Vitamin D Receptor Activation Reduces Hepatic Inflammation via Enhancing Macrophage Autophagy in Cholestatic Mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, whether the vitamin D/vitamin D receptor (VDR) axis could up-regulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis was investigated. Paricalcitol (PAL; VDR agonist) was intraperitoneally injected into bile duct-ligated mice for 5 days. Research found that up-regulation of VDR expression by PAL reduced l...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Androgen Receptor-Interacting Proteins in Prostate Cancer Development and Therapy Resistance
Am J Pathol. 2023 Dec 15:S0002-9440(23)00461-3. doi: 10.1016/j.ajpath.2023.12.003. Online ahead of print.ABSTRACTEndocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (>280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the antiandrogen enzalutamide. The...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Zoran Culig Martin Puhr Source Type: research
Vitamin D Receptor Activation Reduces Hepatic Inflammation via Enhancing Macrophage Autophagy in Cholestatic Mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, whether the vitamin D/vitamin D receptor (VDR) axis could up-regulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis was investigated. Paricalcitol (PAL; VDR agonist) was intraperitoneally injected into bile duct-ligated mice for 5 days. Research found that up-regulation of VDR expression by PAL reduced l...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Androgen Receptor-Interacting Proteins in Prostate Cancer Development and Therapy Resistance
Am J Pathol. 2023 Dec 15:S0002-9440(23)00461-3. doi: 10.1016/j.ajpath.2023.12.003. Online ahead of print.ABSTRACTEndocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (>280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the antiandrogen enzalutamide. The...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Zoran Culig Martin Puhr Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Androgen receptor interacting proteins in prostate cancer development and therapy resistance
Am J Pathol. 2023 Dec 15:S0002-9440(23)00461-3. doi: 10.1016/j.ajpath.2023.12.003. Online ahead of print.ABSTRACTEndocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (> 280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the anti-androgen enzalutamide. T...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Zoran Culig Martin Puhr Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Androgen receptor interacting proteins in prostate cancer development and therapy resistance
Am J Pathol. 2023 Dec 15:S0002-9440(23)00461-3. doi: 10.1016/j.ajpath.2023.12.003. Online ahead of print.ABSTRACTEndocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (> 280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the anti-androgen enzalutamide. T...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Zoran Culig Martin Puhr Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Androgen receptor interacting proteins in prostate cancer development and therapy resistance
Am J Pathol. 2023 Dec 15:S0002-9440(23)00461-3. doi: 10.1016/j.ajpath.2023.12.003. Online ahead of print.ABSTRACTEndocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (> 280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the anti-androgen enzalutamide. T...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Zoran Culig Martin Puhr Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Androgen receptor interacting proteins in prostate cancer development and therapy resistance
Am J Pathol. 2023 Dec 15:S0002-9440(23)00461-3. doi: 10.1016/j.ajpath.2023.12.003. Online ahead of print.ABSTRACTEndocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (> 280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the anti-androgen enzalutamide. T...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Zoran Culig Martin Puhr Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Androgen receptor interacting proteins in prostate cancer development and therapy resistance
Am J Pathol. 2023 Dec 15:S0002-9440(23)00461-3. doi: 10.1016/j.ajpath.2023.12.003. Online ahead of print.ABSTRACTEndocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (> 280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the anti-androgen enzalutamide. T...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Zoran Culig Martin Puhr Source Type: research
Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, to determine whether the vitamin D (VD)/ VD receptor (VDR) axis could upregulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis. Paricalcitol (PAL, VDR agonist) was intraperitoneally injected into bile duct ligated (BDL) mice for 5 days. Research found that upregulation of VDR expression by PAL reduced li...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
