Editorial Board
(Source: Seminars in Nephrology)
Source: Seminars in Nephrology - July 1, 2023 Category: Urology & Nephrology Source Type: research
Table of Contents
(Source: Seminars in Nephrology)
Source: Seminars in Nephrology - July 1, 2023 Category: Urology & Nephrology Source Type: research
Updates in Plasma Cell Dyscrasias and Related Monoclonal Immunoglobulin-Mediated Renal Disease
Pathogenic roles of monoclonal immunoglobulins in kidney disease have been attributed previously to malignant plasma cell and lymphoproliferative disorders such as multiple myeloma, lymphoplasmacytic lymphoma, chronic lymphocytic leukemia, or amyloid light chain amyloidosis. Improved technology, advancements in molecular diagnostics, and highly sensitive imaging techniques have established the need to redefine monoclonal gammopathies and the kidney disorders that are associated with monoclonal immunoglobulins regardless of tumor burden. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - May 29, 2023 Category: Urology & Nephrology Authors: Shonali Midha, Omar Nadeem, Umut Selamet Source Type: research
Transplant Onconephrology: An Update
Transplant onconephrology is a growing specialty focused on the health care of kidney transplant recipients with cancer. Given the complexities associated with the care of transplant patients, along with the advent of novel cancer therapies such as immune checkpoint inhibitors and chimeric antigen –receptor T cells, there is a dire need for the subspecialty of transplant onconephrology. The management of cancer in the setting of kidney transplantation is best accomplished by a multidisciplinary team, including transplant nephrologists, oncologists, and patients. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - May 18, 2023 Category: Urology & Nephrology Authors: Christopher D. Blosser, Andrew J. Portuguese, Cecilia Santana, Naoka Murakami Source Type: research
Onconephrology and Thrombotic Microangiopathy: Looking Beyond the Horizon
Thrombotic microangiopathies (TMAs) represent a complex interaction of endothelial and podocyte biology, nephron physiology, complement genetics, and oncologic therapies with host immunology. The complexity of various factors, such as molecular causes, genetic expressions, and immune system mimicking, along with incomplete penetrance, make it difficult to find a straightforward solution. As a result, there may be variations in diagnosis, study, and treatment approaches, and achieving a consensus can be challenging. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - May 15, 2023 Category: Urology & Nephrology Authors: Prakash Gudsoorkar, Ala Abudayyeh, Amanda Tchakarov, Ramy Hanna Source Type: research
Cisplatin Nephrotoxicity: Novel Insights Into Mechanisms and Preventative Strategies
Cisplatin is a highly effective chemotherapeutic agent that has been used for more than 50 years for a variety of cancers; however, its use is limited by toxicity, including nephrotoxicity. In this in-depth review, we discuss the incidence of cisplatin-associated acute kidney injury, as well as common risk factors for its development. Cisplatin accumulates in the kidney tubules and causes AKI through various mechanisms, including DNA damage, oxidative stress, and apoptosis. We also discuss the spectrum of nephrotoxicity, including acute and chronic impairment of kidney function, electrolyte disturbances, and thrombotic mic...
Source: Seminars in Nephrology - May 12, 2023 Category: Urology & Nephrology Authors: Shveta S. Motwani, Sharneet Sandhu Kaur, Abhijat Kitchlu Source Type: research
Genitourinary Cancer: Updates on Treatments and Their Impact on the Kidney
Genitourinary cancers are diverse in their presentation, prevalence, and mortality risk. Although there have been significant advancements in medical (eg, immune checkpoint inhibitors and tyrosine kinase inhibitors) and surgical treatments of genitourinary cancers, patients are still at risk for chronic kidney disease, hypertension, and electrolyte derangements in the short and long term. In addition, pre-existing kidney disease may increase the risk of developing some genitourinary cancers. This review focuses on the kidney-related effects of treatments for renal cell carcinoma and bladder and prostate cancers. (Source: S...
