Sleep Deprivation Impairs Intestinal Mucosal Barrier by Activating Endoplasmic Reticulum Stress in Goblet Cells
Am J Pathol. 2023 Oct 31:S0002-9440(23)00412-1. doi: 10.1016/j.ajpath.2023.10.004. Online ahead of print.ABSTRACTSleep deficiency is frequently associated with intestinal inflammatory conditions and has been increasingly recognized as a public health concern worldwide. However, the effects of sleep deficiency on intestinal goblet cells (GCs), which play a major role in intestinal barrier formation, remain elusive. Herein, we determined the effects of sleep deprivation on intestinal GCs using a sleep-deprivation mouse model. Sleep deprivation impaired the intestinal mucosal barrier and decreased the expression of tight junc...
Source: The American Journal of Pathology - November 2, 2023 Category: Pathology Authors: Gaoxiang Li Mengru Gao Shuangshuang Zhang Tianliang Dai Fei Wang Jinke Geng Jia Rao Xuejia Qin Jizhao Qian Li Zuo Meng Zhou Lixin Liu Hong Zhou Source Type: research
KLK4 promotes proliferation, migration, invasion, and pro-angiogenesis of endometrial stromal cells via regulation of regulation of BDNF production in endometriosis
Am J Pathol. 2023 Oct 31:S0002-9440(23)00413-3. doi: 10.1016/j.ajpath.2023.10.006. Online ahead of print.ABSTRACTEndometriosis is a common benign gynecologic condition. Endometriosis lesions are associated with endometrial cell proliferation, migration, invasion, and neovascularization, while the specific molecular mechanisms are still elusive. Transcriptome sequencing has been used for the identification of diagnostic markers in endometriosis. Here, transcriptome profiling revealed that kallikrein related peptidase 4 (KLK4) expression was up-regulated in ectopic endometrium (EC) tissues of patients with endometriosis. KLK...
Source: The American Journal of Pathology - November 2, 2023 Category: Pathology Authors: Jingwen Shi Yue Qi Yuanchen Sun Ying Huang Source Type: research
Interleukin-6 reduces spheroid sizes of osteophytic cells derived from osteoarthritis knee joint via induction of apoptosis
Am J Pathol. 2023 Oct 31:S0002-9440(23)00411-X. doi: 10.1016/j.ajpath.2023.10.005. Online ahead of print.ABSTRACTOsteophyte in osteoarthritis (OA) joints contributes to restriction of joint movement, joint pain, and OA progression, but little is known about regulators of osteophyte. By examining the expression of the genes related to cartilage extracellular matrix (ECM), endochondral ossification and growth factor-signaling in articular cartilage and osteophyte obtained from OA knee joints, we demonstrated that several genes such as COL1A1, VCAN, BGLAP, BMP8B, RUNX2, and SOST are overexpressed in osteophyte compared to art...
Source: The American Journal of Pathology - November 2, 2023 Category: Pathology Authors: Yoshifumi Negishi Arepati Adili Susana de Vega Masahiro Momoeda Haruka Kaneko Mehmet Zeynel Cilek Chiho Yoshinaga Kazuaki Takafuji Yuta Otsuka Masayuki Shimoda Takako Negishi-Koga Muneaki Ishijima Yasunori Okada Source Type: research
Phenotypic and Functional Diversity of Neutrophils in Gut Inflammation and Cancer
Am J Pathol. 2023 Oct 31:S0002-9440(23)00416-9. doi: 10.1016/j.ajpath.2023.10.009. Online ahead of print.ABSTRACTNeutrophils (PMNs) execute important effector functions protecting the host against invading pathogens, however their activity in tissue can exacerbate inflammation and inflammation-associated tissue injury and tumorigenesis. Until recently PMN were considered to be short-lived, terminally differentiated phagocytes, however this view is rapidly changing with the emerging evidence of increased PMN lifespan in tissues, PMN plasticity and phenotypic heterogeneity. Specialized PMN subsets have been identified in inf...
