition to Alzheimer's Disease and Related Traits on Recruitment Bias in a Study of Cognitive Aging
Twin Res Hum Genet. 2023 Jul 21:1-6. doi: 10.1017/thg.2023.26. Online ahead of print.ABSTRACTThe recruitment of participants for research studies may be subject to bias. The Prospective Imaging Study of Ageing (PISA) aims to characterize the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). Participants approached to take part in PISA were selected from existing cohort studies with available genomewide genetic data for both successfully and unsuccessfully recruited participants, allowing us to investigate the genetic contribution to voluntary recruitment, including ...
Source: Twin Research and Human Genetics - July 21, 2023 Category: Genetics & Stem Cells Authors: Lina M Gomez Brittany L Mitchell Kerrie McAloney Jessica Adsett Natalie Garden Madeline Wood Santiago Diaz-Torres Luis M Garcia-Marin Michael Breakspear Nicholas G Martin Michelle K Lupton Source Type: research
THG volume 26 issue 2 Cover
Twin Res Hum Genet. 2023 Apr;26(2):f1. doi: 10.1017/thg.2023.30. Epub 2023 Jul 19.NO ABSTRACTPMID:37465940 | DOI:10.1017/thg.2023.30 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - July 19, 2023 Category: Genetics & Stem Cells Source Type: research
Intergenerational Transmission of BMI and Educational Outcomes in Children and Adolescents
Twin Res Hum Genet. 2023 Apr;26(2):143-151. doi: 10.1017/thg.2023.18. Epub 2023 Jul 19.ABSTRACTIndividual differences in educational attainment (EA) and physical health, as indexed by body mass index (BMI), are correlated within individuals and across generations. The aim of our study was to assess the transmission of these traits from parents to their offspring in childhood and adolescence. We analyzed BMI and EA in 13,916 families from the Netherlands. Data were available for 27,577 parents (mean age 33) and 26,855 of their offspring at 4 and 12 years of age. We employed structural equation modeling to simultaneously est...
Source: Twin Research and Human Genetics - July 19, 2023 Category: Genetics & Stem Cells Authors: Hekmat Alrouh Elsje van Bergen Conor Dolan Dorret I Boomsma Source Type: research