Source: Seminars in Nephrology - May 10, 2023 Category: Urology & Nephrology Authors: Paloma Orozco Scott, Priya Deshpande, Matthew Abramson Source Type: research
Rescue Therapies for AKI in Onconephrology: Rasburicase and Glucarpidase
Tumor lysis syndrome (TLS) and high-dose methotrexate (HD MTX) toxicity can present with potentially severe complications, including acute kidney injury, in patients with malignancy. Guidelines for using rasburicase and glucarpidase as rescue therapies for TLS and HD MTX toxicity, respectively, are widely used by clinicians intending to mitigate organ toxicity and decrease morbidity and mortality as a consequence of cancer therapy. This review discusses the pathogenesis of TLS and HD MTX –associated toxicity, to understand the mechanism of action of these therapeutic agents and to review the currently available evidence ...
Source: Seminars in Nephrology - May 9, 2023 Category: Urology & Nephrology Authors: Sheron Latcha, Chintan V. Shah Source Type: research
Amyloidosis and the Kidney: An Update
Various types of systemic amyloidosis can wreak havoc on the architecture and functioning of the kidneys. Amyloidosis should be suspected in patients with worsening kidney function, proteinuria, and multisystem involvement, but isolated kidney involvement also is possible. Confirming the amyloidosis type and specific organ dysfunction is of paramount importance to select the appropriately tailored treatment and aim for better survival while avoiding treatment-associated toxicities. Amyloid renal staging in light chain amyloidosis amyloidosis helps inform prognosis and risk for end-stage kidney disease. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - May 4, 2023 Category: Urology & Nephrology Authors: Ralph Nader, Avital Angel-Korman, Andrea Havasi Source Type: research
Masthead
(Source: Seminars in Nephrology)
Source: Seminars in Nephrology - May 1, 2023 Category: Urology & Nephrology Source Type: research
Editorial Board
(Source: Seminars in Nephrology)
Source: Seminars in Nephrology - May 1, 2023 Category: Urology & Nephrology Source Type: research
Table of Contents
(Source: Seminars in Nephrology)
Source: Seminars in Nephrology - May 1, 2023 Category: Urology & Nephrology Source Type: research
Immune Checkpoint Inhibitor –Associated AKI: Debates in Diagnosis, Management, and Rechallenge
Immune checkpoint inhibitors (ICIs) are now established treatments for advanced cancer and their use is now ubiquitous. The high upside of ICIs is tempered by their toxicity profile affecting almost every organ, including the kidneys. Although acute interstitial nephritis is the major kidney-related adverse effect of checkpoint inhibitors, other manifestations such as electrolyte abnormalities and renal tubular acidosis have been described. With increasing awareness and recognition of these events, the focus has shifted to non-invasive identification of ICI-acute interstitial nephritis, with sophisticated approaches involv...
Source: Seminars in Nephrology - May 1, 2023 Category: Urology & Nephrology Authors: Harish Seethapathy, Sandra M. Herrmann, Arash Rashidi Source Type: research
Advance Care Planning, Shared Decision Making, and Serious Illness Conversations in Onconephrology
Advance care planning, shared decision making, and serious illness conversations are communication processes designed to promote patient-centered care. In onconephrology, patients face a series of complex medical decisions regarding their care at the intersection of oncology and nephrology. Clinicians who aim to ensure that patient preferences and values are integrated into treatment planning must work within a similarly complex care team comprising multiple disciplines. In this review, we describe key decision points in a patient's care trajectory, as well as guidance on how and when to engage in advance care planning, sh...
Source: Seminars in Nephrology - April 28, 2023 Category: Urology & Nephrology Authors: Amanda Jane Reich, John Adam Reich, Paul Mathew Source Type: research
Introduction: Clinical Innovations in Onconephrology: What's New in 2023
Onconephrology is a rapidly growing subspecialty that focuses on the intersection of cancer and kidney-related disorders. Because patients with cancer are living longer and increasingly are exposed to life-saving yet sometimes nephrotoxic therapies, they are at higher risk for complications such as acute and chronic kidney injury, therapy-associated hypertension, and electrolyte abnormalities. Nephrologists now are tasked with managing these complex issues in an ever-changing and rapidly evolving landscape of cancer care. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - April 26, 2023 Category: Urology & Nephrology Authors: Shruti Gupta, Naoka Murakami Source Type: research
