Making the biochemical conversion of lignocellulose more robust
Trends Biotechnol. 2023 Oct 17:S0167-7799(23)00288-3. doi: 10.1016/j.tibtech.2023.09.014. Online ahead of print.ABSTRACTLignocellulose is an alternative to fossil resources, but its biochemical conversion is not economically competitive. While decentralized processing can reduce logistical cost for this feedstock, sugar platforms need to be developed with energy-saving pretreatment technologies and cost-effective cellulases, and products must be selected correctly. Anaerobic fermentation with less energy consumption and lower contamination risk is preferred, particularly for producing biofuels. Great effort has been devote...
Source: Trends in Biotechnology - October 20, 2023 Category: Biotechnology Authors: Xin-Qing Zhao Chen-Guang Liu Feng-Wu Bai Source Type: research
Redefining biomaterial biocompatibility: challenges for artificial intelligence and text mining
Trends Biotechnol. 2023 Oct 17:S0167-7799(23)00289-5. doi: 10.1016/j.tibtech.2023.09.015. Online ahead of print.ABSTRACTThe surge in 'Big data' has significantly influenced biomaterials research and development, with vast data volumes emerging from clinical trials, scientific literature, electronic health records, and other sources. Biocompatibility is essential in developing safe medical devices and biomaterials to perform as intended without provoking adverse reactions. Therefore, establishing an artificial intelligence (AI)-driven biocompatibility definition has become decisive for automating data extraction and profili...
Source: Trends in Biotechnology - October 20, 2023 Category: Biotechnology Authors: Miguel Mateu-Sanz Carla V Fuentesl ópez Juan Uribe-Gomez H åvard Jostein Haugen Abhay Pandit Maria-Pau Ginebra Osnat Hakimi Martin Krallinger Athina Samara Source Type: research
Making the biochemical conversion of lignocellulose more robust
Trends Biotechnol. 2023 Oct 17:S0167-7799(23)00288-3. doi: 10.1016/j.tibtech.2023.09.014. Online ahead of print.ABSTRACTLignocellulose is an alternative to fossil resources, but its biochemical conversion is not economically competitive. While decentralized processing can reduce logistical cost for this feedstock, sugar platforms need to be developed with energy-saving pretreatment technologies and cost-effective cellulases, and products must be selected correctly. Anaerobic fermentation with less energy consumption and lower contamination risk is preferred, particularly for producing biofuels. Great effort has been devote...
Source: Trends in Biotechnology - October 20, 2023 Category: Biotechnology Authors: Xin-Qing Zhao Chen-Guang Liu Feng-Wu Bai Source Type: research
Redefining biomaterial biocompatibility: challenges for artificial intelligence and text mining
Trends Biotechnol. 2023 Oct 17:S0167-7799(23)00289-5. doi: 10.1016/j.tibtech.2023.09.015. Online ahead of print.ABSTRACTThe surge in 'Big data' has significantly influenced biomaterials research and development, with vast data volumes emerging from clinical trials, scientific literature, electronic health records, and other sources. Biocompatibility is essential in developing safe medical devices and biomaterials to perform as intended without provoking adverse reactions. Therefore, establishing an artificial intelligence (AI)-driven biocompatibility definition has become decisive for automating data extraction and profili...
Source: Trends in Biotechnology - October 20, 2023 Category: Biotechnology Authors: Miguel Mateu-Sanz Carla V Fuentesl ópez Juan Uribe-Gomez H åvard Jostein Haugen Abhay Pandit Maria-Pau Ginebra Osnat Hakimi Martin Krallinger Athina Samara Source Type: research
Emerging granular hydrogel bioinks to improve biological function in bioprinted constructs
Trends Biotechnol. 2023 Oct 16:S0167-7799(23)00281-0. doi: 10.1016/j.tibtech.2023.09.007. Online ahead of print.ABSTRACTAdvancements in 3D bioprinting have been hindered by the trade-off between printability and biological functionality. Existing bioinks struggle to meet both requirements simultaneously. However, new types of bioinks composed of densely packed microgels promise to address this challenge. These bioinks possess intrinsic porosity, allowing for cell growth, oxygen and nutrient transport, and better immunomodulatory properties, leading to superior biological functions. In this review, we highlight key trends i...
