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Southern African Journal of HIV Medicine August 2021
No abstract available. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - October 15, 2021 Category: African Health Authors: David C. Spencer Source Type: research

Five years after Treat All implementation: Botswana ’s HIV response and future directions in the era of COVID-19
Conclusion: The Treat All strategy contributed positively to decreases in new HIV infections, mortality and costs. If significant improvements in differentiated service delivery, increases in human resources and HIV prevention can be realised, Botswana could become one of the first countries with a previously high-burdened generalised HIV epidemic to gain epidemic control, despite the demands of the COVID-19 pandemic. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - October 15, 2021 Category: African Health Authors: Keith Jefferis Source Type: research

Earlier antiretroviral initiation is independently associated with better arterial stiffness in children living with perinatally acquired HIV with sustained viral suppression in Mozambique
Conclusion: Earlier ART initiation was independently associated with lower large artery stiffness. This effect was independent of the effect of elevated lipids, visceral fat and insulin resistance. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - October 14, 2021 Category: African Health Authors: Igor S. Dobe Source Type: research

Strength exercise for balance and gait in HIV-associated distal symmetrical polyneuropathy: A randomised controlled trial
Conclusion: The findings suggest that PRE is beneficial for balance impairment and gait disturbance caused by neuropathy in persons living with HIV and receiving antiretroviral drugs. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - October 5, 2021 Category: African Health Authors: Abdulsalam M. Yakasai Source Type: research

The association between serum vitamin D and body composition in South African HIV-infected women
Conclusion: Serum 25(OH)D was not associated with any BMD outcomes. Maintenance of lean mass could be important in preventing bone loss in this vulnerable group; however, longer follow-up may be necessary to confirm the association. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - September 30, 2021 Category: African Health Authors: Samuel Mwango Source Type: research

Southern African HIV Clinicians Society gender-affirming healthcare guideline for South Africa
No abstract available. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - September 28, 2021 Category: African Health Authors: Anastacia Tomson Source Type: research

Looking back at paediatric HIV treatment in South Africa. My, how we have grown!
This article describes some of the trials and tribulations that we went through trying to make sure that our paediatric HIV patients not only survived but thrived. Clinicians treating paediatric patients today have it so much easier because of what our colleagues and their patients went through in those early days. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - September 16, 2021 Category: African Health Authors: Leon J. Levin Source Type: research

Impact of a delayed diagnosis of vulvar cancer and its association with HIV infection: A 4-year review at a tertiary hospital in KwaZulu-Natal, South Africa
Conclusion: Although the study was retrospective, we found that vulvar cancer was prevalent in younger patients with HIV infection. Higher CD4 counts were associated with early-stage disease. Early sampling of suspicious lesions can ensure early diagnosis of vulvar cancer and the initiation of therapeutic interventions, particularly in HIV-infected patients. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - September 8, 2021 Category: African Health Authors: Ramakhosana S. Hlapane Source Type: research

Optimised paediatric antiretroviral treatment to achieve the 95-95-95 goals
While the progress towards reaching the UNAIDS 95-95-95 targets in South African adults seems promising, the progress in the paediatric population is lagging far behind; only 79% percent of children living with HIV know their status. Of these, only 47% are on treatment, and a mere 34% of those are virally suppressed. Thus, virological suppression has been attained in only 13% of children living with HIV in South Africa. Multiple factors contribute to the high treatment failure rate, one of them being a lack of paediatric-friendly antiretroviral treatment (ART) formulations. For example, the Lopinavir/ritonavir syrup, which...
Source: Southern African Journal of HIV Medicine - September 1, 2021 Category: African Health Authors: Mohandran Archary Source Type: research

Importance of global communication to combat global pandemics: Lessons from the HIV Online Provider Education programme
In many ways, the coronavirus disease 2019 (COVID-19) pandemic mirrors the challenges, lessons and opportunities of the HIV pandemic. In this article, we argue that global pandemics such as COVID-19 and HIV require a global response. We highlight the HIV Online Provider Education (HOPE) programme as an example of the importance of global communication when combating a pandemic. From both the COVID-19 and HIV pandemics, we have learned that to optimise health worldwide, it is necessary to have effective and efficient means of swiftly sharing experiences, expertise, best practices and guidelines. To prepare for the next publ...
Source: Southern African Journal of HIV Medicine - August 31, 2021 Category: African Health Authors: Efeose A. Airewele Source Type: research

Geographical variation in HIV testing in South Africa: Evidence from the 2017 national household HIV survey
Conclusion: The uptake of HIV testing across various districts in South Africa seems to be unequal. Intervention programmes must improve the overall uptake of HIV testing, especially in uMkhanyakude and Ugu in KwaZulu-Natal and Vhembe in Limpopo. Interventions must also focus on enhancing uptake of HIV testing amongst male participants in most districts. Strategies that would improve the uptake of HIV testing include HIV self-testing and community HIV testing, specifically home-based testing. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - August 31, 2021 Category: African Health Authors: Sean Jooste Source Type: research

A case series of emtricitabine-induced pure red cell aplasia
Conclusion: This study provides strong circumstantial evidence that emtricitabine plays an important role in the pathogenesis of reversible PRCA. The mechanisms through which emtricitabine induces PRCA remain unclear and require further study. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - August 30, 2021 Category: African Health Authors: Nithendra Manickchund Source Type: research

Derangement of protein S and C4b-binding protein levels as acquired thrombophilia in HIV-infected adult Nigerians
Conclusion: HIV infection causes elevated levels of C4BP and diminishes the serum levels of free protein S. We infer that the risk of thrombosis (as measured by these biomarkers) decreases with the use of antiretroviral drugs. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - August 23, 2021 Category: African Health Authors: Fatai O. Bello Source Type: research

Predictors of impaired pulmonary function in people living with HIV in an urban African setting
Conclusion: Our data show that a history of TB or pneumonia predicts impaired lung function. In order to improve timely access to spirometry, clinicians should be alert to the possibility of impaired lung function in people with a history of TB or pneumonia. (Source: Southern African Journal of HIV Medicine)
Source: Southern African Journal of HIV Medicine - August 17, 2021 Category: African Health Authors: Sarah E. van Riel Source Type: research

Establishing targets for advanced HIV disease: A call to action
The World Health Organization (WHO) has published a guideline for the management of individuals with advanced HIV disease (AHD) to reduce HIV-related deaths. The guideline consists of a package of recommendations including interventions to prevent, diagnose and treat common opportunistic infections, including tuberculosis (TB), cryptococcosis and severe bacterial infections, along with rapid initiation of antiretroviral treatment and enhanced adherence support. Currently no clear targets exist for these key interventions. Emerging programmatic data from Uganda, Tanzania and Nigeria suggest that an estimated 80% of eligible...
Source: Southern African Journal of HIV Medicine - August 10, 2021 Category: African Health Authors: David B. Meya Source Type: research