Gut microbiome affects the response to immunotherapy in non ‐small cell lung cancer
ConclusionThe findings of the present study indicated that the diversity of gut microbiota and SCFAs is related to the efficacy of immunotherapy. FMT can effectively delay tumor progression, and enhance the effect of immunotherapy, thus providing evidence for improving the efficacy of immunotherapy in NSCLC patients. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 4, 2024 Category: Cancer & Oncology Authors: Shengnan Ren,
Lingxin Feng,
Haoran Liu,
Yuke Mao,
Zhuang Yu Tags: ORIGINAL ARTICLE Source Type: research
Surgery challenges and postoperative complications of lung cancer after neoadjuvant immunotherapy
ConclusionsCompared to immunotherapy alone or in combination with apatinib, neoadjuvant chemoimmunotherapy could increase the difficulty of surgery while the incidence of postoperative complications remained acceptable. The conversion to open surgery and pneumonectomy after neoadjuvant immunotherapy should be reduced. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 4, 2024 Category: Cancer & Oncology Authors: Guangyu Bai,
Xiaowei Chen,
Yue Peng,
Ying Ji,
Fenglong Bie,
Yang Liu,
Zhenlin Yang,
Shugeng Gao Tags: ORIGINAL ARTICLE Source Type: research
Considerations for multidisciplinary management of synchronous primary breast cancer and primary lung cancer – Analysis of thirty‐one patients
ConclusionRoutine chest CT is needed for breast cancer patients before surgery, and PET-CT is required for the accurate staging of lung cancer patients. A multidisciplinary expert team should manage synchronous primary breast cancer and primary lung cancer. Emphasis should be placed on patients who need preoperative treatment before surgery. Particularly, for patients who need preoperative chemotherapy, a regimen should be chosen that balances the treatment of lung cancer and breast cancer. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 4, 2024 Category: Cancer & Oncology Authors: Xue Chen,
Yi ‐fan Fang,
Wan‐Pu Yan Tags: ORIGINAL ARTICLE Source Type: research
Navigating venous thromboembolism risks in lung cancer patients
(Source: Thoracic Cancer)
Source: Thoracic Cancer - April 4, 2024 Category: Cancer & Oncology Authors: Si ‐Wai Vivian Chiu,
Chao‐Ming Hung,
Jiun‐Rung Chen,
Li‐Ren Yeh,
Chong‐Chi Chiu Tags: LETTER TO THE EDITOR Source Type: research
Personalized, tumor ‐informed, circulating tumor DNA assay for detecting minimal residual disease in non‐small cell lung cancer patients receiving curative treatments
ConclusionOur real-world data indicate that longitudinal, personalized, tumor-informed ctDNA monitoring is a valuable tool in patients with NSCLC receiving curative treatment to identify patients at high risk for recurrence. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 2, 2024 Category: Cancer & Oncology Authors: Youjin Oh,
Sung Mi Yoon,
Jeeyeon Lee,
Joo Hee Park,
Soowon Lee,
Timothy Hong,
Liam Il ‐young Chung,
Sumedha Sudhaman,
Timothy Riddell,
Charuta C. Palsuledesai,
Michael Krainock,
Minetta C. Liu,
Young Kwang Chae Tags: ORIGINAL ARTICLE Source Type: research
Identification of a risk score model based on tertiary lymphoid structure ‐related genes for predicting immunotherapy efficacy in non‐small cell lung cancer
ConclusionsOur data suggested a pivotal role of TLSs formation in survival outcome and immunotherapy response of NSCLC patients. Tumors with mature TLS formation showed more activated immune microenvironment. In addition, the model constructed by TLS-related genes could predict the response to immunotherapy and is meaningful for clinical decision-making. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Shi ‐Qi Mei,
Jia‐Qi Liu,
Zi‐Jian Huang,
Wei‐Chi Luo,
Ying‐Long Peng,
Zhi‐Hong Chen,
Yu Deng,
Chong‐Rui Xu,
Qing Zhou Tags: ORIGINAL ARTICLE Source Type: research
Circ ‐POSTN promotes the progression and reduces radiosensitivity in esophageal cancer by regulating the miR‐876‐5p/FYN axis
ConclusionCirc-POSTN knockdown inhibited proliferation and invasion, but increased apoptosis and enhanced radiosensitivity in EC cells via modulating miR-876-5p/FYN axis, which might be a potential diagnostic and therapeutic target for EC. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 30, 2024 Category: Cancer & Oncology Authors: Alan Chu,
Chen Sun,
Zongwen Liu,
Shijia Liu,
Mengxi Li,
Rui Song,
Lanlan Gan,
Yongtai Wang,
Ruitai Fan Tags: ORIGINAL ARTICLE Source Type: research
Clinical significance of postoperative folate receptor ‐positive circulating tumor cells (FR + CTCs) for long‐term prognosis in patients with invasive adenocarcinoma (IAC) of the lung
