This Month in AJP
Am J Pathol. 2024 Mar;194(3):323. doi: 10.1016/j.ajpath.2024.01.001. Epub 2024 Jan 11.NO ABSTRACTPMID:38365345 | DOI:10.1016/j.ajpath.2024.01.001 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 16, 2024 Category: Pathology Source Type: research
Correction
Am J Pathol. 2024 Mar;194(3):471. doi: 10.1016/j.ajpath.2023.12.004. Epub 2024 Jan 2.NO ABSTRACTPMID:38365346 | DOI:10.1016/j.ajpath.2023.12.004 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 16, 2024 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2024 Mar;194(3):323. doi: 10.1016/j.ajpath.2024.01.001. Epub 2024 Jan 11.NO ABSTRACTPMID:38365345 | DOI:10.1016/j.ajpath.2024.01.001 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 16, 2024 Category: Pathology Source Type: research
Correction
Am J Pathol. 2024 Mar;194(3):471. doi: 10.1016/j.ajpath.2023.12.004. Epub 2024 Jan 2.NO ABSTRACTPMID:38365346 | DOI:10.1016/j.ajpath.2023.12.004 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 16, 2024 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2024 Mar;194(3):323. doi: 10.1016/j.ajpath.2024.01.001. Epub 2024 Jan 11.NO ABSTRACTPMID:38365345 | DOI:10.1016/j.ajpath.2024.01.001 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 16, 2024 Category: Pathology Source Type: research
Correction
Am J Pathol. 2024 Mar;194(3):471. doi: 10.1016/j.ajpath.2023.12.004. Epub 2024 Jan 2.NO ABSTRACTPMID:38365346 | DOI:10.1016/j.ajpath.2023.12.004 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 16, 2024 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2024 Mar;194(3):323. doi: 10.1016/j.ajpath.2024.01.001. Epub 2024 Jan 11.NO ABSTRACTPMID:38365345 | DOI:10.1016/j.ajpath.2024.01.001 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 16, 2024 Category: Pathology Source Type: research
Correction
Am J Pathol. 2024 Mar;194(3):471. doi: 10.1016/j.ajpath.2023.12.004. Epub 2024 Jan 2.NO ABSTRACTPMID:38365346 | DOI:10.1016/j.ajpath.2023.12.004 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 16, 2024 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2024 Feb 10:S0002-9440(24)00048-8. doi: 10.1016/j.ajpath.2024.02.001. Online ahead of print.NO ABSTRACTPMID:38342225 | DOI:10.1016/j.ajpath.2024.02.001 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 11, 2024 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2024 Feb 10:S0002-9440(24)00048-8. doi: 10.1016/j.ajpath.2024.02.001. Online ahead of print.NO ABSTRACTPMID:38342225 | DOI:10.1016/j.ajpath.2024.02.001 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 11, 2024 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2024 Feb 10:S0002-9440(24)00048-8. doi: 10.1016/j.ajpath.2024.02.001. Online ahead of print.NO ABSTRACTPMID:38342225 | DOI:10.1016/j.ajpath.2024.02.001 (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 11, 2024 Category: Pathology Source Type: research
Ninjurin 2 Modulates Tumorigenesis, Inflammation, and Metabolism via Pyroptosis
Am J Pathol. 2024 Feb 5:S0002-9440(24)00044-0. doi: 10.1016/j.ajpath.2024.01.013. Online ahead of print.ABSTRACTThe nerve injury induced protein 2 (NINJ2) belongs to a family of homophilic adhesion molecules and was initially found to be involved in nerve regeneration. However, the role of NINJ2 in other cellular process are not well studied. Here, by generating a Ninj2-deficient mouse model, we showed that mice deficient in Ninj2 have a short lifespan and are prone to spontaneous tumors, systemic inflammation and metabolic defects. To better understand the metabolic traits that contributes to these phenotypes, we performe...
Source: The American Journal of Pathology - February 7, 2024 Category: Pathology Authors: Jin Zhang Xiangmudong Kong Hee Jung Yang Weici Zhang Mingyi Chen Xinbin Chen Source Type: research
Computational Pathology for Prediction of Isocitrate Dehydrogenase Gene Mutation from Whole Slide Images in Adult Patients with Diffuse Glioma
Am J Pathol. 2024 Feb 5:S0002-9440(24)00039-7. doi: 10.1016/j.ajpath.2024.01.009. Online ahead of print.ABSTRACTIsocitrate dehydrogenase gene (IDH) mutation is one of the most important molecular markers of glioma. Accurate detection of IDH status is a crucial step for integrated diagnosis of adult-type diffuse gliomas. A clustering-based hybrid of a convolutional neural network and a vision transformer deep learning model was developed to detect IDH mutation status from annotation-free hematoxylin and eosin-stained whole slide pathologic images of 2275 adult patients with diffuse gliomas. For comparison, we also assessed ...
Source: The American Journal of Pathology - February 7, 2024 Category: Pathology Authors: Yuanshen Zhao Weiwei Wang Yuchen Ji Yang Guo Jingxian Duan Xianzhi Liu Dongming Yan Dong Liang Wencai Li Zhenyu Zhang Zhi-Cheng Li Source Type: research
WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis
In this study, we explored the expression, cellular distribution and function of WSB1 in bleomycin (BLM)-induced mouse lung injury and fibrosis. WSB1 expression was highly induced by BLM injury and correlated with the progression of lung fibrosis. Significantly, conditional deletion of Wsb1 in adult mice ameliorated BLM-induced pulmonary fibrosis. Phenotypically, Wsb1-deficient mice exhibited reduced lipofibroblast (LIF) to MYF transition, but enhanced alveolar type 2 (AT2) proliferation and differentiation into AT1 following BLM injury. Proteomic analysis of mouse lung tissues identified Caveolin 2 as a potential downstre...
Source: The American Journal of Pathology - February 7, 2024 Category: Pathology Authors: Lei Chong Lihui Zou Liyan Xiang Xinyue Song Wanqi Miao Xihua Yan Ming Xu Gongxia Ling Elie El Agha Saverio Bellusci Zhenkun Lou Hailin Zhang Jin-San Zhang Source Type: research
TRPV1 channels facilitate axonal degeneration of corneal sensory nerves in dry eye
Am J Pathol. 2024 Feb 5:S0002-9440(24)00047-6. doi: 10.1016/j.ajpath.2024.01.015. Online ahead of print.ABSTRACTCorneal nerve impairment contributes significantly to dry eye disease (DED) symptoms and is thought to be secondary to corneal epithelial damage. Transient receptor potential vanilloid-1 (TRPV1) channels abound in corneal nerve fibers and respond to inflammation-derived ligands, which increase in DED. TRPV1 overactivation promotes axonal degeneration in vitro but whether it participates in DED-associated corneal nerve dysfunction is unknown. To explore this, DED was surgically induced in wild-type and TRPV1-knock...
Source: The American Journal of Pathology - February 7, 2024 Category: Pathology Authors: Manuela Pizzano Alexia Vereertbrugghen Agostina Cernutto Florencia Sabbione Irene A Keitelman Carolina M Shiromizu Douglas Vera Aguilar Federico Fuentes Mirta N Giordano Anal ía S Trevani Jerem ías G Galletti Source Type: research