Source: Trends in Biotechnology - October 18, 2023 Category: Biotechnology Authors: Cody Tuftee Eben Alsberg Ibrahim Tarik Ozbolat Muhammad Rizwan Source Type: research
Biomaterials containing extracellular matrix molecules as biomimetic next-generation vascular grafts
Trends Biotechnol. 2023 Oct 16:S0167-7799(23)00283-4. doi: 10.1016/j.tibtech.2023.09.009. Online ahead of print.ABSTRACTThe performance of synthetic biomaterial vascular grafts for the bypass of stenotic and dysfunctional blood vessels remains an intractable challenge in small-diameter applications. The functionalization of biomaterials with extracellular matrix (ECM) molecules is a promising approach because these molecules can regulate multiple biological processes in vascular tissues. In this review, we critically examine emerging approaches to ECM-containing vascular graft biomaterials and explore opportunities for fut...
Source: Trends in Biotechnology - October 18, 2023 Category: Biotechnology Authors: Shouyuan Jiang Steven G Wise Jason C Kovacic Jelena Rnjak-Kovacina Megan S Lord Source Type: research
Emerging granular hydrogel bioinks to improve biological function in bioprinted constructs
Trends Biotechnol. 2023 Oct 16:S0167-7799(23)00281-0. doi: 10.1016/j.tibtech.2023.09.007. Online ahead of print.ABSTRACTAdvancements in 3D bioprinting have been hindered by the trade-off between printability and biological functionality. Existing bioinks struggle to meet both requirements simultaneously. However, new types of bioinks composed of densely packed microgels promise to address this challenge. These bioinks possess intrinsic porosity, allowing for cell growth, oxygen and nutrient transport, and better immunomodulatory properties, leading to superior biological functions. In this review, we highlight key trends i...
Source: Trends in Biotechnology - October 18, 2023 Category: Biotechnology Authors: Cody Tuftee Eben Alsberg Ibrahim Tarik Ozbolat Muhammad Rizwan Source Type: research
Biomaterials containing extracellular matrix molecules as biomimetic next-generation vascular grafts
Trends Biotechnol. 2023 Oct 16:S0167-7799(23)00283-4. doi: 10.1016/j.tibtech.2023.09.009. Online ahead of print.ABSTRACTThe performance of synthetic biomaterial vascular grafts for the bypass of stenotic and dysfunctional blood vessels remains an intractable challenge in small-diameter applications. The functionalization of biomaterials with extracellular matrix (ECM) molecules is a promising approach because these molecules can regulate multiple biological processes in vascular tissues. In this review, we critically examine emerging approaches to ECM-containing vascular graft biomaterials and explore opportunities for fut...