Source: The American Journal of Pathology - November 2, 2023 Category: Pathology Authors: Ronen Sumagin Source Type: research
Sleep Deprivation Impairs Intestinal Mucosal Barrier by Activating Endoplasmic Reticulum Stress in Goblet Cells
Am J Pathol. 2023 Oct 31:S0002-9440(23)00412-1. doi: 10.1016/j.ajpath.2023.10.004. Online ahead of print.ABSTRACTSleep deficiency is frequently associated with intestinal inflammatory conditions and has been increasingly recognized as a public health concern worldwide. However, the effects of sleep deficiency on intestinal goblet cells (GCs), which play a major role in intestinal barrier formation, remain elusive. Herein, we determined the effects of sleep deprivation on intestinal GCs using a sleep-deprivation mouse model. Sleep deprivation impaired the intestinal mucosal barrier and decreased the expression of tight junc...
Source: The American Journal of Pathology - November 2, 2023 Category: Pathology Authors: Gaoxiang Li Mengru Gao Shuangshuang Zhang Tianliang Dai Fei Wang Jinke Geng Jia Rao Xuejia Qin Jizhao Qian Li Zuo Meng Zhou Lixin Liu Hong Zhou Source Type: research
KLK4 promotes proliferation, migration, invasion, and pro-angiogenesis of endometrial stromal cells via regulation of regulation of BDNF production in endometriosis
Am J Pathol. 2023 Oct 31:S0002-9440(23)00413-3. doi: 10.1016/j.ajpath.2023.10.006. Online ahead of print.ABSTRACTEndometriosis is a common benign gynecologic condition. Endometriosis lesions are associated with endometrial cell proliferation, migration, invasion, and neovascularization, while the specific molecular mechanisms are still elusive. Transcriptome sequencing has been used for the identification of diagnostic markers in endometriosis. Here, transcriptome profiling revealed that kallikrein related peptidase 4 (KLK4) expression was up-regulated in ectopic endometrium (EC) tissues of patients with endometriosis. KLK...
Source: The American Journal of Pathology - November 2, 2023 Category: Pathology Authors: Jingwen Shi Yue Qi Yuanchen Sun Ying Huang Source Type: research
Interleukin-6 reduces spheroid sizes of osteophytic cells derived from osteoarthritis knee joint via induction of apoptosis
Am J Pathol. 2023 Oct 31:S0002-9440(23)00411-X. doi: 10.1016/j.ajpath.2023.10.005. Online ahead of print.ABSTRACTOsteophyte in osteoarthritis (OA) joints contributes to restriction of joint movement, joint pain, and OA progression, but little is known about regulators of osteophyte. By examining the expression of the genes related to cartilage extracellular matrix (ECM), endochondral ossification and growth factor-signaling in articular cartilage and osteophyte obtained from OA knee joints, we demonstrated that several genes such as COL1A1, VCAN, BGLAP, BMP8B, RUNX2, and SOST are overexpressed in osteophyte compared to art...
Source: The American Journal of Pathology - November 2, 2023 Category: Pathology Authors: Yoshifumi Negishi Arepati Adili Susana de Vega Masahiro Momoeda Haruka Kaneko Mehmet Zeynel Cilek Chiho Yoshinaga Kazuaki Takafuji Yuta Otsuka Masayuki Shimoda Takako Negishi-Koga Muneaki Ishijima Yasunori Okada Source Type: research
Phenotypic and Functional Diversity of Neutrophils in Gut Inflammation and Cancer
Am J Pathol. 2023 Oct 31:S0002-9440(23)00416-9. doi: 10.1016/j.ajpath.2023.10.009. Online ahead of print.ABSTRACTNeutrophils (PMNs) execute important effector functions protecting the host against invading pathogens, however their activity in tissue can exacerbate inflammation and inflammation-associated tissue injury and tumorigenesis. Until recently PMN were considered to be short-lived, terminally differentiated phagocytes, however this view is rapidly changing with the emerging evidence of increased PMN lifespan in tissues, PMN plasticity and phenotypic heterogeneity. Specialized PMN subsets have been identified in inf...
Source: The American Journal of Pathology - November 2, 2023 Category: Pathology Authors: Ronen Sumagin Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Oct 15:S0002-9440(23)00380-2. doi: 10.1016/j.ajpath.2023.10.003. Online ahead of print.NO ABSTRACTPMID:37848134 | DOI:10.1016/j.ajpath.2023.10.003 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - October 17, 2023 Category: Pathology Source Type: research
