SETD1A ‐mediated H3K4me3 methylation upregulates lncRNA HOXC‐AS3 and the binding of HOXC‐AS3 to EP300 and increases EP300 stability to suppress the ferroptosis of NSCLC cells

ConclusionSETD1A-mediated H3K4me2 methylation promoted HOXC-AS3 expression, binding of HOXC-AS3 to EP300, and EP300 stability, thereby suppressing NSCLC cell ferroptosis.

Source: Thoracic Cancer - August 7, 2023 Category: Cancer & Oncology Authors: Zhenliang Shi, Hao Zhang, Yimeng Shen, Sipei Zhang, Xun Zhang, Yijun Xu, Daqiang Sun Tags: ORIGINAL ARTICLE Source Type: research