Emerging programmable nuclease-based detection for food safety
Trends Biotechnol. 2023 Oct 6:S0167-7799(23)00280-9. doi: 10.1016/j.tibtech.2023.09.006. Online ahead of print.ABSTRACTFood safety issues are an important challenge across the world. Programmable nucleases are emerging as new tools because of their significant biological advantages. This forum article provides an overview of recent advances and challenges in the novel paradigm of programmable nuclease-based detection for food safety.PMID:37806898 | DOI:10.1016/j.tibtech.2023.09.006 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Yaru Li Jingyu Jia Shuli Man Shengying Ye Long Ma Source Type: research
Probiotic cultivated meat: bacterial-based scaffolds and products to improve cultivated meat
Trends Biotechnol. 2023 Oct 5:S0167-7799(23)00276-7. doi: 10.1016/j.tibtech.2023.09.002. Online ahead of print.ABSTRACTCultivated meat is emerging to replace traditional livestock industries, which have ecological costs, including land and water overuse and considerable carbon emissions. During cultivated meat production, mammalian cells can increase their numbers dramatically through self-renewal/proliferation and transform into mature cells, such as muscle or fat cells, through maturation/differentiation. Here, we address opportunities for introducing probiotic bacteria into the cultivated meat industry, including using ...
Source: Trends in Biotechnology - October 7, 2023 Category: Biotechnology Authors: Ilana Kolodkin-Gal Orit Dash Roni Rak Source Type: research
Probiotic cultivated meat: bacterial-based scaffolds and products to improve cultivated meat
Trends Biotechnol. 2023 Oct 5:S0167-7799(23)00276-7. doi: 10.1016/j.tibtech.2023.09.002. Online ahead of print.ABSTRACTCultivated meat is emerging to replace traditional livestock industries, which have ecological costs, including land and water overuse and considerable carbon emissions. During cultivated meat production, mammalian cells can increase their numbers dramatically through self-renewal/proliferation and transform into mature cells, such as muscle or fat cells, through maturation/differentiation. Here, we address opportunities for introducing probiotic bacteria into the cultivated meat industry, including using ...
Source: Trends in Biotechnology - October 7, 2023 Category: Biotechnology Authors: Ilana Kolodkin-Gal Orit Dash Roni Rak Source Type: research
Disposable rocking bioreactors: recent applications and progressive perspectives
Trends Biotechnol. 2023 Oct 3:S0167-7799(23)00277-9. doi: 10.1016/j.tibtech.2023.09.003. Online ahead of print.ABSTRACTDisposable rocking bioreactors facilitate scaling up animal and plant cell biomass propagation and developing specified bioprocesses like manufacturing vaccines or chimeric antigen receptor (CAR) T cells. Future contexts for these bioreactors include supporting regenerative medicine, recognising metabolic responses of biochemically or mechanically stressed cells, continuously performing in vitro bioprocesses, or cell-free protein synthesis systems.PMID:37798143 | DOI:10.1016/j.tibtech.2023.09.003 (Source: ...
Source: Trends in Biotechnology - October 5, 2023 Category: Biotechnology Authors: Kamil Wierzchowski Maciej Pilarek Source Type: research
The ethics of engineered living materials
This article identifies key ethical and safety issues by reflecting on fundamental ethical principles. It further discusses a future ethical roadmap for sustainable research in ELMs.PMID:37798144 | DOI:10.1016/j.tibtech.2023.09.004 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - October 5, 2023 Category: Biotechnology Authors: Mette Ebbesen Jan G Korvink Monsur Islam Andr és Díaz Lantada Source Type: research
Disposable rocking bioreactors: recent applications and progressive perspectives
Trends Biotechnol. 2023 Oct 3:S0167-7799(23)00277-9. doi: 10.1016/j.tibtech.2023.09.003. Online ahead of print.ABSTRACTDisposable rocking bioreactors facilitate scaling up animal and plant cell biomass propagation and developing specified bioprocesses like manufacturing vaccines or chimeric antigen receptor (CAR) T cells. Future contexts for these bioreactors include supporting regenerative medicine, recognising metabolic responses of biochemically or mechanically stressed cells, continuously performing in vitro bioprocesses, or cell-free protein synthesis systems.PMID:37798143 | DOI:10.1016/j.tibtech.2023.09.003 (Source: ...
