Ficolin-A/2 aggravated severe lung injury through NETs mediated by GSDMD-induced pyroptosis
In conclusion, these results suggested that Ficolin-A/2 exacerbated NET formation and LPS-induced lung injury via the GSDMD-mediated pyroptosis.PMID:38442803 | DOI:10.1016/j.ajpath.2024.02.011 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - March 5, 2024 Category: Pathology Authors: Li Huang Xiaowu Tan Weixia Xuan Qing Luo Li Xie Yunzhu Xi Rong Li Li Li Feifan Li Meiyun Zhao Yongliang Jiang Xu Wu Source Type: research

Deletion of MyD88 in T-cells Improves Anti-Tumor Activity in Melanoma
Am J Pathol. 2024 Mar 3:S0002-9440(24)00083-X. doi: 10.1016/j.ajpath.2024.02.012. Online ahead of print.ABSTRACTCytotoxic CD8+ T-cells are central to the anti-tumor immune response by releasing cytotoxic granules that kill tumor cells. They are activated by antigen presenting cells, which become activated by DAMPs (damage associated molecular patterns) through MyD88 (myeloid differentiation response 88). However, the suppressive tumor microenvironment promotes T-cell tolerance to tumor antigens in part by enhancing the activity of immune checkpoint molecules that prevent CD8+ T-cell activation and cytotoxicity. We recently...
Source: The American Journal of Pathology - March 5, 2024 Category: Pathology Authors: Abraham L Bayer Darwing Padilla-Rolon Sasha Smolgovsky Philip Hinds Pilar Alcaide Source Type: research

Ficolin-A/2 aggravated severe lung injury through NETs mediated by GSDMD-induced pyroptosis
In conclusion, these results suggested that Ficolin-A/2 exacerbated NET formation and LPS-induced lung injury via the GSDMD-mediated pyroptosis.PMID:38442803 | DOI:10.1016/j.ajpath.2024.02.011 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - March 5, 2024 Category: Pathology Authors: Li Huang Xiaowu Tan Weixia Xuan Qing Luo Li Xie Yunzhu Xi Rong Li Li Li Feifan Li Meiyun Zhao Yongliang Jiang Xu Wu Source Type: research

Deletion of MyD88 in T-cells Improves Anti-Tumor Activity in Melanoma
Am J Pathol. 2024 Mar 3:S0002-9440(24)00083-X. doi: 10.1016/j.ajpath.2024.02.012. Online ahead of print.ABSTRACTCytotoxic CD8+ T-cells are central to the anti-tumor immune response by releasing cytotoxic granules that kill tumor cells. They are activated by antigen presenting cells, which become activated by DAMPs (damage associated molecular patterns) through MyD88 (myeloid differentiation response 88). However, the suppressive tumor microenvironment promotes T-cell tolerance to tumor antigens in part by enhancing the activity of immune checkpoint molecules that prevent CD8+ T-cell activation and cytotoxicity. We recently...
Source: The American Journal of Pathology - March 5, 2024 Category: Pathology Authors: Abraham L Bayer Darwing Padilla-Rolon Sasha Smolgovsky Philip Hinds Pilar Alcaide Source Type: research

Tumor necrosis factor alpha-induced protein 8-like 1 binds to protein arginine methyltransferase 1 to suppress the methylation of signal transducer and activator of transcription 3 and cell growth in oral squamous cell carcinoma
Am J Pathol. 2024 Mar 1:S0002-9440(24)00080-4. doi: 10.1016/j.ajpath.2024.02.010. Online ahead of print.ABSTRACTTumor necrosis factor alpha-induced protein 8 (TIPE/TNFAIP8/OXi-α) family are a newly discovered series of proteins involved in immune regulation and tumorigenesis. TIPE1, as the member of TIPE/TNFAIP8/OXi-α family, has emerged as an anti-cancer drug target as it is promotes cancer cell apoptosis and inhibits cell proliferation. Here, the current study aimed to systematically reveal that TIPE1 regulates the activity of protein arginine methyltransferase 1 (PRMT1) and the subsequent methylation of signal transdu...
Source: The American Journal of Pathology - March 3, 2024 Category: Pathology Authors: Bing Liu Wen Si Bo Wei Xuan Zhang Peng Chen Source Type: research

Tumor necrosis factor alpha-induced protein 8-like 1 binds to protein arginine methyltransferase 1 to suppress the methylation of signal transducer and activator of transcription 3 and cell growth in oral squamous cell carcinoma
Am J Pathol. 2024 Mar 1:S0002-9440(24)00080-4. doi: 10.1016/j.ajpath.2024.02.010. Online ahead of print.ABSTRACTTumor necrosis factor alpha-induced protein 8 (TIPE/TNFAIP8/OXi-α) family are a newly discovered series of proteins involved in immune regulation and tumorigenesis. TIPE1, as the member of TIPE/TNFAIP8/OXi-α family, has emerged as an anti-cancer drug target as it is promotes cancer cell apoptosis and inhibits cell proliferation. Here, the current study aimed to systematically reveal that TIPE1 regulates the activity of protein arginine methyltransferase 1 (PRMT1) and the subsequent methylation of signal transdu...
Source: The American Journal of Pathology - March 3, 2024 Category: Pathology Authors: Bing Liu Wen Si Bo Wei Xuan Zhang Peng Chen Source Type: research

