Real ‐world treatment patterns and clinical outcomes after introduction of immune checkpoint inhibitors: Results from a retrospective chart review of patients with advanced/metastatic non‐small cell lung cancer in the EU5
ConclusionsThis study demonstrated differences in treatment patterns and clinical outcomes in NSCLC across the EU5 and patient subgroups. Improved survival was generally associated with response to first-line therapy, nonsquamous histology, and CNS/brain metastases absence. These real-world data provide valuable insights which may aid treatment decision-making and clinical trial design. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 18, 2023 Category: Cancer & Oncology Authors: Alexander Slowley,
Kelesitse Phiri,
Jasjit K. Multani,
Vicky Casey,
Sheila Mpima,
Marie Yasuda,
Chi ‐Chang Chen,
Fil Manuguid,
Jessica Chao,
Amine Aziez,
Kelly F. Bell,
Alexander Stojadinovic Tags: ORIGINAL ARTICLE Source Type: research
Phase II trial of daily S ‐1 combined with weekly irinotecan in previously treated patients with advanced or recurrent squamous cell lung cancer: North Japan lung cancer group 1101
ConclusionsAlthough the treatment-related adverse events were manageable, the combination of weekly irinotecan and S-1 did not have the expected effect. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 17, 2023 Category: Cancer & Oncology Authors: Yosuke Kawashima,
Osamu Ishimoto,
Eisaku Miyauchi,
Tomohiro Sakakibara,
Toshiyuki Harada,
Kazuhiro Usui,
Akira Inoue,
Shunichi Sugawara Tags: ORIGINAL ARTICLE Source Type: research
Breviscapine reverses doxorubicin resistance in breast cancer and its related mechanisms
ConclusionBRE could increase the MD sensitivity to Dox via increasing Bax and cleaved-caspase-3 expression and inhibiting Bcl-2 expression, thereby promoting cell apoptosis. BRE reversed Dox resistance of MD cells by increasing Dox intracellular accumulation through inhibiting P-gp expression via EGFR. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 17, 2023 Category: Cancer & Oncology Authors: Weijiang Fu,
Jie Song,
Haiying Li Tags: ORIGINAL ARTICLE Source Type: research
Strategies to reduce morbidity following pleurectomy and decortication for malignant pleural mesothelioma
DiscussionPatients undergoing tracheostomy creation, therapeutic AC at the time of diagnosis, and gastrostomy tube placement had a reduced risk of aspiration PNA, DVT, and catheter sepsis. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 14, 2023 Category: Cancer & Oncology Authors: Patrick Bou ‐Samra,
Austin Chang,
Kevin Zhang,
Feredun Azari,
Gregory Kennedy,
Emily Guo,
Wei‐Ting Hwang,
Sunil Singhal Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Thoracic Cancer)
Source: Thoracic Cancer - August 14, 2023 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research
Survival analysis of surgical versus nonsurgical treatment in stage I to III small cell lung cancer in the last 20 years: A systematic review and meta‐analysis
AbstractMore and more patients with small cell lung cancer (SCLC) have received surgical treatment in the last 20 years. This meta-analysis compared whether surgical treatment can bring greater survival benefits to patients with stage I–III SCLC compared with chemotherapy, radiotherapy and chemoradiotherapy. Pubmed, Embase, Web of Science, Cochrane library database, and ClinicalTrials were searched for rel evant articles. The main outcomes were overall survival (OS), reported as hazard ratios (HRs), and 95% confidence intervals (CIs). A total of 19 articles containing 30 185 patients (3940 patients receiving surgica...
Source: Thoracic Cancer - August 12, 2023 Category: Cancer & Oncology Authors: Zhijian Liang,
Xiaoqi Li,
Xiao Li Tags: REVIEW Source Type: research
Healthcare utilization of lung cancer patients associated with exposure to fine particulate matter: A Korean cohort study
ConclusionsThis study suggests that exposure to PM2.5 is significantly associated with hospital utilization and drug prescription in lung cancer patients. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 12, 2023 Category: Cancer & Oncology Authors: In ‐Jae Oh,
Cheol‐Kyu Park,
Kyoung‐Bok Min,
Jin‐Young Min,
Chaeuk Chung,
Seong‐Hoon Yoon,
Changsoo Kim,
Sei‐Hoon Yang Tags: ORIGINAL ARTICLE Source Type: research
Intraoperative control of air leak using a sutureless free pericardial fat pad covering method in lung cancer resection
This study reveals the efficacy and efficiency of our method. AbstractHere, we introduce a new method for intraoperative control of air leak using a free pericardial fat pad covering to lung damage with sutureless fixation. We covered the damaged lung tissue with a free pericardial fat pad with a polyglycol acid sheet and fibrin glue fixation. This method provides a good air leak controlling effect with the use of a free pericardial fat pad and relatively short operative time with sutureless fixation. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 11, 2023 Category: Cancer & Oncology Authors: Sachie Koike,
Nobutaka Kobayashi,
Masahisa Miyazawa Tags: TECHNICAL NOTE Source Type: research
Improved survival in patients with isolated liver metastasis at initial diagnosis with surgery at primary and metastatic sites: A population ‐based study in patients with breast cancer
ConclusionSurgery at the primary and metastatic sites was associated with better survival in patients with BCILM. HER2+ patients with BCILM had a significantly better prognosis than HER2− patients. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 10, 2023 Category: Cancer & Oncology Authors: Yue Chai,
Yujie Chen,
Jiaxuan Liu,
Maiyue He,
Mingxia Jiang,
Binghe Xu,
Qiao Li Tags: ORIGINAL ARTICLE Source Type: research
One ‐way endobronchial valves in the management of complex persistent air leaks in a soft tissue sarcoma patient
A chest computed tomography (CT) scan showed the presence of an alveolopleural fistula within the right side due to the presence of persistent air leaks. After valve insertion within right upper lobe, chest CT scan showed re-expansion of the lung with obliteration of the pleural cavity. AbstractComplex persistent air leak (PAL) is a clinical condition which is difficult to treat. Herein, we report the clinical case of an 18-year-old woman with lung and bone metastases due an ultrarare sarcoma: “round cell sarcoma non-Ewing”. She developed persistent air leaks due to an alveolopleural fistula which developed following t...
