This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
Defining the functional influence of endothelial cell-expressed oncogenic activating mutations on vascular morphogenesis and capillary assembly
Am J Pathol. 2023 Oct 12:S0002-9440(23)00375-9. doi: 10.1016/j.ajpath.2023.08.017. Online ahead of print.ABSTRACTWe sought to define key molecules and signals controlling major steps in vascular morphogenesis, and how these signals regulate pericyte recruitment and pericyte-induced basement membrane deposition. The morphogenic impact of EC expression of activating mutants of kRas, Mek1, PIK3CA, Akt1, Rheb, Jak2, or Stat3 expression vs. controls was evaluated, along with EC signaling events, pharmacological inhibitor assays, and siRNA suppression experiments. We observe that primary stimulators of EC lumen formation include...
Source: The American Journal of Pathology - October 14, 2023 Category: Pathology Authors: Prisca K Lin Zheying Sun George E Davis Source Type: research
DOCK2 promotes atherosclerosis by mediating the endothelial cell inflammatory response
This study aims to explore the role of dedicator of cytokinesis 2 (DOCK2) in the pathogenesis of atherosclerosis. Low-density lipoprotein receptor (LDLR)-deficient mice with DOCK2 deficiency (LDLR-/-DOCK2-/-) and control (LDLR-/-) mice were fed with a high-fat diet (HFD) to induce atherosclerosis. The aortas and aortic roots were collected for atherosclerosis analysis. DOCK2 expression was induced in atherosclerotic lesions with increased expression of ICAM-1 and VCAM-1 after HFD for 4 weeks in LDLR-/- mice. LDLR-/-DOCK2-/- mice exhibited significantly decreased Oil-Red O (ORO) staining in both aortic roots and aortas comp...
Source: The American Journal of Pathology - October 14, 2023 Category: Pathology Authors: Guoqing Qian Oluwaseun Adeyanju Dunpeng Cai Torry A Tucker Steven Idell Shi-You Chen Xia Guo Source Type: research
Introducing the Ocular Pathobiology Topic Category in The American Journal of Pathology
Am J Pathol. 2023 Nov;193(11):1620-1621. doi: 10.1016/j.ajpath.2023.09.002.NO ABSTRACTPMID:37838454 | DOI:10.1016/j.ajpath.2023.09.002 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 14, 2023 Category: Pathology Authors: Patricia A D'Amore Source Type: research
Defining the functional influence of endothelial cell-expressed oncogenic activating mutations on vascular morphogenesis and capillary assembly
Am J Pathol. 2023 Oct 12:S0002-9440(23)00375-9. doi: 10.1016/j.ajpath.2023.08.017. Online ahead of print.ABSTRACTWe sought to define key molecules and signals controlling major steps in vascular morphogenesis, and how these signals regulate pericyte recruitment and pericyte-induced basement membrane deposition. The morphogenic impact of EC expression of activating mutants of kRas, Mek1, PIK3CA, Akt1, Rheb, Jak2, or Stat3 expression vs. controls was evaluated, along with EC signaling events, pharmacological inhibitor assays, and siRNA suppression experiments. We observe that primary stimulators of EC lumen formation include...
Source: The American Journal of Pathology - October 14, 2023 Category: Pathology Authors: Prisca K Lin Zheying Sun George E Davis Source Type: research
DOCK2 promotes atherosclerosis by mediating the endothelial cell inflammatory response
This study aims to explore the role of dedicator of cytokinesis 2 (DOCK2) in the pathogenesis of atherosclerosis. Low-density lipoprotein receptor (LDLR)-deficient mice with DOCK2 deficiency (LDLR-/-DOCK2-/-) and control (LDLR-/-) mice were fed with a high-fat diet (HFD) to induce atherosclerosis. The aortas and aortic roots were collected for atherosclerosis analysis. DOCK2 expression was induced in atherosclerotic lesions with increased expression of ICAM-1 and VCAM-1 after HFD for 4 weeks in LDLR-/- mice. LDLR-/-DOCK2-/- mice exhibited significantly decreased Oil-Red O (ORO) staining in both aortic roots and aortas comp...
Source: The American Journal of Pathology - October 14, 2023 Category: Pathology Authors: Guoqing Qian Oluwaseun Adeyanju Dunpeng Cai Torry A Tucker Steven Idell Shi-You Chen Xia Guo Source Type: research
Introducing the Ocular Pathobiology Topic Category in The American Journal of Pathology
Am J Pathol. 2023 Nov;193(11):1620-1621. doi: 10.1016/j.ajpath.2023.09.002.NO ABSTRACTPMID:37838454 | DOI:10.1016/j.ajpath.2023.09.002 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 14, 2023 Category: Pathology Authors: Patricia A D'Amore Source Type: research
Defining the functional influence of endothelial cell-expressed oncogenic activating mutations on vascular morphogenesis and capillary assembly
Am J Pathol. 2023 Oct 12:S0002-9440(23)00375-9. doi: 10.1016/j.ajpath.2023.08.017. Online ahead of print.ABSTRACTWe sought to define key molecules and signals controlling major steps in vascular morphogenesis, and how these signals regulate pericyte recruitment and pericyte-induced basement membrane deposition. The morphogenic impact of EC expression of activating mutants of kRas, Mek1, PIK3CA, Akt1, Rheb, Jak2, or Stat3 expression vs. controls was evaluated, along with EC signaling events, pharmacological inhibitor assays, and siRNA suppression experiments. We observe that primary stimulators of EC lumen formation include...
Source: The American Journal of Pathology - October 14, 2023 Category: Pathology Authors: Prisca K Lin Zheying Sun George E Davis Source Type: research
