Amino Acid Metabolism and Atherosclerotic Cardiovascular Disease
Am J Pathol. 2024 Jan 1:S0002-9440(23)00487-X. doi: 10.1016/j.ajpath.2023.12.006. Online ahead of print.ABSTRACTDespite significant advances in medical treatments and drug development, atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of death worldwide. Dysregulated lipid metabolism is a well-established driver of ASCVD. Unfortunately, even with potent lipid-lowering therapies, ASCVD related deaths have continued to increase over the last decade, highlighting an incomplete understanding of the underlying risk factors and mechanisms of ASCVD. Accumulating evidence over the last decades indicates a corr...
Source: The American Journal of Pathology - January 3, 2024 Category: Pathology Authors: Sumit Kumar Anand Theresea-Anne Governale Xiangyu Zhang Babak Razani Arif Yurdagul Christopher B Pattillo Oren Rom Source Type: research
Amino Acid Metabolism and Atherosclerotic Cardiovascular Disease
Am J Pathol. 2024 Jan 1:S0002-9440(23)00487-X. doi: 10.1016/j.ajpath.2023.12.006. Online ahead of print.ABSTRACTDespite significant advances in medical treatments and drug development, atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of death worldwide. Dysregulated lipid metabolism is a well-established driver of ASCVD. Unfortunately, even with potent lipid-lowering therapies, ASCVD related deaths have continued to increase over the last decade, highlighting an incomplete understanding of the underlying risk factors and mechanisms of ASCVD. Accumulating evidence over the last decades indicates a corr...
Source: The American Journal of Pathology - January 3, 2024 Category: Pathology Authors: Sumit Kumar Anand Theresea-Anne Governale Xiangyu Zhang Babak Razani Arif Yurdagul Christopher B Pattillo Oren Rom Source Type: research
Amino Acid Metabolism and Atherosclerotic Cardiovascular Disease
Am J Pathol. 2024 Jan 1:S0002-9440(23)00487-X. doi: 10.1016/j.ajpath.2023.12.006. Online ahead of print.ABSTRACTDespite significant advances in medical treatments and drug development, atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of death worldwide. Dysregulated lipid metabolism is a well-established driver of ASCVD. Unfortunately, even with potent lipid-lowering therapies, ASCVD related deaths have continued to increase over the last decade, highlighting an incomplete understanding of the underlying risk factors and mechanisms of ASCVD. Accumulating evidence over the last decades indicates a corr...
Source: The American Journal of Pathology - January 3, 2024 Category: Pathology Authors: Sumit Kumar Anand Theresea-Anne Governale Xiangyu Zhang Babak Razani Arif Yurdagul Christopher B Pattillo Oren Rom Source Type: research
Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Animal Models of Corneal Wound Healing
In this study, using mouse models of corneal wound healing, we demonstrate that topical application of a small molecule inhibitor of galectin-3, GB1265: reduces (i) corneal angiogenesis, (ii) corneal fibrosis, (iii) infiltration of immune cells and (iv) expression of proinflammatory cytokine, IL-1β, in injured corneas. Four independent techniques (RNA-seq, NanoString, RT-qPCR, and Western blot analyses) all demonstrated that decrease in corneal opacity in the galectin-3 inhibitor-treated corneas is associated with a decrease in a number of genes and signaling pathways that are known to promote fibrosis. These findings all...
Source: The American Journal of Pathology - December 30, 2023 Category: Pathology Authors: Zhiyi Cao Abdulraouf Ramadan Albert Tai Fredrik Zetterberg Noorjahan Panjwani Source Type: research
Mammalian Target of Rapamycin Complex 1 Activation in Macrophages Contributes to Persistent Lung Inflammation following Respiratory Tract Viral Infection
Am J Pathol. 2023 Dec 28:S0002-9440(23)00485-6. doi: 10.1016/j.ajpath.2023.11.017. Online ahead of print.ABSTRACTRespiratory tract virus infections cause millions of hospitalizations worldwide each year. Severe infections lead to lung damage that coincides with persistent inflammation and a lengthy repair period. Vaccination and antiviral therapy help to mitigate severe infections before or during the acute stage of disease, but there are currently limited specific treatment options available to individuals experiencing the long-term sequelae of respiratory viral infection. C57BL/6 mice were infected with influenza A/PR/8/...
