Killer yeasts: expanding frontiers in the age of synthetic biology
Trends Biotechnol. 2024 Apr 3:S0167-7799(24)00067-2. doi: 10.1016/j.tibtech.2024.03.003. Online ahead of print.ABSTRACTKiller yeasts secrete protein toxins that are selectively lethal to other yeast and filamentous fungi. These exhibit exceptional genetic and functional diversity, and have several biotechnological applications. However, despite decades of research, several limitations hinder their widespread adoption. In this perspective we contend that technical advances in synthetic biology present an unprecedented opportunity to unlock the full potential of yeast killer systems across a spectrum of applications. By leve...
Source: Trends in Biotechnology - April 4, 2024 Category: Biotechnology Authors: Sonja Billerbeck Roy S K Walker Isak S Pretorius Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
Anticipatory regulation for pandemic responses: are we there yet?
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00064-7. doi: 10.1016/j.tibtech.2024.02.016. Online ahead of print.ABSTRACTCan drug and vaccine regulatory agencies leverage their experience during the coronavirus disease 2019 (COVID-19) pandemic to advance from reactive regulation to adaptive regulation and beyond to anticipatory regulation to prevent or curb future pandemics?PMID:38538499 | DOI:10.1016/j.tibtech.2024.02.016 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - March 27, 2024 Category: Biotechnology Authors: Maria Giuliana Oyola-Lozada Lisette Pregelj Anna Jenkins Evan Siegel Trent Munro Damian Hine Source Type: research
Anticipatory regulation for pandemic responses: are we there yet?
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00064-7. doi: 10.1016/j.tibtech.2024.02.016. Online ahead of print.ABSTRACTCan drug and vaccine regulatory agencies leverage their experience during the coronavirus disease 2019 (COVID-19) pandemic to advance from reactive regulation to adaptive regulation and beyond to anticipatory regulation to prevent or curb future pandemics?PMID:38538499 | DOI:10.1016/j.tibtech.2024.02.016 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - March 27, 2024 Category: Biotechnology Authors: Maria Giuliana Oyola-Lozada Lisette Pregelj Anna Jenkins Evan Siegel Trent Munro Damian Hine Source Type: research
Enhancing the palatability of cultivated meat
Trends Biotechnol. 2024 Mar 26:S0167-7799(24)00062-3. doi: 10.1016/j.tibtech.2024.02.014. Online ahead of print.ABSTRACTCultivated meat (CM) has transitioned from a futuristic concept to a present reality, with select products approved for consumption and sale in Singapore, Israel, and the USA. This evolution has emphasized scalable, cost-effective, and sustainable production, as well as navigation of regulatory pathways. As CM develops, a crucial challenge lies in delivering products that are highly appealing to consumers. Central to this will be refining CM palatability, a term encompassing food's taste, aroma, texture, ...
Source: Trends in Biotechnology - March 26, 2024 Category: Biotechnology Authors: Ella G Lambert Christopher J O'Keeffe Alexander O Ward Tim A Anderson Queenie Yip Peter L H Newman Source Type: research
Enhancing the palatability of cultivated meat
Trends Biotechnol. 2024 Mar 26:S0167-7799(24)00062-3. doi: 10.1016/j.tibtech.2024.02.014. Online ahead of print.ABSTRACTCultivated meat (CM) has transitioned from a futuristic concept to a present reality, with select products approved for consumption and sale in Singapore, Israel, and the USA. This evolution has emphasized scalable, cost-effective, and sustainable production, as well as navigation of regulatory pathways. As CM develops, a crucial challenge lies in delivering products that are highly appealing to consumers. Central to this will be refining CM palatability, a term encompassing food's taste, aroma, texture, ...
Source: Trends in Biotechnology - March 26, 2024 Category: Biotechnology Authors: Ella G Lambert Christopher J O'Keeffe Alexander O Ward Tim A Anderson Queenie Yip Peter L H Newman Source Type: research
Emerging biotechnological applications of anaerobic ammonium oxidation
Trends Biotechnol. 2024 Mar 21:S0167-7799(24)00061-1. doi: 10.1016/j.tibtech.2024.02.013. Online ahead of print.ABSTRACTAnaerobic ammonium oxidation (anammox) is an energy-efficient method for nitrogen removal that opens the possibility for energy-neutral wastewater treatment. Research on anammox over the past decade has primarily focused on its implementation in domestic wastewater treatment. However, emerging studies are now expanding its use to novel biotechnological applications and wastewater treatment processes. This review highlights recent advances in the anammox field that aim to overcome conventional bottlenecks,...
Source: Trends in Biotechnology - March 22, 2024 Category: Biotechnology Authors: Dario Rangel Shaw Julian Tobon Gonzalez Carlos Bibiano Guadarrama Pascal E Saikaly Source Type: research
Emerging biotechnological applications of anaerobic ammonium oxidation
Trends Biotechnol. 2024 Mar 21:S0167-7799(24)00061-1. doi: 10.1016/j.tibtech.2024.02.013. Online ahead of print.ABSTRACTAnaerobic ammonium oxidation (anammox) is an energy-efficient method for nitrogen removal that opens the possibility for energy-neutral wastewater treatment. Research on anammox over the past decade has primarily focused on its implementation in domestic wastewater treatment. However, emerging studies are now expanding its use to novel biotechnological applications and wastewater treatment processes. This review highlights recent advances in the anammox field that aim to overcome conventional bottlenecks,...
Source: Trends in Biotechnology - March 22, 2024 Category: Biotechnology Authors: Dario Rangel Shaw Julian Tobon Gonzalez Carlos Bibiano Guadarrama Pascal E Saikaly Source Type: research
Emerging biotechnological applications of anaerobic ammonium oxidation
Trends Biotechnol. 2024 Mar 21:S0167-7799(24)00061-1. doi: 10.1016/j.tibtech.2024.02.013. Online ahead of print.ABSTRACTAnaerobic ammonium oxidation (anammox) is an energy-efficient method for nitrogen removal that opens the possibility for energy-neutral wastewater treatment. Research on anammox over the past decade has primarily focused on its implementation in domestic wastewater treatment. However, emerging studies are now expanding its use to novel biotechnological applications and wastewater treatment processes. This review highlights recent advances in the anammox field that aim to overcome conventional bottlenecks,...
Source: Trends in Biotechnology - March 22, 2024 Category: Biotechnology Authors: Dario Rangel Shaw Julian Tobon Gonzalez Carlos Bibiano Guadarrama Pascal E Saikaly Source Type: research
Mini-bones: miniaturized bone in vitro models
Trends Biotechnol. 2024 Mar 15:S0167-7799(24)00004-0. doi: 10.1016/j.tibtech.2024.01.004. Online ahead of print.ABSTRACTIn bone tissue engineering (TE) and regeneration, miniaturized, (sub)millimeter-sized bone models have become a popular trend since they bring about physiological biomimicry, precise orchestration of concurrent stimuli, and compatibility with high-throughput setups and high-content imaging. They also allow efficient use of cells, reagents, materials, and energy. In this review, we describe the state of the art of miniaturized in vitro bone models, or 'mini-bones', describing these models based on their ch...
Source: Trends in Biotechnology - March 16, 2024 Category: Biotechnology Authors: Maria Gabriella Fois Martijn van Griensven Stefan Giselbrecht Pamela Habibovi ć Roman K Truckenm üller Zeinab Niloofar Tahmasebi Birgani Source Type: research