Source: Trends in Biotechnology - October 5, 2023 Category: Biotechnology Authors: Kamil Wierzchowski Maciej Pilarek Source Type: research
The ethics of engineered living materials
This article identifies key ethical and safety issues by reflecting on fundamental ethical principles. It further discusses a future ethical roadmap for sustainable research in ELMs.PMID:37798144 | DOI:10.1016/j.tibtech.2023.09.004 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - October 5, 2023 Category: Biotechnology Authors: Mette Ebbesen Jan G Korvink Monsur Islam Andr és Díaz Lantada Source Type: research
Printhead on a chip: empowering droplet-based bioprinting with microfluidics
Trends Biotechnol. 2023 Sep 28:S0167-7799(23)00275-5. doi: 10.1016/j.tibtech.2023.09.001. Online ahead of print.ABSTRACTDroplet-based bioprinting has long struggled with the manipulation and dispensation of individual cells from a printhead, hindering the fabrication of artificial cellular structures with high precision. The integration of modern microfluidic modules into the printhead of a bioprinter is emerging as one approach to overcome this bottleneck. This convergence allows for high-accuracy manipulation and spatial control over placement of cells during printing, and enables the fabrication of cell arrays and hiera...
Source: Trends in Biotechnology - September 30, 2023 Category: Biotechnology Authors: Pengfei Zhang Congying Liu Cyrus Modavi Adam Abate Huawei Chen Source Type: research
Printhead on a chip: empowering droplet-based bioprinting with microfluidics
Trends Biotechnol. 2023 Sep 28:S0167-7799(23)00275-5. doi: 10.1016/j.tibtech.2023.09.001. Online ahead of print.ABSTRACTDroplet-based bioprinting has long struggled with the manipulation and dispensation of individual cells from a printhead, hindering the fabrication of artificial cellular structures with high precision. The integration of modern microfluidic modules into the printhead of a bioprinter is emerging as one approach to overcome this bottleneck. This convergence allows for high-accuracy manipulation and spatial control over placement of cells during printing, and enables the fabrication of cell arrays and hiera...
Source: Trends in Biotechnology - September 30, 2023 Category: Biotechnology Authors: Pengfei Zhang Congying Liu Cyrus Modavi Adam Abate Huawei Chen Source Type: research
Printhead on a chip: empowering droplet-based bioprinting with microfluidics
Trends Biotechnol. 2023 Sep 28:S0167-7799(23)00275-5. doi: 10.1016/j.tibtech.2023.09.001. Online ahead of print.ABSTRACTDroplet-based bioprinting has long struggled with the manipulation and dispensation of individual cells from a printhead, hindering the fabrication of artificial cellular structures with high precision. The integration of modern microfluidic modules into the printhead of a bioprinter is emerging as one approach to overcome this bottleneck. This convergence allows for high-accuracy manipulation and spatial control over placement of cells during printing, and enables the fabrication of cell arrays and hiera...
Source: Trends in Biotechnology - September 30, 2023 Category: Biotechnology Authors: Pengfei Zhang Congying Liu Cyrus Modavi Adam Abate Huawei Chen Source Type: research
Printhead on a chip: empowering droplet-based bioprinting with microfluidics
Trends Biotechnol. 2023 Sep 28:S0167-7799(23)00275-5. doi: 10.1016/j.tibtech.2023.09.001. Online ahead of print.ABSTRACTDroplet-based bioprinting has long struggled with the manipulation and dispensation of individual cells from a printhead, hindering the fabrication of artificial cellular structures with high precision. The integration of modern microfluidic modules into the printhead of a bioprinter is emerging as one approach to overcome this bottleneck. This convergence allows for high-accuracy manipulation and spatial control over placement of cells during printing, and enables the fabrication of cell arrays and hiera...
