Editorial Board
(Source: Seminars in Nephrology)
Source: Seminars in Nephrology - March 1, 2021 Category: Urology & Nephrology Source Type: research
Table of Contents
(Source: Seminars in Nephrology)
Source: Seminars in Nephrology - March 1, 2021 Category: Urology & Nephrology Source Type: research
Pharmacologic Considerations for Opioid Use in Kidney Disease
Summary: Individuals with kidney disease have a high prevalence of chronic noncancer pain. Although opioids are not a recommended treatment option for chronic noncancer pain in the general population, a higher percentage of individuals with kidney disease receive opioid prescriptions for chronic pain. Individuals with kidney disease have an increased risk for opioid adverse events because of changes related to kidney disease progression, normative aging, and the pharmacology of opioid medications. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Authors: Chelsea E. Hawley, Erin Hickey, Laura K. Triantafylidis Source Type: research
Opioids and Acute Kidney Injury
Summary: Opioid use and misuse in the United States has been at epidemic proportions and is predicted to increase further in the setting of the Coronavirus disease 19 pandemic. Acute kidney injury is a condition associated with significant morbidity and increased mortality. We review the literature on the effect of opioids on kidney function and critically examine the association between opioid use and acute kidney injury and identify at-risk populations in whom opioids should be used with caution. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Authors: Mary Mallappallil, Siddhartha Bajracharya, Moro Salifu, Ernie Yap Source Type: research
Opioids in Hemodialysis Patients
Summary: Chronic pain and prescription opioid use are prevalent among patients with end-stage kidney disease treated with hemodialysis. Vulnerabilities to complications from opioid use are high in this patient population, as shown in many recent, well-conducted, patient-oriented studies. Such studies have highlighted the need for a balanced approach to pain management in hemodialysis patients that includes careful assessment of the risks and benefits of opioid prescriptions in this population. In this article, we review the available literature and experience regarding opioid prescriptions among hemodialysis patients, disc...
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Authors: Sahir Kalim, Karen S. Lyons, Sagar U. Nigwekar Source Type: research
Opioid Use in the Nondialysis Chronic Kidney Disease Population
Summary: Although pain is a common and burdensome condition in patients with chronic kidney disease (CKD), little is known about the use and safety of opioids in this patient population. Recommendations regarding opioid use in patients with CKD are based on pharmacokinetic data, extrapolation from non-CKD studies, and from clinical experience. Given the potential increased risk for opioid-related adverse events in patients with reduced kidney function, health care providers may be hesitant to prescribe opioids, resulting in inadequate pain control. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Authors: Min Zhuo, Laura K. Triantafylidis, Jiahua Li, Julie M. Paik Source Type: research
Opioids and Kidney Transplantation
Summary: The United States has faced an unprecedented opioid crisis in recent years, which has led to an increase in opioid overdose-related deaths and, consequently, an increase in the number of potential deceased donors available for transplantation. This new pool of potential organ donors is composed of younger donors with higher infectious disease transmission risk. The use of organs from these donors requires appropriate patient education, informed consent, and post-transplant monitoring practices. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Authors: Marie-Camille Lafargue, Yasar Caliskan, Krista L. Lentine, Leonardo V. Riella Source Type: research
Nonopioid Approaches to Pain Management in Chronic Kidney Disease
Summary: Patients with chronic kidney disease (CKD) and end-stage renal disease experience high pain and symptom burden, but management of chronic pain in this population remains challenging. Recent studies have shown a high rate of opioid prescription and use in patients with kidney disease. However, the concern for opioid-related morbidity and mortality suggests a need to reconsider the safety and efficacy of opioid use in patients with CKD. In this review, we describe the current approaches to pain management in CKD, highlight the evolving opioid-related risks and kidney-specific concerns, and offer both pharmacologic a...
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Authors: Emily Lu, Holly M. Koncicki Source Type: research
Nonpharmacologic Treatments for Opioid Reduction in Patients With Advanced Chronic Kidney Disease
Summary: Opioid analgesics carry risk for serious health-related harms in patients with advanced chronic kidney disease (CKD) and end-stage kidney disease. In the general population with chronic noncancer pain, there is some evidence that opioid reduction or discontinuation is associated with improved pain outcomes; however, tapering opioids abruptly or without providing supportive interventions can lead to physical and psychological harms and relapse of opioid use. There is emerging evidence that nonpharmacologic treatments such as psychosocial interventions, acupuncture, and interdisciplinary pain management programs are...
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Authors: Carrie E. Brintz, Martin D. Cheatle, Laura M. Dember, Alicia A. Heapy, Manisha Jhamb, Amanda J. Shallcross, Jennifer L. Steel, Paul L. Kimmel, Daniel Cukor, HOPE Consortium Source Type: research
Introduction: Opioids and the Kidney
The opioid epidemic that has swept dramatically across the United States has affected numerous patient populations, and patients with kidney disease unfortunately are no exception. Pain is an all-too-common symptom among patients with kidney disease, adding to their disease burden, but often is under-recognized and treated inadequately. The nephrology community has become increasingly aware of the impact of opioid use on the kidneys and patients with kidney disease, but our understanding is still in the nascent stages and much remains unknown. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Authors: Julie M. Paik Source Type: research
Opioids and Kidney Stones
Summary: In recent years, the use of opioids in medical practice has come under significant scrutiny. This, in part, is owing to evidence of overprescription and overuse of opioid medications, as well as the unintended consequences and side effects for patients who take these medications. Here, we review the role of opioids and the responsible use of these medications with respect to kidney stone disease and surgical interventions for kidney stones. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Authors: Christina Kottooran, Kevan Sternberg, Karen L. Stern, Vernon M. Pais, Brian H. Eisner Source Type: research
Masthead
(Source: Seminars in Nephrology)
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Source Type: research
Editorial Board
(Source: Seminars in Nephrology)
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Source Type: research
Table of Contents
(Source: Seminars in Nephrology)
Source: Seminars in Nephrology - January 1, 2021 Category: Urology & Nephrology Source Type: research
Pathophysiology of Gout
Multiple interacting checkpoints are involved in the pathophysiology of gout. Hyperuricemia is the key risk factor for gout and is considered a prerequisite for monosodium urate (MSU) crystal formation. Urate underexcretion through renal and gut mechanisms is the major mechanism for hyperuricemia in most people. Multiple genetic, environmental, and metabolic factors are associated with serum urate and alter urate transport or synthesis. Urate supersaturation is the most important factor for MSU crystal formation, and other factors such as temperature, pH, and connective tissue components also play a role. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - November 1, 2020 Category: Urology & Nephrology Authors: Ravi K. Narang, Nicola Dalbeth Source Type: research
