Breviscapine reverses doxorubicin resistance in breast cancer and its related mechanisms

ConclusionBRE could increase the MD sensitivity to Dox via increasing Bax and cleaved-caspase-3 expression and inhibiting Bcl-2 expression, thereby promoting cell apoptosis. BRE reversed Dox resistance of MD cells by increasing Dox intracellular accumulation through inhibiting P-gp expression via EGFR.

Source: Thoracic Cancer - August 17, 2023 Category: Cancer & Oncology Authors: Weijiang Fu, Jie Song, Haiying Li Tags: ORIGINAL ARTICLE Source Type: research