Quantification of diffuse parenchymal lung disease in non ‐small cell lung cancer patients with definitive concurrent chemoradiation therapy for predicting radiation pneumonitis
ConclusionQuantified imaging features of DPLD obtained from pretreatment CT scans would predict the occurrence of RP in NSCLC patients undergoing definitive CCRT. Combining imaging features with clinical factors could improve the accuracy of the predictive model for severe RP. (Source: Thoracic Cancer)
Source: Thoracic Cancer - November 13, 2023 Category: Cancer & Oncology Authors: Ye Chan An,
Jong Hoon Kim,
Jae Myung Noh,
Kyung Mi Yang,
You Jin Oh,
Sung Goo Park,
Hong Ryul Pyo,
Ho Yun Lee Tags: ORIGINAL ARTICLE Source Type: research
DARS2 promotes the occurrence of lung adenocarcinoma via the ERK/c ‐Myc signaling pathway
ConclusionOur data revealed the oncogenic role of DARS2 in LUAD, indicating that DARS2 may be a predictive biomarker and novel therapeutic target for LUAD. (Source: Thoracic Cancer)
Source: Thoracic Cancer - November 11, 2023 Category: Cancer & Oncology Authors: Tao Fang,
Jin Jiang,
Wenhao Yu,
Rongyang Li,
Hui Tian Tags: ORIGINAL ARTICLE Source Type: research
Effect of chemotherapy on urinary volatile biomarkers for lung cancer by HS ‐SPME‐GC‐MS and chemometrics
ConclusionsChemotherapy administered to patients with advanced lung adenocarcinoma modified the volatile profile of urine. 2-Pentanone, a final product of the increased rate of fatty acid oxidation and protein hypermetabolism, significantly decreased after chemotherapy. Therefore, monitoring its urinary excretion could be very useful since its decrease over time could indicate an adequate response to chemotherapy and arrest of cancer development. Another VOC that could be a potential lung cancer biomarker is 3 hydroxy-2,4,4-trimethylpentyl-2-methylpropanoate, whose origin may be due to inhibition of the propanoic acid meta...
Source: Thoracic Cancer - November 10, 2023 Category: Cancer & Oncology Authors: Ricardo Rubio ‐Sánchez,
Rocío Ríos‐Reina,
Cristina Ubeda Tags: ORIGINAL ARTICLE Source Type: research
Secular trends of morbidity and mortality of thyroid cancer in five Asian countries from 1990 to 2019 and their predictions to 2035
ConclusionThe disease burden caused by TC will further increase in five Asian countries, especially for men. It is necessary to develop more rational and timely disease prevention and manage strategies facing this disease trend. (Source: Thoracic Cancer)
Source: Thoracic Cancer - November 9, 2023 Category: Cancer & Oncology Authors: Shi ‐Di Tang,
Hao Zi,
Hua Tao,
Qiao Huang,
Xing‐Pei Guo,
Tong Deng,
Fei Li Tags: ORIGINAL ARTICLE Source Type: research
Correction to “Circ‐PDZD8 promotes cell growth and glutamine metabolism in non‐small cell lung cancer by enriching LARP1 via sequestering miR‐330‐5p”
(Source: Thoracic Cancer)
Source: Thoracic Cancer - November 8, 2023 Category: Cancer & Oncology Tags: CORRECTION Source Type: research
Efficacy of everolimus ‐based therapy in advanced triple‐positive breast cancer: Experience from three cancer centers in China
ConclusionEverolimus as frontline treatment achieves clinical benefits for Chinese patients with mTPBC, which may provide some references for the management of Chinese mTPBC patients. (Source: Thoracic Cancer)
Source: Thoracic Cancer - November 8, 2023 Category: Cancer & Oncology Authors: Yujing Tan,
Hanfang Jiang,
Fei Ma,
Jiayu Wang,
Pin Zhang,
Qing Li,
Xinzhu Tian,
Binghe Xu,
Weihong Zhao,
Ying Fan Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Thoracic Cancer)
Source: Thoracic Cancer - November 6, 2023 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research
TIM ‐3 expression induces resistance to PD‐1 inhibitor in G‐CSF‐producing lung spindle cell carcinoma: A case report
In G-CSF producing lung spindle cell carcinoma, oversecreted G-CSF encourages M2 macrophages and Tim-3+ macrophages to proliferate, which may represent a new resistance mechanism to PD-1/PD-L1 inhibitors. AbstractLung spindle cell carcinoma is an aggressive subtype of pleomorphic lung cancer resistant to cytotoxic chemotherapy. Programmed cell death-1 (PD-1) inhibitors have been reported to have clinical effects in patients with spindle cell carcinoma; however, the resistance mechanism to PD-1 inhibitors is yet to be fully elucidated. Herein, we report the case of an 88-year-old man with G-CSF-producing spindle cell carcin...