ConclusionThe detection of FR + CTCs postoperatively was an independent predictor of recurrence in patients treated for stage I–III IAC. Standardized detection methods and optimal time points for assessment should be established in future studies. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 27, 2024 Category: Cancer & Oncology Authors: Zeming Ma,
Zhiwei Zhou,
Shijie Wang,
Hong Ji,
Dachuan Zhao,
Liang Wang,
Jinfeng Chen Tags: ORIGINAL ARTICLE Source Type: research
Neoadjuvant chemoimmunotherapy for locally advanced esophageal squamous cell carcinoma: Data from literature review and a real ‐world analysis
ConclusionNCIT is safe and provides potential survival benefits for patients with locally advanced ESCC. However, randomized phase 3 trial data is still needed. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 27, 2024 Category: Cancer & Oncology Authors: Yao Zhang,
Huiting Li,
Bo Yu,
Si Sun,
Zhihuang Hu,
Xianghua Wu,
Yang Zhang,
Bin Li,
Yawei Zhang,
Jiaqing Xiang,
Jialei Wang,
Hui Yu Tags: ORIGINAL ARTICLE Source Type: research
Tracheomediastinal fistula induced by concurrent chemoradiotherapy in small cell lung cancer: A case report and literature review
In this report, we also review previous studies of tracheomediastinal and bronchomediastinal fistulas and summarize the clinical features. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Yoshihiro Yamamoto,
Daisuke Shibahara,
Taro Mori,
Kohei Otsubo,
Yoshimasa Shiraishi,
Yasuto Yoneshima,
Eiji Iwama,
Kentaro Tanaka,
Yoshinao Oda,
Isamu Okamoto Tags: CASE REPORT Source Type: research
A component of high ‐grade fetal lung adenocarcinoma diagnosed as the cause of lymph node metastasis
In this report, we describe a case in which 15% of the adenocarcinoma components were H-FLAC diagnosed as the cause of lymph node metastasis. A 75-year-old man presented with suspected primary lung cancer (clinical stage IIA, T2bN0M0) and underwent left upper lobectomy and superior mediastinal lymph node dissection. Postoperative histopathology revealed lung cancer with only lobar bronchial lymph node (#11) metastasis. Approximately 60% of the invasive adenocarcinoma showed a papillary morphology, 25% showed a lepidic morphology, and 15% showed a fetal morphology. The histomorphological and immunohistological features of #...
Source: Thoracic Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Daichi Ishii,
Satoshi Aoyama,
Wataru Arai,
Masaru Hasegawa,
Akihiko Tanaka,
Motoki Sakuraba Tags: CASE REPORT Source Type: research
Prediction performance comparison of biomarkers for response to immune checkpoint inhibitors in advanced non ‐small cell lung cancer
ConclusionCombined biomarkers have superior predictive accuracy than single biomarkers for immunotherapy response of NSCLC. Further investigation is warranted to select optimal biomarkers for various clinical settings. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Jie Zhao,
Wei Zhuang,
Boyang Sun,
Hua Bai,
Zhijie Wang,
Jia Zhong,
Rui Wan,
Lihui Liu,
Jianchun Duan,
Jie Wang Tags: ORIGINAL ARTICLE Source Type: research
Anaplastic large cell lymphoma with ALK::ATIC fusion mimicking a histiocytic sarcoma debuting as an anterior thoracic soft tissue tumor with exceptional clinicopathological, morphological and molecular features
AbstractA 56-year-old woman debuted with a palpable painless mass in the anterior thorax wall at the level of the second and third right parasternal intercostal space, which progressively increased in size over 5 months accompanied by localized skin rash, mild dyspnea and chest pain when changing position. Imaging studies showed a soft tissue mass measuring 75 × 62 mm and a density of 34 Hounsfield Units that had caused the lysis of the costal arches and grew expansively towards the anterior medias tinum, without identifying mediastinal adenopathies only by this imaging method. Core biopsy was performed, which wa...
Source: Thoracic Cancer - March 25, 2024 Category: Cancer & Oncology Authors: Jos é Antonio García‐Muñiz,
Natalia Vilches‐Cisneros,
Juan Pablo Flores‐Gutiérrez,
Oralia Barboza‐Quintana Tags: CASE REPORT Source Type: research
Screening for depression and anxiety in lung cancer patients: A real ‐world study using GAD‐7 and HADS
ConclusionThe study affirms the feasibility of GAD-7, PHQ-9, and HADS as screening tools for depressive and anxiety symptoms in lung cancer patients. It further highlights tobacco and alcohol consumption as significant risk factors for poor psychological health in this population. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 25, 2024 Category: Cancer & Oncology Authors: Yi Fung Chau,
Huixia Zhou,
Bolu Chen,
Hengqin Ren,
Zixiao Ma,
Xiangyang Zhang,
Jianchun Duan Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Thoracic Cancer)
Source: Thoracic Cancer - March 25, 2024 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research
