A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score

This study aimed to establish a new scoring model based on the early brain injury (EBI) indicators to predict the 90-day functional outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). We retrospectively enrolled 825 patients and prospectively enrolled 108 patients with aSAH who underwent surgical clipping or endovascular coiling (derivation cohort  = 640; validation cohort = 185; prospective cohort = 108) in our institute. We established a logistic regression model based on independent risk factors associated with 90-day unfavorable outcomes. The discrimination of the prognostic model was assessed by the area under the curve in a receiver operating characteristic curve analysis. The Hosmer–Lemeshow goodness-of-fit test and a calibration plot were used to evaluate the calibration of the prediction model. The developed scoring model named “TAPS” (total score, 0–7 points) included the following admission variables: age >  55 years old, WFNS grade of 4–5, mFS grade of 3–4, Graeb score of 5–12, white blood cell count >  11.28 × 109/L, and surgical clipping. The model showed good discrimination with the area under the curve in the derivation, validation, and prospective cohorts which were 0.816 (p <  0.001, 95%CI = 0.77–0.86), 0.810 (p <  0.001, 95%CI = 0.73–0.90), and 0.803 (p <  0.001, 95%CI = 0.70–0.91), respectively. The model also demonstrated good calibration (Hosmer–Lemesh...
Source: Translational Stroke Research - Category: Neurology Source Type: research