Source: The American Journal of Pathology - December 30, 2023 Category: Pathology Authors: Brydie R Huckestein Kelly Zeng Rosemary Westcott Jonathan K Alder Danielle Antos Jay K Kolls John F Alcorn Source Type: research
Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Animal Models of Corneal Wound Healing
In this study, using mouse models of corneal wound healing, we demonstrate that topical application of a small molecule inhibitor of galectin-3, GB1265: reduces (i) corneal angiogenesis, (ii) corneal fibrosis, (iii) infiltration of immune cells and (iv) expression of proinflammatory cytokine, IL-1β, in injured corneas. Four independent techniques (RNA-seq, NanoString, RT-qPCR, and Western blot analyses) all demonstrated that decrease in corneal opacity in the galectin-3 inhibitor-treated corneas is associated with a decrease in a number of genes and signaling pathways that are known to promote fibrosis. These findings all...
Source: The American Journal of Pathology - December 30, 2023 Category: Pathology Authors: Zhiyi Cao Abdulraouf Ramadan Albert Tai Fredrik Zetterberg Noorjahan Panjwani Source Type: research
mTORC1 activation in macrophages contributes to persistent lung inflammation following respiratory viral infection
Am J Pathol. 2023 Dec 28:S0002-9440(23)00485-6. doi: 10.1016/j.ajpath.2023.11.017. Online ahead of print.ABSTRACTRespiratory virus infections cause millions of hospitalizations worldwide each year. Severe infections lead to lung damage that coincides with persistent inflammation and a lengthy repair period. Vaccination and anti-viral therapy help to mitigate severe infections prior to or during the acute stage of disease, but there are currently limited specific treatment options available to individuals suffering from the long-term sequelae of respiratory viral infection. C57BL/6 mice were infected with influenza A/PR/8/3...
Source: The American Journal of Pathology - December 30, 2023 Category: Pathology Authors: Brydie R Huckestein Kelly Zeng Rosemary Westcott Jonathan K Alder Danielle Antos Jay K Kolls John F Alcorn Source Type: research
Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Animal Models of Corneal Wound Healing
In this study, using mouse models of corneal wound healing, we demonstrate that topical application of a small molecule inhibitor of galectin-3, GB1265: reduces (i) corneal angiogenesis, (ii) corneal fibrosis, (iii) infiltration of immune cells and (iv) expression of proinflammatory cytokine, IL-1β, in injured corneas. Four independent techniques (RNA-seq, NanoString, RT-qPCR, and Western blot analyses) all demonstrated that decrease in corneal opacity in the galectin-3 inhibitor-treated corneas is associated with a decrease in a number of genes and signaling pathways that are known to promote fibrosis. These findings all...
Source: The American Journal of Pathology - December 30, 2023 Category: Pathology Authors: Zhiyi Cao Abdulraouf Ramadan Albert Tai Fredrik Zetterberg Noorjahan Panjwani Source Type: research
mTORC1 activation in macrophages contributes to persistent lung inflammation following respiratory viral infection
Am J Pathol. 2023 Dec 28:S0002-9440(23)00485-6. doi: 10.1016/j.ajpath.2023.11.017. Online ahead of print.ABSTRACTRespiratory virus infections cause millions of hospitalizations worldwide each year. Severe infections lead to lung damage that coincides with persistent inflammation and a lengthy repair period. Vaccination and anti-viral therapy help to mitigate severe infections prior to or during the acute stage of disease, but there are currently limited specific treatment options available to individuals suffering from the long-term sequelae of respiratory viral infection. C57BL/6 mice were infected with influenza A/PR/8/3...
