Correction to: Is the Human Touch Always Therapeutic? Patient Stimulation and Spreading Depolarization after Acute Neurological Injuries
(Source: Translational Stroke Research)
Source: Translational Stroke Research - May 19, 2022 Category: Neurology Source Type: research
The Unconventional Growth Factors Cerebral Dopamine Neurotrophic Factor and Mesencephalic Astrocyte –Derived Neurotrophic Factor Promote Post-ischemic Neurological Recovery, Perilesional Brain Remodeling, and Lesion-Remote Axonal Plasticity
AbstractConsiderable efforts are currently made to develop strategies that boost endogenous recovery once a stroke has occurred. Owing to their restorative properties, neurotrophic factors are attractive candidates that capitalize on endogenous response mechanisms. Non-conventional growth factors cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) promote neuronal survival and reduce neurological deficits in the acute phase of ischemic stroke in mice. Their effects on endogenous repair and recovery mechanisms in the stroke recovery phase were so far unknown. By intrac...
Source: Translational Stroke Research - May 18, 2022 Category: Neurology Source Type: research
A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score
This study aimed to establish a new scoring model based on the early brain injury (EBI) indicators to predict the 90-day functional outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). We retrospectively enrolled 825 patients and prospectively enrolled 108 patients with aSAH who underwent surgical clipping or endovascular coiling (derivation cohort  = 640; validation cohort = 185; prospective cohort = 108) in our institute. We established a logistic regression model based on independent risk factors associated with 90-day unfavorable outcomes. The discrimination of the prognostic model was asses...
Source: Translational Stroke Research - May 14, 2022 Category: Neurology Source Type: research
Iron-Induced Hydrocephalus: the Role of Choroid Plexus Stromal Macrophages
In conclusion, stromal macrophages account for ~10% of all choroid plexus cells, with more in aged rats. Treatments targeting macrophages (minocycline and clodronate liposomes) are associated with reduced iron-induced hydrocephalus. (Source: Translational Stroke Research)
Source: Translational Stroke Research - May 11, 2022 Category: Neurology Source Type: research
Major Caveats Discovered in the Genetic Cell Ablation Model Used to Study Microglia Functions
(Source: Translational Stroke Research)
Source: Translational Stroke Research - May 10, 2022 Category: Neurology Source Type: research
Unpacking the Role of Extracellular Vesicles in Ischemic and Hemorrhagic Stroke: Pathophysiology and Therapeutic Implications
AbstractStroke is a leading cause of death and disability worldwide. Inflammation and microvascular dysfunction have been associated with brain injury and long-term disability after both ischemic and hemorrhagic stroke. Recent studies have suggested a potential role of extracellular vesicles (EVs) as a link underlying these pathogenic processes. EVs are cell-derived particles enveloped by a lipid bilayer, containing proteins, lipids, and nucleic acids. From a functional standpoint, EVs can facilitate intercellular communication, including across the blood –brain barrier (BBB). Recent advances in EV research have shown a ...
Source: Translational Stroke Research - May 6, 2022 Category: Neurology Source Type: research
Letter to the Relationship of Morphological-Hemodynamic Characteristics, Inflammation, and Remodeling of Aneurysm Wall in Unruptured Intracranial Aneurysms
(Source: Translational Stroke Research)
Source: Translational Stroke Research - May 4, 2022 Category: Neurology Source Type: research
Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke: A Phase IIa Randomized Clinical Trial
AbstractRecombinant human prourokinase (rhPro-UK) is a novel thrombolytic that has been approved to treat patients with acute myocardial infarction. However, the safety and efficacy of intravenous rhPro-UK in patients with acute ischemic stroke (AIS) has not been well established. We aimed to investigate the safety and preliminary efficacy of rhPro-UK in patients with AIS in a multi-center phase IIa trial setting. One hundred nineteen patients within 4.5  h of AIS onset were enrolled in this randomized, open-label, 23-center phase IIa clinical trial. Patients were randomly assigned to 35 mg (n = 40) or 50 mg (n =â...
Source: Translational Stroke Research - May 3, 2022 Category: Neurology Source Type: research
Vasospasm and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: Recent Advances and Future Directions in Translational Research
(Source: Translational Stroke Research)
Source: Translational Stroke Research - May 2, 2022 Category: Neurology Source Type: research
Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant
This study identifies and characterizes a specific member of the miR-17 –92 cluster, miR-20a-3p, as a possible stroke therapeutic. A comprehensive microRNA screening showed that miR-20a-3p was significantly upregulated in astrocytes of adult female rats, which typically have better stroke outcomes, while it was profoundly downregulated in astrocytes of middle-aged fem ales and adult and middle-aged males, groups that typically have more severe stroke outcomes. Assays using primary human astrocytes and neurons show that miR-20a-3p treatment alters mitochondrial dynamics in both cell types. To assess whether stroke outcome...
Source: Translational Stroke Research - April 27, 2022 Category: Neurology Source Type: research
The Two Faces of Estrogen in Experimental Hemorrhagic Stroke
(Source: Translational Stroke Research)
Source: Translational Stroke Research - April 27, 2022 Category: Neurology Source Type: research
Drug-Coated Balloon Treatment for Delayed Recanalization of Symptomatic Intracranial Artery Occlusion
AbstractPatients with medically refractory non-acute intracranial artery occlusion (ICAO) are difficult to treat. The optimal intervention for these patients is not known. We evaluated the feasibility and safety of drug-coated balloon (DCB) treatment for non-acute ICAO. Consecutive patients with symptomatic medically refractory atherosclerotic non-acute ICAO from January 2015 to July 2021 who underwent DCB treatment were retrospectively analyzed. The rates of stroke, transient ischemic attack, and death within 30 Â days and the follow-up results were evaluated. A total of 148 patients were enrolled in this study. The 30-da...
Source: Translational Stroke Research - April 23, 2022 Category: Neurology Source Type: research
Optical Coherence Tomography in Cerebrovascular Disease: Open up New Horizons
In this study, we summarized the applications of OCT in the diagnosis, treatment, and follow-up of cerebrovascular diseases, especially in ICAS and IAs. The current limitations and future directions of OCT in the endovascular treatment of cerebrovascular disease s were also discussed. (Source: Translational Stroke Research)
Source: Translational Stroke Research - April 21, 2022 Category: Neurology Source Type: research
Heliox Preconditioning Exerts Neuroprotective Effects on Neonatal Ischemia/Hypoxia Injury by Inhibiting Necroptosis Induced by Ca2+ Elevation
In conclusion, our results suggest HePC may alleviate cytoplasmic Ca2+ overload by regulating p-RyR2, which inhibits the necroptosis in the brain, exerting neuroprotective effects on HIE. (Source: Translational Stroke Research)
Source: Translational Stroke Research - April 20, 2022 Category: Neurology Source Type: research
Intravital Imaging Reveals the Ameliorating Effect of Colchicine in a Photothrombotic Stroke Model via Inhibition of Neutrophil Recruitment
In conclusion, we have established an intravital strategy to directly investigate pathophysiology in the ischemic border zone, and found that colchicine administration in the acute phase of ischemic stroke is a potential novel therapeutic strategy. (Source: Translational Stroke Research)
Source: Translational Stroke Research - April 20, 2022 Category: Neurology Source Type: research