Source: Thoracic Cancer - August 9, 2023 Category: Cancer & Oncology Authors: Alfonso Fiorelli,
Lucia Cannella,
Francesca Capasso,
Antonio Pizzolorusso,
Feranda Picozzi,
Gaetana Messina,
Giovanni Natale,
Edoardo Mercadante,
Salvatore Tafuto Tags: CASE REPORT Source Type: research
Integrating subvolume dose and myocardial perfusion imaging parameters to assess the impact of radiation therapy on heart function in breast cancer patients: A comparative analysis between left ‐ and right‐sided breast cancer
ConclusionThis study demonstrates an innovative integrated method combining the left ventricular 20 regional doses with SPECT MPI which shows that left-sided breast cancer patients receive a higher subvolume dose than right-sided breast cancer patients. Further research is needed to confirm the potential impact on heart function after radiotherapy on both sides. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 9, 2023 Category: Cancer & Oncology Authors: Shan ‐Ying Wang,
Wei‐Ta Tsai,
Kuan‐Heng Lin,
Chih‐Wei Yu,
Shu‐Ya Yang,
Pei‐Wei Shueng,
Yen‐Wen Wu,
Chen‐Xiong Hsu,
Tung‐Hsin Wu Tags: ORIGINAL ARTICLE Source Type: research
Treatment and mortality risk of older adults with non ‐small cell cancer in Taiwan: A population‐based cohort study
ConclusionElderly patients with NSCLC had significantly decreased mortality risk when receiving curative or palliative treatment compared with those without treatment. In the future, further studies are warranted to investigate complications and quality of life of elderly patients with NSCLC during palliative or curative treatment. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 8, 2023 Category: Cancer & Oncology Authors: Chun ‐Chieh Wang,
Shao‐Wen Chiu,
Shang‐Jung Wu,
Lung‐Kwang Pan,
Yung‐Feng Yen,
Yun‐Ju Lai,
Chu‐Chieh Chen Tags: ORIGINAL ARTICLE Source Type: research
Efficacy and safety of immune checkpoint inhibitor rechallenge in non ‐small cell lung cancer: A systematic review and meta‐analysis
ConclusionsICI rechallenge is a useful therapeutic strategy for NSCLC patients, especially suitable for those who achieve long-term tumor remission for more than 2-years under 1L-ICIs. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 8, 2023 Category: Cancer & Oncology Authors: Yu Feng,
Yunxia Tao,
Haizhu Chen,
Yu Zhou,
Le Tang,
Chenwei Liu,
Xingsheng Hu,
Yuankai Shi Tags: REVIEW Source Type: research
Correlations between class I glucose transporter expression patterns and clinical outcomes in non ‐small cell lung cancer
ConclusionsIn lung ADC, singleSLC2A3 expression correlated with poor prognosis, whereas singleSLC2A4 expression correlated with better prognosis and lowerIL8 expression. GLUT3 expression, which is increased by IL8 overexpression, may be suppressed by increasing the expression of GLUT4 through decreased IL8 expression. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 8, 2023 Category: Cancer & Oncology Authors: Yoko Nakanishi,
Momoko Iwai,
Yukari Hirotani,
Ren Kato,
Tomoyuki Tanino,
Haruna Nishimaki ‐watanabe,
Fumi Nozaki,
Sumie Ohni,
Xiaoyan Tang,
Shinobu Masuda,
Kayoko Sasaki‐fukatsu Tags: ORIGINAL ARTICLE Source Type: research
SETD1A ‐mediated H3K4me3 methylation upregulates lncRNA HOXC‐AS3 and the binding of HOXC‐AS3 to EP300 and increases EP300 stability to suppress the ferroptosis of NSCLC cells
ConclusionSETD1A-mediated H3K4me2 methylation promoted HOXC-AS3 expression, binding of HOXC-AS3 to EP300, and EP300 stability, thereby suppressing NSCLC cell ferroptosis. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 7, 2023 Category: Cancer & Oncology Authors: Zhenliang Shi,
Hao Zhang,
Yimeng Shen,
Sipei Zhang,
Xun Zhang,
Yijun Xu,
Daqiang Sun Tags: ORIGINAL ARTICLE Source Type: research