Source: The American Journal of Pathology - December 30, 2023 Category: Pathology Authors: Brydie R Huckestein Kelly Zeng Rosemary Westcott Jonathan K Alder Danielle Antos Jay K Kolls John F Alcorn Source Type: research
Role of Hepatic Stellate and Liver Sinusoidal Endothelial Cells in a Human Primary Cell Three-Dimensional Model of Nonalcoholic Steatohepatitis (NASH)
Am J Pathol. 2023 Dec 27:S0002-9440(23)00484-4. doi: 10.1016/j.ajpath.2023.12.005. Online ahead of print.ABSTRACTNonalcoholic steatohepatitis (NASH) is an inflammatory and fibrotic liver disease that has reached epidemic proportions and has no approved pharmacological therapies. Research and drug development efforts are hampered by inadequate preclinical models. This research describes a three-dimensional bioprinted liver tissue model of NASH built using primary human hepatocytes and non-parenchymal liver cells (hepatic stellate cells, liver sinusoidal endothelial cells, and Kupffer cells) from either healthy or NASH donor...
Source: The American Journal of Pathology - December 29, 2023 Category: Pathology Authors: Philip K Tan Traci Ostertag Sara B Rosenthal Daisy Chilin-Fuentes Haylee Aidnik Sara Linker Keith Murphy Jeffrey N Miner David A Brenner Source Type: research
Androgen Receptor-Interacting Proteins in Prostate Cancer Development and Therapy Resistance
Am J Pathol. 2023 Dec 15:S0002-9440(23)00461-3. doi: 10.1016/j.ajpath.2023.12.003. Online ahead of print.ABSTRACTEndocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (>280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the antiandrogen enzalutamide. The...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Zoran Culig Martin Puhr Source Type: research
Vitamin D Receptor Activation Reduces Hepatic Inflammation via Enhancing Macrophage Autophagy in Cholestatic Mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, whether the vitamin D/vitamin D receptor (VDR) axis could up-regulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis was investigated. Paricalcitol (PAL; VDR agonist) was intraperitoneally injected into bile duct-ligated mice for 5 days. Research found that up-regulation of VDR expression by PAL reduced l...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Androgen Receptor-Interacting Proteins in Prostate Cancer Development and Therapy Resistance
Am J Pathol. 2023 Dec 15:S0002-9440(23)00461-3. doi: 10.1016/j.ajpath.2023.12.003. Online ahead of print.ABSTRACTEndocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (>280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the antiandrogen enzalutamide. The...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Zoran Culig Martin Puhr Source Type: research
Vitamin D Receptor Activation Reduces Hepatic Inflammation via Enhancing Macrophage Autophagy in Cholestatic Mice
Am J Pathol. 2023 Dec 15:S0002-9440(23)00462-5. doi: 10.1016/j.ajpath.2023.11.016. Online ahead of print.ABSTRACTMacrophage autophagy dysfunction aggravates liver injury by activating inflammasomes, which can cleave pro-IL-1β to its active, secreted form. Here, whether the vitamin D/vitamin D receptor (VDR) axis could up-regulate macrophage autophagy function to inhibit the activation of inflammasome-dependent IL-1β during cholestasis was investigated. Paricalcitol (PAL; VDR agonist) was intraperitoneally injected into bile duct-ligated mice for 5 days. Research found that up-regulation of VDR expression by PAL reduced l...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Tianfu Wen Jing Xie Liman Ma Zhiqing Hao Weiwei Zhang Tingyao Wu Lihua Li Source Type: research
Androgen Receptor-Interacting Proteins in Prostate Cancer Development and Therapy Resistance
Am J Pathol. 2023 Dec 15:S0002-9440(23)00461-3. doi: 10.1016/j.ajpath.2023.12.003. Online ahead of print.ABSTRACTEndocrine therapy for prostate cancer is based on the use of drugs that diminish androgen concentration and androgen receptor (AR) signaling inhibitors and is limited by the functional consequences of AR point mutations and increased expression of constitutively active receptors. Many coactivators (>280) interact with different AR regions. Most studies have determined the expression of coactivators and their effects in the presence of increasing concentrations of androgen or the antiandrogen enzalutamide. The...
Source: The American Journal of Pathology - December 17, 2023 Category: Pathology Authors: Zoran Culig Martin Puhr Source Type: research
