Overexpression of Corin Ameliorates Kidney fibrosis through Inhibition of Wnt/ β-Catenin Signaling in Mice
Am J Pathol. 2023 Oct 10:S0002-9440(23)00364-4. doi: 10.1016/j.ajpath.2023.09.008. Online ahead of print.ABSTRACTThe Wnt/β-catenin pathway represents a promising therapeutic target for mitigating kidney fibrosis. Corin possesses the homologous ligand binding site (Frizzled-cysteine rich domain, Fz-CRD) similar to Frizzled proteins, which act as receptors for Wnt. The Fz-CRD has been found in eight different proteins, all of which, except for corin, are known to bind Wnt and regulate its signal transmission. It is hypothesized that corin may inhibit the Wnt/β-catenin signaling pathway and thereby reduce fibrogenesis. Redu...
Source: The American Journal of Pathology - October 12, 2023 Category: Pathology Authors: Xiaole Su Sijia Li Yanru Zhang Xuan Tie Rongrong Feng Xiaojiao Guo Xi Qiao Lihua Wang Source Type: research
Cell Plasticity in a Mouse Model of Benign Prostate Hyperplasia Drives Amplification of Androgen-Independent Epithelial Cell Populations Sensitive to Antioxidant Therapy
Am J Pathol. 2023 Oct 10:S0002-9440(23)00366-8. doi: 10.1016/j.ajpath.2023.09.010. Online ahead of print.ABSTRACTBenign prostate hyperplasia (BPH) is caused by the non-malignant enlargement of the transition zone of the prostate gland, leading to lower urinary tract symptoms (LUTS). While current medical treatments are unsatisfactory in many patients, the limited understanding of the mechanisms driving disease progression prevents the development of alternative therapeutic strategies. The probasin-prolactin (Pb-PRL) transgenic mouse recapitulates many histopathological features of human BPH. We here show that these alterat...
Source: The American Journal of Pathology - October 12, 2023 Category: Pathology Authors: Le ïla Dos Santos Francesco Carbone Emeline Pacreau Sekou Diarra Marine Luka Natascha Pigat Manon Baures Emilie Navarro Julien Anract Nicolas Barry Delongchamps Nicolas Cagnard Fr édéric Bost Ivan Nemazanyy Olivier Petitjean Ahmed Hama ï Micka ël Men Source Type: research
The Neuropeptide alpha-Melanocyte Stimulating Hormone ( α-MSH) Prevents Persistent Corneal Edema Following Injury
In this study, we investigate the efficacy of the neuropeptide alpha-melanocyte stimulating hormone (α-MSH) in promoting endothelial regeneration during the critical window between ocular injury and the onset of endothelial decompensation using an established murine model of injury using transcorneal freezing. Local administration of α-MSH following injury prevented corneal edema and opacity, reduced leukocyte infiltration, and limited CEnC apoptosis while promoting their proliferation. Our results suggest that α-MSH has pro-regenerative and cytoprotective function on CEnC and shows a promise as a therapy for prevention...
Source: The American Journal of Pathology - October 12, 2023 Category: Pathology Authors: Hamid Alemi Shudan Wang Tomas Blanco Francesca Kahale Rohan Bir Singh Gustavo Ortiz Aytan Musayeva Erdem Yuksel Kunpeng Pang Neha Deshpande Thomas H Dohlman Ula V Jurkunas Jia Yin Reza Dana Source Type: research
The Role of Endothelial Cells in Atherosclerosis: Insights from Genetic Association Studies
Am J Pathol. 2023 Oct 10:S0002-9440(23)00373-5. doi: 10.1016/j.ajpath.2023.09.012. Online ahead of print.ABSTRACTEndothelial cells (ECs) mediate several biological functions that are relevant to atherosclerosis and coronary artery disease (CAD), regulating an array of vital processes including vascular tone, wound healing, reactive oxygen species, shear stress response, and inflammation. Although it is not yet known which of these functions is causally linked with CAD development and/or progression, genome-wide association studies (GWASs) have implicated over 400 loci associated with CAD risk, among which several have demo...
Source: The American Journal of Pathology - October 12, 2023 Category: Pathology Authors: Mark E Pepin Rajat Gupta Source Type: research
Overexpression of Corin Ameliorates Kidney fibrosis through Inhibition of Wnt/ β-Catenin Signaling in Mice
Am J Pathol. 2023 Oct 10:S0002-9440(23)00364-4. doi: 10.1016/j.ajpath.2023.09.008. Online ahead of print.ABSTRACTThe Wnt/β-catenin pathway represents a promising therapeutic target for mitigating kidney fibrosis. Corin possesses the homologous ligand binding site (Frizzled-cysteine rich domain, Fz-CRD) similar to Frizzled proteins, which act as receptors for Wnt. The Fz-CRD has been found in eight different proteins, all of which, except for corin, are known to bind Wnt and regulate its signal transmission. It is hypothesized that corin may inhibit the Wnt/β-catenin signaling pathway and thereby reduce fibrogenesis. Redu...
Source: The American Journal of Pathology - October 12, 2023 Category: Pathology Authors: Xiaole Su Sijia Li Yanru Zhang Xuan Tie Rongrong Feng Xiaojiao Guo Xi Qiao Lihua Wang Source Type: research