Source: Trends in Biotechnology - September 30, 2023 Category: Biotechnology Authors: Pengfei Zhang Congying Liu Cyrus Modavi Adam Abate Huawei Chen Source Type: research
Engineering functional homopolymeric amino acids: from biosynthesis to design
Trends Biotechnol. 2023 Sep 27:S0167-7799(23)00261-5. doi: 10.1016/j.tibtech.2023.08.010. Online ahead of print.ABSTRACTHomopolymeric amino acids (HPAs) are a class of microbial polymers that can be classified into two categories: anionic and cationic HPAs. Notable examples include γ-poly-glutamic acid (γ-PGA) and ε-poly-L-lysine (ε-PL) that have wide-ranging applications in medicine, food, and agriculture. The primary method of manufacture is through microbial synthesis. In recent decades significant efforts have been made to enhance the production of HPAs, specifically focusing on γ-PGA and ε-PL. We comprehensively...
Source: Trends in Biotechnology - September 29, 2023 Category: Biotechnology Authors: Yibin Qiu Delei Xu Peng Lei Sha Li Hong Xu Source Type: research
What should next-generation analytical platforms for biopharmaceutical production look like?
Trends Biotechnol. 2023 Sep 27:S0167-7799(23)00256-1. doi: 10.1016/j.tibtech.2023.08.008. Online ahead of print.ABSTRACTBiotherapeutic products, particularly complex products such as monoclonal antibodies (mAbs), have as many as 20-30 critical quality attributes (CQAs), thereby requiring a collection of orthogonal, high-resolution analytical tools for characterization and making characterization a resource-intensive task. As discussed in this Opinion, the need to reduce the cost of developing biotherapeutic products and the need to adopt Industry 4.0 and eventually Industry 5.0 paradigms are driving a reappraisal of existi...
Source: Trends in Biotechnology - September 29, 2023 Category: Biotechnology Authors: Anurag S Rathore Deepika Sarin Source Type: research
Engineering functional homopolymeric amino acids: from biosynthesis to design
Trends Biotechnol. 2023 Sep 27:S0167-7799(23)00261-5. doi: 10.1016/j.tibtech.2023.08.010. Online ahead of print.ABSTRACTHomopolymeric amino acids (HPAs) are a class of microbial polymers that can be classified into two categories: anionic and cationic HPAs. Notable examples include γ-poly-glutamic acid (γ-PGA) and ε-poly-L-lysine (ε-PL) that have wide-ranging applications in medicine, food, and agriculture. The primary method of manufacture is through microbial synthesis. In recent decades significant efforts have been made to enhance the production of HPAs, specifically focusing on γ-PGA and ε-PL. We comprehensively...
Source: Trends in Biotechnology - September 29, 2023 Category: Biotechnology Authors: Yibin Qiu Delei Xu Peng Lei Sha Li Hong Xu Source Type: research
What should next-generation analytical platforms for biopharmaceutical production look like?
Trends Biotechnol. 2023 Sep 27:S0167-7799(23)00256-1. doi: 10.1016/j.tibtech.2023.08.008. Online ahead of print.ABSTRACTBiotherapeutic products, particularly complex products such as monoclonal antibodies (mAbs), have as many as 20-30 critical quality attributes (CQAs), thereby requiring a collection of orthogonal, high-resolution analytical tools for characterization and making characterization a resource-intensive task. As discussed in this Opinion, the need to reduce the cost of developing biotherapeutic products and the need to adopt Industry 4.0 and eventually Industry 5.0 paradigms are driving a reappraisal of existi...
Source: Trends in Biotechnology - September 29, 2023 Category: Biotechnology Authors: Anurag S Rathore Deepika Sarin Source Type: research