Source: Thoracic Cancer - November 6, 2023 Category: Cancer & Oncology Authors: Fumiko Hayashi,
Kazumasa Akagi,
Hirokazu Taniguchi,
Toyoshi Matsutake,
Hiromi Kawahara,
Ichiro Sekine,
Hiroshi Gyotoku,
Shinnosuke Takemoto,
Hiroshi Soda,
Kazuto Ashizawa,
Hiroshi Mukae Tags: CASE REPORT Source Type: research
Miliary brain metastases from lung adenocarcinoma with EGFR (L858R) and CTNNB1 mutations
In conclusion, co-mutations of EGFR (L858R) and CTNNB1 and the discontinuation of EGFR-tyrosine kinase inhibitor may contribute to the development of miliary brain metastases. Further case studies are warranted. (Source: Thoracic Cancer)
Source: Thoracic Cancer - November 4, 2023 Category: Cancer & Oncology Authors: Michihiro Kunishige,
Eiji Takeuchi Tags: CASE IMAGE Source Type: research
Trajectories and risk factors of persistent cough after pulmonary resection: A prospective two ‐center study
ConclusionPatients who suffer from persistent CAP face a substantial burden and diminished QOL for an extended period compared to noncough patients. Moreover, prolonged duration of anesthesia and postoperative GER are potential risk factors of persistent CAP. (Source: Thoracic Cancer)
Source: Thoracic Cancer - November 3, 2023 Category: Cancer & Oncology Authors: Xuefeng Sun,
Zihua Lan,
Shaopeng Li,
Shujie Huang,
Cheng Zeng,
Junhan Wu,
Qibin Chen,
Yizhang Chen,
Ziguo Chen,
Yong Tang,
Guibin Qiao Tags: ORIGINAL ARTICLE Source Type: research
Successful management of postoperative tracheal metastasis in small cell lung cancer with radiotherapy and durvalumab: A case report
At 27 months after right lower lobectomy and lymphadenoctomy, tracheal metastasis was identified. Four months after irradiation and administration of duralumab, the nodule had vanished and normal mucosa could be observed. At 49 months after surgery, a nodule in the subglottic space was discovered. As of 61 months after surgery, the patient is reccurence free since the second course of radiotherapy. AbstractThe patient in this report was a 73-year-old male who was diagnosed with small cell lung cancer (T3N0M0 stage IIB) after presenting with a 5.5 cm tumor detected in the right lower lobe of the lung by radiograph...
Source: Thoracic Cancer - November 3, 2023 Category: Cancer & Oncology Authors: Yasoo Sugiura,
Hiroyuki Fujimoto,
Toshinori Hashizume Tags: CASE REPORT Source Type: research
Circ_0004140 promotes lung adenocarcinoma progression by upregulating NOVA2 via sponging miR ‐330‐5p
ConclusionCirc_0004140 knockdown might suppress the malignant biological behaviors of lung adenocarcinoma cells via miR-330-5p-dependent regulation of NOVA2. (Source: Thoracic Cancer)
Source: Thoracic Cancer - November 3, 2023 Category: Cancer & Oncology Authors: Fan Xia,
Mei Xie,
Jinqi He,
Deyun Cheng Tags: ORIGINAL ARTICLE Source Type: research
Nomogram based on multiparametric analysis of early ‐stage breast cancer: Prediction of high burden metastatic axillary lymph nodes
ConclusionA well-discriminated nomogram was developed to predict the high burden mALN in early-stage breast patients, which may assist the breast surgeon in choosing the appropriate surgical approach. (Source: Thoracic Cancer)
Source: Thoracic Cancer - November 3, 2023 Category: Cancer & Oncology Authors: Ling Li,
Jing Zhao,
Yu Zhang,
Zhanyu Pan,
Jin Zhang Tags: ORIGINAL ARTICLE Source Type: research
Recent advances in neoantigen vaccines for treating non ‐small cell lung cancer
In our institute, two strategies for identifying individual-specific new antigens were established and compared in patients with advanced solid tumors, including lung cancer. In the first strategy, second-generation sequencing of somatic mutations was conducted for each patient, followed by prediction for potential high-affinity mutant epitopes. In the second strategy, a shared library of neoantigen peptides was constructed. Twenty-one mutated genes were selected with a mutation frequency of>10% in solid tumors from the COSMIC database and were further analyzed in 2430 solid tumor sequencing samples from the TCGA databa...
Source: Thoracic Cancer - November 1, 2023 Category: Cancer & Oncology Authors: Shu Su,
Fungjun Chen,
Mingyuan Xu,
Baorui Liu,
Lifeng Wang Tags: MINI REVIEW Source Type: research
Correction to “Thoracic mesenchymal malignant tumors and programed cell death ligand‐1 status: Clinicopathologic and prognostic analysis of eight pulmonary sarcomatoid carcinomas and eight malignant mesotheliomas”
(Source: Thoracic Cancer)
Source: Thoracic Cancer - October 26, 2023 Category: Cancer & Oncology Tags: CORRECTION Source Type: research