Source: Trends in Biotechnology - October 18, 2023 Category: Biotechnology Authors: Shouyuan Jiang Steven G Wise Jason C Kovacic Jelena Rnjak-Kovacina Megan S Lord Source Type: research
Engineering microbiomes to transform plastics
Trends Biotechnol. 2023 Oct 14:S0167-7799(23)00285-8. doi: 10.1016/j.tibtech.2023.09.011. Online ahead of print.ABSTRACTThe design and study of active microbial consortia able to degrade plastics represent an exciting area of research toward the development of bio-based alternatives to efficiently transform plastic waste. This forum article discusses concepts and mechanisms to inform emerging strategies for engineering microbiomes to transform plastics under controlled settings.PMID:37845169 | DOI:10.1016/j.tibtech.2023.09.011 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - October 16, 2023 Category: Biotechnology Authors: Diego Javier Jim énez Alvaro Sanchez Francisco Dini-Andreote Source Type: research
Engineering microbiomes to transform plastics
Trends Biotechnol. 2023 Oct 14:S0167-7799(23)00285-8. doi: 10.1016/j.tibtech.2023.09.011. Online ahead of print.ABSTRACTThe design and study of active microbial consortia able to degrade plastics represent an exciting area of research toward the development of bio-based alternatives to efficiently transform plastic waste. This forum article discusses concepts and mechanisms to inform emerging strategies for engineering microbiomes to transform plastics under controlled settings.PMID:37845169 | DOI:10.1016/j.tibtech.2023.09.011 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - October 16, 2023 Category: Biotechnology Authors: Diego Javier Jim énez Alvaro Sanchez Francisco Dini-Andreote Source Type: research
Applications of designer phage encoding recombinant gene payloads
Trends Biotechnol. 2023 Oct 11:S0167-7799(23)00282-2. doi: 10.1016/j.tibtech.2023.09.008. Online ahead of print.ABSTRACTAdvances in genetic engineering, synthetic biology, and DNA sequencing have transformed the re-emergent therapeutic bacteriophage field. The increasing rate of multidrug resistant (MDR) infections and the speed at which new bacteriophages can be isolated, sequenced, characterized, and engineered has reinvigorated phage therapy and unlocked new applications of phages for modulating bacteria. The methods used to genetically engineer bacteriophages are undergoing significant development, but identification o...
Source: Trends in Biotechnology - October 13, 2023 Category: Biotechnology Authors: Daniel S Schmitt Sara D Siegel Kurt Selle Source Type: research
Next-generation industrial biotechnology for low-cost mass production of PHA
Trends Biotechnol. 2023 Oct 11:S0167-7799(23)00287-1. doi: 10.1016/j.tibtech.2023.09.013. Online ahead of print.NO ABSTRACTPMID:37833199 | DOI:10.1016/j.tibtech.2023.09.013 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - October 13, 2023 Category: Biotechnology Authors: Xiaohan Zhang Huanyu Chen Pengfei Ouyang Xu Liu Source Type: research
Applications of designer phage encoding recombinant gene payloads
Trends Biotechnol. 2023 Oct 11:S0167-7799(23)00282-2. doi: 10.1016/j.tibtech.2023.09.008. Online ahead of print.ABSTRACTAdvances in genetic engineering, synthetic biology, and DNA sequencing have transformed the re-emergent therapeutic bacteriophage field. The increasing rate of multidrug resistant (MDR) infections and the speed at which new bacteriophages can be isolated, sequenced, characterized, and engineered has reinvigorated phage therapy and unlocked new applications of phages for modulating bacteria. The methods used to genetically engineer bacteriophages are undergoing significant development, but identification o...
Source: Trends in Biotechnology - October 13, 2023 Category: Biotechnology Authors: Daniel S Schmitt Sara D Siegel Kurt Selle Source Type: research
Next-generation industrial biotechnology for low-cost mass production of PHA
Trends Biotechnol. 2023 Oct 11:S0167-7799(23)00287-1. doi: 10.1016/j.tibtech.2023.09.013. Online ahead of print.NO ABSTRACTPMID:37833199 | DOI:10.1016/j.tibtech.2023.09.013 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - October 13, 2023 Category: Biotechnology Authors: Xiaohan Zhang Huanyu Chen Pengfei Ouyang Xu Liu Source Type: research
Applications of designer phage encoding recombinant gene payloads
Trends Biotechnol. 2023 Oct 11:S0167-7799(23)00282-2. doi: 10.1016/j.tibtech.2023.09.008. Online ahead of print.ABSTRACTAdvances in genetic engineering, synthetic biology, and DNA sequencing have transformed the re-emergent therapeutic bacteriophage field. The increasing rate of multidrug resistant (MDR) infections and the speed at which new bacteriophages can be isolated, sequenced, characterized, and engineered has reinvigorated phage therapy and unlocked new applications of phages for modulating bacteria. The methods used to genetically engineer bacteriophages are undergoing significant development, but identification o...
Source: Trends in Biotechnology - October 13, 2023 Category: Biotechnology Authors: Daniel S Schmitt Sara D Siegel Kurt Selle Source Type: research