Decreased proteasomal function exacerbates ER stress-induced chronic inflammation in obese adipose tissue
This study employed a mouse model with decreased proteasomal function that exhibits age-related phenotypes to investigate the impact of adipocyte senescence on WAT inflammation. Transgenic mice expressing proteasomal subunit β5t with weak chymotrypsin-like activity suffer from reduced lifespan and develop age-related phenotypes. Mice fed with a high-fat diet (HFD) and suffering proteasomal dysfunction exhibited increased WAT inflammation, increased infiltration of pro-inflammatory M1-like macrophages, and increased pro-inflammatory adipocytokines like monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, ...
Source: The American Journal of Pathology - February 29, 2024 Category: Pathology Authors: Shimpei Nakagawa Aya Fukui-Miyazaki Takuma Yoshida Yasushi Ishii Eri Murata Koji Taniguchi Akihiro Ishizu Masanori Kasahara Utano Tomaru Source Type: research

REG γ mitigates radiation-induced enteritis by preserving mucin secretion and sustaining microbiome homeostasis
Am J Pathol. 2024 Feb 27:S0002-9440(24)00077-4. doi: 10.1016/j.ajpath.2024.02.008. Online ahead of print.ABSTRACTRadiation-induced enteritis, a significant concern in abdominal radiation therapy, is closely associated with gut microbiota dysbiosis. The critical mucus layer plays a pivotal role in preventing the translocation of commensal and pathogenic microbes. While the significant expression of REGγ in intestinal epithelial cells is well established, its role in modulating mucus layer and gut microbiota remains enigmatic. Current study revealed notable changes in gut microorganisms and metabolites in irradiated mice la...
Source: The American Journal of Pathology - February 29, 2024 Category: Pathology Authors: Xiangzhan Zhu Ya Li Xue Tian Yiming Jing Zimeng Wang Lingling Yue Jianhui Li Ling Wu Xinkui Zhou Zhidan Yu Yaodong Zhang Fangxia Guan Minglei Yang Bianhong Zhang Source Type: research

Decreased proteasomal function exacerbates ER stress-induced chronic inflammation in obese adipose tissue
This study employed a mouse model with decreased proteasomal function that exhibits age-related phenotypes to investigate the impact of adipocyte senescence on WAT inflammation. Transgenic mice expressing proteasomal subunit β5t with weak chymotrypsin-like activity suffer from reduced lifespan and develop age-related phenotypes. Mice fed with a high-fat diet (HFD) and suffering proteasomal dysfunction exhibited increased WAT inflammation, increased infiltration of pro-inflammatory M1-like macrophages, and increased pro-inflammatory adipocytokines like monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, ...
Source: The American Journal of Pathology - February 29, 2024 Category: Pathology Authors: Shimpei Nakagawa Aya Fukui-Miyazaki Takuma Yoshida Yasushi Ishii Eri Murata Koji Taniguchi Akihiro Ishizu Masanori Kasahara Utano Tomaru Source Type: research

REG γ mitigates radiation-induced enteritis by preserving mucin secretion and sustaining microbiome homeostasis
Am J Pathol. 2024 Feb 27:S0002-9440(24)00077-4. doi: 10.1016/j.ajpath.2024.02.008. Online ahead of print.ABSTRACTRadiation-induced enteritis, a significant concern in abdominal radiation therapy, is closely associated with gut microbiota dysbiosis. The critical mucus layer plays a pivotal role in preventing the translocation of commensal and pathogenic microbes. While the significant expression of REGγ in intestinal epithelial cells is well established, its role in modulating mucus layer and gut microbiota remains enigmatic. Current study revealed notable changes in gut microorganisms and metabolites in irradiated mice la...
Source: The American Journal of Pathology - February 29, 2024 Category: Pathology Authors: Xiangzhan Zhu Ya Li Xue Tian Yiming Jing Zimeng Wang Lingling Yue Jianhui Li Ling Wu Xinkui Zhou Zhidan Yu Yaodong Zhang Fangxia Guan Minglei Yang Bianhong Zhang Source Type: research

