Medical and Endovascular Treatments for Intracranial Atherosclerotic Stenosis: A Network Meta-Analysis
AbstractMedical treatment and endovascular therapy are widely used for intracranial atherosclerotic stenosis, but the best treatment strategy remains uncertain. The goal of this study was to compare the safety and effectiveness of medical treatment, stenting, and primary balloon angioplasty (PBA). We searched PubMed, MEDLINE, and EMBASE for trials comparing these three treatments for intracranial stenosis up to December 24, 2020. We performed a network meta-analysis with random-effects models. The primary outcome was any stroke or death during a long-term follow-up. Secondary outcomes included ischemic stroke, intracranial...
Source: Translational Stroke Research - November 18, 2021 Category: Neurology Source Type: research
Contribution of Endoplasmic Reticulum Stress to the Clinical Instability of Carotid Plaques in Human Carotid Stenosis
AbstractEndoplasmic reticulum (ER) stress is an important process during the progression of atherosclerosis. The aim of this study was to elucidate the association of ER stress and clinical instability of carotid plaque. One hundred ninety-three patients with carotid stenosis undergoing carotid endarterectomies (CEAs) were enrolled. We classified the patients into 3 groups: the asymptomatic, symptomatic, and cTIA (crescendo transient ischemic attack)/SIE (stroke in evolution) groups. Immunohistological staining was performed to assess ER stress and apoptosis. The correlation between ER stress marker expression and clinical...
Source: Translational Stroke Research - November 16, 2021 Category: Neurology Source Type: research
Response to Letter to Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy
(Source: Translational Stroke Research)
Source: Translational Stroke Research - November 15, 2021 Category: Neurology Source Type: research
Correction to: Extracellular Vesicles Derived from Neural Progenitor Cells ––a Preclinical Evaluation for Stroke Treatment in Mice
(Source: Translational Stroke Research)
Source: Translational Stroke Research - November 9, 2021 Category: Neurology Source Type: research
Mitochondrial-Based Therapeutic Strategies for Intracerebral Hemorrhage
(Source: Translational Stroke Research)
Source: Translational Stroke Research - November 6, 2021 Category: Neurology Source Type: research