Decreased proteasomal function exacerbates ER stress-induced chronic inflammation in obese adipose tissue
This study employed a mouse model with decreased proteasomal function that exhibits age-related phenotypes to investigate the impact of adipocyte senescence on WAT inflammation. Transgenic mice expressing proteasomal subunit β5t with weak chymotrypsin-like activity suffer from reduced lifespan and develop age-related phenotypes. Mice fed with a high-fat diet (HFD) and suffering proteasomal dysfunction exhibited increased WAT inflammation, increased infiltration of pro-inflammatory M1-like macrophages, and increased pro-inflammatory adipocytokines like monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, ...
Source: The American Journal of Pathology - February 29, 2024 Category: Pathology Authors: Shimpei Nakagawa Aya Fukui-Miyazaki Takuma Yoshida Yasushi Ishii Eri Murata Koji Taniguchi Akihiro Ishizu Masanori Kasahara Utano Tomaru Source Type: research

REG γ mitigates radiation-induced enteritis by preserving mucin secretion and sustaining microbiome homeostasis
Am J Pathol. 2024 Feb 27:S0002-9440(24)00077-4. doi: 10.1016/j.ajpath.2024.02.008. Online ahead of print.ABSTRACTRadiation-induced enteritis, a significant concern in abdominal radiation therapy, is closely associated with gut microbiota dysbiosis. The critical mucus layer plays a pivotal role in preventing the translocation of commensal and pathogenic microbes. While the significant expression of REGγ in intestinal epithelial cells is well established, its role in modulating mucus layer and gut microbiota remains enigmatic. Current study revealed notable changes in gut microorganisms and metabolites in irradiated mice la...
Source: The American Journal of Pathology - February 29, 2024 Category: Pathology Authors: Xiangzhan Zhu Ya Li Xue Tian Yiming Jing Zimeng Wang Lingling Yue Jianhui Li Ling Wu Xinkui Zhou Zhidan Yu Yaodong Zhang Fangxia Guan Minglei Yang Bianhong Zhang Source Type: research

Impaired hepatic VLDL secretion promotes tumorigenesis and is accelerated with Fabp1 deletion
Am J Pathol. 2024 Feb 26:S0002-9440(24)00074-9. doi: 10.1016/j.ajpath.2024.02.005. Online ahead of print.ABSTRACTGenetic polymorphisms that impair VLDL secretion are linked to hepatic steatosis, fibrosis and hepatocellular cancer (HCC). Liver-specific deletion of microsomal triglyceride transfer protein (Mttp-LKO) impairs VLDL assembly, promoting hepatic steatosis and fibrosis, which are attenuated in Mttp-LKO X Fabp1 null (Fabp1/Mttp DKO) mice. Here we examine the impact of impaired VLDL secretion in Mttp-LKO mice on HCC incidence and progression in comparison to Fabp1/Mttp DKO mice. DEN treated Mttp-LKO mice exhibited st...
Source: The American Journal of Pathology - February 28, 2024 Category: Pathology Authors: Elizabeth P Newberry Elizabeth A Molitor Allen Liu Kamyar Chong Xiuli Liu Cristina Alonso Jose M Mato Nicholas O Davidson Source Type: research

Metallothionein Alleviates Glutathione Depletion-Induced Oxidative Cardiomyopathy through CISD1-Dependent Regulation of Ferroptosis in Murine Hearts
This study was designed to discern the effect of heavy scavenger metallothionein on glutathione (GSH) deprivation-evoked cardiac anomalies and mechanisms involved with an emphasis on ferroptosis. WT and cardiac metallothionein transgenic mice received GSH synthase inhibitor buthionine sulfoximine (BSO, 30 mM in drinking water) for 14 days prior to assessment of myocardial morphology and function. BSO evoked cardiac remodeling and contractile anomalies including cardiac hypertrophy, interstitial fibrosis, enlarged left ventricular chambers, deranged ejection fraction, fraction shortening, cardiomyocyte contractile capacity,...
Source: The American Journal of Pathology - February 28, 2024 Category: Pathology Authors: Feng-Juan Li Shouzhi Fu Hua Ye Yi-Han Hu Jianxin Chen Jamie R Privratsky Wei Yu Feng Dong Russel J Reiter Maolong Dong Jun Guo Jun Ren Source Type: research

Serine Supports Epithelial and Immune Cell Function in Colitis
Am J Pathol. 2024 Feb 26:S0002-9440(24)00071-3. doi: 10.1016/j.ajpath.2024.01.021. Online ahead of print.ABSTRACTInflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract that are largely driven by immune cell activity, while mucosal healing is critical for remission. Serine is a non-essential amino acid that supports epithelial and immune cell metabolism and proliferation, however, whether these roles impact IBD pathogenesis is not well understood. Here, we show that serine synthesis increases selectively in the epithelial cells of colons from patients with IBD and murine models of...
Source: The American Journal of Pathology - February 28, 2024 Category: Pathology Authors: Ji Dong K Bai Suchandrima Saha Michael Wood Bo Chen Jinyu Li Lukas E Dow David C Montrose Source Type: research